Reference : Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-r...

	Document type :	E-prints/Working papers : Already available on another site
	Discipline(s) :	Life sciences : Genetics & genetic processes Human health sciences : Immunology & infectious disease Human health sciences : Neurology
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/51989

Title :	Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile
Language :	English
Author, co-author :	Capelle, Christophe [> >]
	Cire, Séverine [> >]
	Hansen, Maxime [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
	Pavelka, Lukas [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
	Hedin, Fanny [> >]
	Konstantinou, Maria [> >]
	Revets, Dominique [> >]
	Tslaf, Vera [University of Luxembourg > >]
	Marques, Taina [> >]
	Baron, Alexandre [> >]
	Domingues, Olivia [> >]
	Zeng, Ni [> >]
	May, Patrick [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
	Cosma, Antonio [University of Luxembourg > >]
	Balling, Rudi [> >]
	Krüger, Rejko [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
	Ollert, Markus [University of Luxembourg > >]
	He, Feng [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Publication date :	22-Jul-2022
Peer reviewed :	No
Abstract :	[en] Parkinson’s disease (PD) is the second most common neurodegenerative disease. Brain neuroinflammation plays a role in PD pathogenesis. However, the involvement of the peripheral immune system has not been systematically investigated. Here we analyzed >700 combinatorial immunological features in fresh blood of 28 early-to-mid-stage PD patients and 24 matched controls. We found an enhanced cytotoxic immune profile in idiopathic PD patients (iPD), with a higher frequency of terminally-differentiated effector CD8 T (TEMRA), late-differentiated CD8+ natural killer T cells and neutrophils. This immune profile was intensified by elevated serum granzyme A, reduced percentages of CD8+FOXP3+ regulatory T cells and group 2 innate lymphoid cells with immunosuppressive or tolerance-inducing functions. The frequency of CD8 TEMRA was negatively correlated with disease duration, suggesting a contribution to PD pathogenesis. Our work provides a comprehensive map on disturbed peripheral adaptive and innate immune cells in early-to-mid iPD, proposing easily-accessible candidates for early diagnosis and treatments.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; Luxembourg Institute of Health - LIH
Funders :	Fonds National de la Recherche - FnR ; Luxembourg Personalized Medicine Consortium (PMC)
Target :	Researchers
Permalink :	http://hdl.handle.net/10993/51989
DOI :	10.21203/rs.3.rs-1834770/v1
Other URL :	https://www.researchsquare.com/article/rs-1834770/v1
source URL :	https://www.researchsquare.com/article/rs-1834770/v1
FnR project :	FnR ; FNR11264123 > Rejko Krüger > NCER-PD > Ncer-pd > 01/01/2015 > 30/11/2020 > 2015

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