| Reference : Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/5718 | |||
| Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells | |
| English | |
| Valentin, F. [> >] | |
Bueb, Jean-Luc  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Kieffer, P. [> >] | |
| Tschirhart, Eric [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Atkinson, J. [> >] | |
| 2005 | |
| Fundamental and Clinical Pharmacology | |
| Blackwell Science | |
| 19 | |
| 6 | |
| 661-7 | |
| Yes (verified by ORBilu) | |
| 0767-3981 | |
| 1472-8206 | |
| Oxford | |
| United Kingdom | |
| [en] enzymology ; Electrophoresis, Polyacrylamide Gel ; Enzyme Activation ; Enzyme Induction ; Enzyme-Linked Immunosorbent Assay ; Humans ; Matrix Metalloproteinase 2 ; Myocardium ; Oxidative Stress ; biosynthesis ; metabolism ; Cells, Cultured | |
| [en] Oxidative stress is a cardinal feature of the inflammatory process and is involved in various pathologies including atherosclerosis. One of the important mechanisms in which oxidative stress may play a role is activation of matrix metalloproteinases such as MMP-2, which are involved in plaque destabilization. We investigated the mechanisms by which oxidative stress induces MMP-2 activation in cultured human coronary artery smooth muscle cells. Using zymography and Western blot analysis, we showed that oxidized low-density lipoproteins activate MMP-2 through up-regulation of the expression and activation of a membrane-type 1 matrix metalloproteinase (MT1-MMP). A second mechanism of MMP-2 activation involves oxidative radicals generated by the xanthine/xanthine oxidase complex (X/Xo). Research on these two mechanisms of MMP activation could lead to the elaboration of new vascular therapies for the treatment of atheroma based on interruption of a specific oxidative stress pathway. | |
| http://hdl.handle.net/10993/5718 | |
| 10.1111/j.1472-8206.2005.00371.x |
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