| Reference : Cross-sectional focusing of red blood cells in a constricted microfluidic channel |
| Scientific journals : Article | |||
| Physical, chemical, mathematical & earth Sciences : Chemistry Physical, chemical, mathematical & earth Sciences : Physics Engineering, computing & technology : Materials science & engineering | |||
| http://hdl.handle.net/10993/45604 | |||
| Cross-sectional focusing of red blood cells in a constricted microfluidic channel | |
| - | |
| Abay, Asena [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
| Recktenwald, Steffen M. [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
| John, Thomas [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
| Kaestner, Lars [Saarland Univ, Dept Expt Phys, Dynam Fluids, Saarbrucken, Germany.] | |
Wagner, Christian  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit] | |
| 2020 | |
| SOFT MATTER | |
| Royal Soc Chemistry | |
| 16 | |
| 2 | |
| 534-543 | |
| Yes | |
| 1744-683X | |
| Cambridge | |
| [en] Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of cell focusing in the channel cross-section remains poorly investigated. Here, we explore the cross-sectional distribution of living and rigid red blood cells passing a constricted microfluidic channel by tracking individual cells in multiple layers across the channel depth and across the channel width. While cells are homogeneously distributed in the channel cross-section pre-contraction, we observe a strong geometry-induced focusing towards the four channel faces post-contraction. The magnitude of this cross-sectional focusing effect increases with increasing Reynolds number for both living and rigid red blood cells. We discuss how this non-uniform cell distribution downstream of the contraction results in an apparent double-peaked velocity profile in particle image velocimetry analysis and show that trapping of red blood cells in the recirculation zones of the abrupt construction depends on cell deformability. | |
| Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [DFG FOR 2688 WA 1336/13-1] ; European Framework 'Horizon 2020' [675115] ; Volkswagen FoundationVolkswagen [Az: 93839] | |
| http://hdl.handle.net/10993/45604 | |
| 10.1039/c9sm01740b | |
| The research leading to these results has received funding from the Deutsche Forschungsgemeinschaft DFG FOR 2688 WA 1336/13-1, from the European Framework 'Horizon 2020' under grant agreement number 675115 (RELEVANCE) and from the Volkswagen Foundation (Az: 93839). |
| File(s) associated to this reference | ||||||||||||||
|
Fulltext file(s):
| ||||||||||||||
All documents in ORBilu are protected by a user license.
