Reference : RESTING STATE FUNCTIONAL CONNECTIVITY MARKERS FOR THE EFFICACY OF COGNITVE PAIN MODUL...

	Document type :	Scientific congresses, symposiums and conference proceedings : Unpublished conference
	Discipline(s) :	Social & behavioral sciences, psychology : Animal psychology, ethology & psychobiology Social & behavioral sciences, psychology : Neurosciences & behavior Social & behavioral sciences, psychology : Treatment & clinical psychology
	To cite this reference:	http://hdl.handle.net/10993/55338

Title :	RESTING STATE FUNCTIONAL CONNECTIVITY MARKERS FOR THE EFFICACY OF COGNITVE PAIN MODULATION IN AGING
Language :	English
Translated title :	[en] RESTING STATE FUNCTIONAL CONNECTIVITY MARKERS FOR THE EFFICACY OF COGNITVE PAIN MODULATION IN AGING
Author, co-author :	van der Meulen, Marian [University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) >]
	Rischer, Katharina [University of Luxembourg, Luxembourg > Department of Behavioural and Cognitive Sciences]
	Dierolf, Angelika [University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) >]
	Gonzalez-Roldan, Ana Maria [University of the Balearic Islands, Spain > Cognitive and Affective Neuroscience and Clinical Psychology, Research Institute of Health Sciences,]
	Montoya, Pedro [University of the Balearic Islands, Spain > Cognitive and Affective Neuroscience and Clinical Psychology, Research Institute of Health Sciences,]
	Anton, Fernand [University of Luxembourg > > >]
Publication date :	29-Mar-2023
Peer reviewed :	Yes
On invitation :	No
Audience :	International
Event name :	65th TeaP, the annual meeting of the General Psychology section of the German Psychological Society (DGPs)
Event date :	26 - 29 March, 2023
Event organizer :	University of Trier, Leibniz Institute for Psychology (ZPID) and the Department of General Psychology at the Trier University
Event place (city) :	Trier
Event country :	Germany
Keywords :	[en] pain ; cognitive pain modulation ; aging ; functional connectivity ; resting state fMRI
Abstract :	[en] A growing number of studies suggest that aging is associated with a decrease in efficacy of cognitive pain modulation. Resting state functional connectivity (rsFC) analysis of the brain offers one way of investigating the potential neural mechanisms that may underly this age-related decline. In this study, 32 young (26.7 ± 4.3 years) and 32 healthy older (68.3 ± 7.1 years) adults underwent a 6-minute resting state fMRI scan, as well as a pain distraction paradigm. In the latter, participants received painful heat stimuli while performing either an easy or a difficult working memory task. We performed region-of-interest (ROI) to ROI rsFC analysis of the imaging data, focusing on regions implicated in pain processing and descending pain control. We then examined the relationship between rsFC parameters and the magnitude of the distraction effect (the reduction in perceived pain intensity during the difficult vs the easy task). Older adults showed reduced connectivity compared to young adults between several descending pain modulatory regions, including the ACC and PAG, the right secondary somatosensory cortex (SII) and right dorsolateral prefrontal cortex and between the ACC and left amygdala. Importantly, rsFC in older adults correlated positively with the distraction effect, between several regions including the right SI and right amygdala, the left SI and right insula and between the ACC and left amygdala. Our findings thus demonstrate, for the first time, that reduced cognitive pain modulation in older age is directly associated with decreased rsFC within key nodes of the descending pain control network.
Funders :	Fonds National de la Recherche - FnR
Name of the research project :	Age-related Changes In Human Pain Perception And Modulation: Evidence From Functional Brain Imaging
Target :	Researchers
Permalink :	http://hdl.handle.net/10993/55338
FnR project :	FnR ; FNR11266318 > Marian Van Der Meulen > ACHE > Age-related Changes In Human Pain Perception And Modulation: Evidence From Functional Brain Imaging > 01/09/2017 > 28/02/2021 > 2016

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	Fulltext file(s): File Commentary Version Size Access Open access Abstract_TeaP2023_MvdM.pdf Publisher postprint 418.82 kB View/Open Additional material(s): File Commentary Size Access Open access Program_TeaP_2023.pdf 3.16 MB View/Open

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