Reference : NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/50956

Title :	NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells
Language :	English
Author, co-author :	Grandbarbe, Luc [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Michelucci, Alessandro [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > >]
	Heuschling, Paul [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Pavlou, Maria Angeliki [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Ginolhac, Aurélien [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Publication date :	8-Apr-2021
Journal title :	Cells
Publisher :	Multidisciplinary Digital Publishing Institute (MDPI)
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
e-ISSN :	2073-4409
City :	Basel
Country :	Switzerland
Keywords :	[en] NF-κB ; apoptosis ; astrocyte ; differentiation ; neural progenitor cell ; tumor necrosis factor
Abstract :	[en] The NF-κB signaling pathway is crucial during development and inflammatory processes. We have previously shown that NF-κB activation induces dedifferentiation of astrocytes into neural progenitor cells (NPCs). Here, we provide evidence  that the NF-κB pathway plays also a fundamental role during the differentiation of NPCs into astrocytes. First, we show that the NF-κB pathway is essential to initiate astrocytic differentiation as its early inhibition induces NPC apoptosis and impedes their differentiation. Second, we demonstrate that persistent NF-κB activation affects NPC-derived astrocyte differentiation. Tumor necrosis factor (TNF)-treated NPCs show NF-κB activation, maintain their multipotential and proliferation properties, display persistent expression of immature markers and inhibit astrocyte markers. Third, we analyze the effect of  NF-κB activation on the main known astrocytic differentiation pathways, such as NOTCH and JAK-STAT. Our findings suggest that the NF-κB pathway plays a dual fundamental role during NPC differentiation into astrocytes: it promotes astrocyte specification, but its persistent activation impedes their differentiation.
Research centres :	University of Luxembourg:DLSM
Target :	Researchers
Permalink :	http://hdl.handle.net/10993/50956

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