Reference : Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Pa...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/10993/32462
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
English
Wang, Lisa [> >]
Heckman, Michael G. [> >]
Aasly, Jan O. [> >]
Annesi, Grazia [> >]
Bozi, Maria [> >]
Chung, Sun Ju [> >]
Clarke, Carl [> >]
Crosiers, David [> >]
Eckstein, Gertrud [> >]
Garraux, Gaetan [> >]
Hadjigeorgiou, Georgios M. [> >]
Hattori, Nobu [> >]
Jeon, Beom [> >]
Kim, Yun J. [> >]
Kubo, Masato [> >]
Lesage, Suzanne [> >]
Lin, Juei Jueng [> >]
Lynch, Timothy [> >]
Lichtner, Peter [> >]
Mellick, George D. [> >]
Mok, Vincent [> >]
Morrison, Karin E. [> >]
Quattrone, Aldo [> >]
Satake, Wataru [> >]
Silburn, Peter A. [> >]
Stefanis, Leonidas [> >]
Stockton, Joanne D. [> >]
Tan, Eng King [> >]
Toda, Tatsushi [> >]
Brice, Alexis [> >]
Van Broeckhoven, Christine [> >]
Uitti, Ryan J. [> >]
Wirdefeldt, Karin [> >]
Wszolek, Zbigniew [> >]
Xiromerisiou, Georgia [> >]
Maraganore, Demetrius M. [> >]
Gasser, Thomas [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Farrer, Matthew J. [> >]
Ross, Owen A. [> >]
Sharma, Manu [> >]
Jan-2017
Neurobiology of aging
49
217.e1-217.e4
Yes (verified by ORBilu)
International
0197-4580
1558-1497
United States
[en] Genetic epidemiology ; LRRK2 ; PARK16 ; Parkinson's disease
[en] A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
http://hdl.handle.net/10993/32462
Copyright (c) 2016 Elsevier Inc. All rights reserved.

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