| Reference : G protein activation: a receptor-independent mode of action for cationic amphiphilic ... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/5737 | |||
| G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides | |
| English | |
| Mousli, M. [> >] | |
Bueb, Jean-Luc  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Bronner, C. [> >] | |
| Rouot, B. [> >] | |
| Landry, Y. [> >] | |
| 1990 | |
| Trends in Pharmacological Sciences | |
| Elsevier | |
| 11 | |
| 9 | |
| 358-62 | |
| Yes (verified by ORBilu) | |
| 0165-6147 | |
| 1873-3735 | |
| Cambridge | |
| United Kingdom | |
| [en] pharmacology ; Animals ; Biotransformation ; GTP-Binding Proteins ; Humans ; Molecular Sequence Data ; Neuropeptides ; Peptides ; Wasp Venoms ; metabolism ; chemistry ; Amino Acid Sequence | |
| [en] The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these effects are inhibited by pertussis toxin and involve a transient increase in IP3, no selective membrane receptors have been identified. However, it has recently been shown that these compounds activate G proteins in vitro. Here Yves Landry and colleagues discuss the proposal that direct activation of G protein is the physiological mechanism of action of substance P on rat peritoneal mast cells, this mechanism being mimicked by mastoparan and 48/80, and possibly by other cationic amphiphilic peptides such as kinins. These compounds might be of help in defining the interaction between membrane receptors and G proteins. | |
| http://hdl.handle.net/10993/5737 |
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