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THINNES Cyrille

Main Referenced Co-authors
Schofield, Christopher J. (8)
Chowdhury, Rasheduzzaman (3)
Kawamura, Akane (3)
Tumber, Anthony (3)
Yeh, Tzu-Lan (3)
Main Referenced Keywords
Humans (6); Animals (3); Protein Binding (3); Female (2); Mice (2);
Main Referenced Disciplines
Chemistry (7)
Biochemistry, biophysics & molecular biology (4)
Human health sciences: Multidisciplinary, general & others (1)
Social & behavioral sciences, psychology: Multidisciplinary, general & others (1)

Publications (total 12)

The most cited

169 citations (Scopus®)

Yeh, T.-L., Leissing, T. M., Abboud, M. I., Thinnes, C., Atasoylu, O., Holt-Martyn, J. P., Zhang, D., Tumber, A., Lippl, K., Lohans, C. T., Leung, I. K. H., Morcrette, H., Clifton, I. J., Claridge, T. D. W., Kawamura, A., Flashman, E., Lu, X., Ratcliffe, P. J., Chowdhury, R., ... Schofield, C. J. (2017). Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical science, 8 (11), 7651-7668. doi:10.1039/c7sc02103h https://hdl.handle.net/10993/39145

Thinnes, C., Lohans, C. T., Abboud, M. I., Yeh, T.-L., Tumber, A., Nowak, R. P., Attwood, M., Cockman, M. E., Oppermann, U., Loenarz, C., & Schofield, C. J. (2019). Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding. Chemistry, 25 (8), 2019-2024. doi:10.1002/chem.201804790
Peer Reviewed verified by ORBi

Kiriakidis, S., Hoer, S. S., Burrows, N., Biddlecome, G., Khan, M. N., Thinnes, C., Schofield, C. J., Rogers, N., Botto, M., Paleolog, E., & Maxwell, P. H. (2017). Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor. Kidney International, 92 (4), 900-908. doi:10.1016/j.kint.2017.03.008
Peer Reviewed verified by ORBi

Kulkarni, A., Mateus, M., Thinnes, C., McCullagh, J. S., Schofield, C. J., Taylor, G. P., & Bangham, C. R. M. (2017). Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1. Cell chemical biology, 24 (11), 1377-1387.e3. doi:10.1016/j.chembiol.2017.08.016
Peer reviewed

Yeh, T.-L., Leissing, T. M., Abboud, M. I., Thinnes, C., Atasoylu, O., Holt-Martyn, J. P., Zhang, D., Tumber, A., Lippl, K., Lohans, C. T., Leung, I. K. H., Morcrette, H., Clifton, I. J., Claridge, T. D. W., Kawamura, A., Flashman, E., Lu, X., Ratcliffe, P. J., Chowdhury, R., ... Schofield, C. J. (2017). Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical science, 8 (11), 7651-7668. doi:10.1039/c7sc02103h
Peer reviewed

Karuppagounder, S. S., Alim, I., Khim, S. J., Bourassa, M. W., Sleiman, S. F., John, R., Thinnes, C., Yeh, T.-L., Demetriades, M., Neitemeier, S., Cruz, D., Gazaryan, I., Killilea, D. W., Morgenstern, L., Xi, G., Keep, R. F., Schallert, T., Tappero, R. V., Zhong, J., ... Ratan, R. R. (2016). Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine, 8 (328), 328ra29. doi:10.1126/scitranslmed.aac6008
Peer Reviewed verified by ORBi

Thinnes, C., Tumber, A., Yapp, C., Scozzafava, G., Yeh, T., Chan, M. C., Tran, T. A., Hsu, K., Tarhonskaya, H., Walport, L. J., Wilkins, S. E., Martinez, E. D., Muller, S., Pugh, C. W., Ratcliffe, P. J., Brennan, P. E., Kawamura, A., & Schofield, C. J. (2015). Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Chemical Communications, 51 (84), 15458-61. doi:10.1039/c5cc06095h
Peer Reviewed verified by ORBi

Horita, S., Scotti, J. S., Thinnes, C., Mottaghi-Taromsari, Y. S., Thalhammer, A., Ge, W., Aik, W., Loenarz, C., Schofield, C. J., & McDonough, M. A. (2015). Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure, 23 (4), 639-52. doi:10.1016/j.str.2015.01.014
Peer Reviewed verified by ORBi

Thinnes, C., England, K. S., Kawamura, A., Chowdhury, R., Schofield, C. J., & Hopkinson, R. J. (2014). Targeting histone lysine demethylases - progress, challenges, and the future. Biochimica et biophysica acta, 1839 (12), 1416-32. doi:10.1016/j.bbagrm.2014.05.009
Peer reviewed

Egleton, J. E., Thinnes, C., Seden, P. T., Laurieri, N., Lee, S. P., Hadavizadeh, K. S., Measures, A. R., Jones, A. M., Thompson, S., Varney, A., Wynne, G. M., Ryan, A., Sim, E., & Russell, A. J. (2014). Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1. Bioorganic & Medicinal Chemistry, 22 (11), 3030-54. doi:10.1016/j.bmc.2014.03.015
Peer reviewed

Laurieri, N., Egleton, J. E., Varney, A., Thinnes, C., Quevedo, C. E., Seden, P. T., Thompson, S., Rodrigues-Lima, F., Dairou, J., Dupret, J.-M., Russell, A. J., & Sim, E. (2013). A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1. PLoS ONE, 8 (8), 70600. doi:10.1371/journal.pone.0070600
Peer Reviewed verified by ORBi

Hopkinson, R. J., Tumber, A., Yapp, C., Chowdhury, R., Aik, W., Che, K. H., Li, X. S., Kristensen, J. B. L., King, O. N. F., Chan, M. C., Yeoh, K. K., Choi, H., Walport, L. J., Thinnes, C., Bush, J. T., Lejeune, C., Rydzik, A. M., Rose, N. R., Bagg, E. A., ... Kawamura, A. (2013). 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science, 4 (8), 3110-3117. doi:10.1039/C3SC51122G
Peer reviewed

Badia, K., & Thinnes, C. (2009). Altersgemischte oder altersgleiche Gruppe: eine Befragung von Erziehern einer Maison Relais. In Ministère de la Famille et de l'Intégration, Entente des Foyers de Jour, Syndicat des Villes et Communes luxembourgeoises, ... Université du Luxembourg (Eds.), Maison Relais pour Enfants - Le manuel - Das Handbuch (pp. 251-253). Éditions le Phare.

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