| Reference : Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential ... |
| E-prints/Working papers : Already available on another site | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| Computational Sciences | |||
| http://hdl.handle.net/10993/49323 | |||
| Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19 | |
| English | |
| Islam, Saba [La Trobe University] | |
| Charnley, Mirren [Swinburne University of Technology] | |
| Bindra, Guneet [La Trobe University] | |
| Ratcliffe, Julian [La Trobe University] | |
| Zhou, Jiangtao [ETH Zurich] | |
| Mezzenga, Raffaele [ETH Zurich] | |
| Hulett, Mark [La Trobe University] | |
Han, Kyunghoon  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit] | |
| Berryman, Josh [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >] | |
| Reynolds, Nicholas [La Trobe University] | |
| 24-Nov-2021 | |
| 1 | |
| BioRxiv | |
| 13 | |
| No | |
| [en] Coronavirus ; amyloid ; self assembly | |
| [en] COVID-19 is primarily known as a respiratory disease caused by the virus SARS-CoV-2. However, neurological symptoms such as memory loss, sensory confusion, cognitive and psychiatric issues, severe headaches, and even stroke are reported in as many as 30% of cases and can persist even after the infection is over (so-called ‘long COVID’). These neurological symptoms are thought to be caused by brain inflammation, triggered by the virus infecting the central nervous system of COVID-19 patients, however we still don’t fully understand the mechanisms for these symptoms. The neurological effects of COVID-19 share many similarities to neurodegenerative diseases such as Alzheimer’s and Parkinson’s in which the presence of cytotoxic protein-based amyloid aggregates is a common etiological feature. Following the hypothesis that some neurological symptoms of COVID-19 may also follow an amyloid etiology we performed a bioinformatic scan of the SARS-CoV-2 proteome, detecting peptide fragments that were predicted to be highly amyloidogenic. We selected two of these peptides and discovered that they do rapidly self-assemble into amyloid. Furthermore, these amyloid assemblies were shown to be highly toxic to a neuronal cell line. We introduce and support the idea that cytotoxic amyloid aggregates of SARS-CoV-2 proteins are causing some of the neurological symptoms commonly found in COVID-19 and contributing to long COVID, especially those symptoms which are novel to long COVID in contrast to other post-viral syndromes. | |
| University of Luxembourg: High Performance Computing - ULHPC | |
| Fonds National de la Recherche - FnR | |
| QUIRE | |
| Researchers ; Professionals | |
| http://hdl.handle.net/10993/49323 | |
| 10.1101/2021.11.24.469537 | |
| This preprint has no relevance to any molecular species present in or generated by any current vaccine. | |
| https://www.biorxiv.org/content/10.1101/2021.11.24.469537v1 | |
| FnR ; FNR14588607 > Joshua T Berryman > QUIRE > Quantum Infra Red Efficiently > 01/03/2021 > > 2020 |
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