| Reference : Identification of a Leu-lle internalization motif within the cytoplasmic domain of th... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/6257 | |||
| Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor | |
| English | |
| Thiel, S. [> >] | |
Behrmann, Iris  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Timmermann, A. [> >] | |
| Dahmen, H. [> >] | |
| Müller-Newen, G. [> >] | |
| Schaper, F. [> >] | |
| Tavernier, J. [> >] | |
| Pitard, V. [> >] | |
| Heinrich, P. C. [> >] | |
| Graeve, L. [> >] | |
| 1999 | |
| Biochemical Journal | |
| Portland Press | |
| 339 (Pt 1) | |
| 15-9 | |
| Yes (verified by ORBilu) | |
| International | |
| 0264-6021 | |
| 1470-8728 | |
| London | |
| United Kingdom | |
| [en] Animals ; Isoleucine ; Kinetics ; Leucine ; Leukemia Inhibitory Factor ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Lymphokines ; Membrane Glycoproteins ; Microscopy, Fluorescence ; Receptors, Cytokine ; Interleukin-6 ; Humans ; Growth Inhibitors ; Antigens, CD ; Base Sequence ; COS Cells ; Cell Line ; Cytokine Receptor gp130 ; Cytoplasm ; DNA Primers ; Endocytosis ; Flow Cytometry ; Receptors, OSM-LIF | |
| [en] Leukaemia inhibitory factor (LIF) signals via a heterodimeric receptor complex comprised of the LIF receptor (LIFR) and the interleukin (IL)-6 signal transducer gp130. Upon binding to its cognate receptor LIF is internalized. In this study, we show that the LIFR is endocytosed independently of gp130. By using a heterochimaeric receptor system we identified a dileucine-based internalization motif within the cytoplasmic domain of the LIFR. Our findings suggest that a heterodimeric LIFR/gp130 complex and homodimeric gp130/gp130 complex are endocytosed via distinct internalization signals. | |
| http://hdl.handle.net/10993/6257 |
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