Development of data integration tools within functional genomics

Teixeira Queiros, Pedro

Reference : Development of data integration tools within functional genomics


	Document type :	Dissertations and theses : Doctoral thesis
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	Focus Areas :	Systems Biomedicine; Computational Sciences
	To cite this reference:	http://hdl.handle.net/10993/50775

Title :	Development of data integration tools within functional genomics
Language :	English
Author, co-author :	Teixeira Queiros, Pedro [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology >]
Publication date :	22-Mar-2022
Institution :	University of Luxembourg, Luxembourg
Name of the degree :	PhD in Biology
Number of pages :	147
Supervisor :	May, Patrick
	Wilmes, Paul
President of the jury :	Schymanski, Emma
Member of the jury :	Finn, Rob
	Rattei, Thomas
Keywords :	[en] bioinformatics ; protein function annotation ; data integration
Abstract :	[en] Due to technological advances across all scientific domains, data is generated at an extremely fast pace. This is especially true in biology, where advances in computational and sequencing technologies led to the necessity to develop automated methods for data analysis; thus the field of bioinformatics was born. This thesis focuses on one specific field within bioinformatics - functional genomics. To be precise, in the development of techniques and software for the integration of data to generate novel insights. Indeed, as the amount of knowledge increases, so does the need to integrate it systematically. In this context, the work described herein relates to the integration of multiple resources to improve the functional annotation of proteins, which led to the development of two bioinformatic tools - Mantis and UniFunc. For the downstream integration and analysis of functional predictions, a network annotation tool was developed - UniFuncNet, which, together with the previous tools, enables the efficient functional characterisation of individual organisms or communities.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group)
Funders :	Luxembourg National Research Fund ; European Research Council
Target :	Researchers ; Students ; General public
Permalink :	http://hdl.handle.net/10993/50775

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