| Reference : Lower plasma insulin levels during overnight closed loop in schoolchildren with type ... |
| Scientific journals : Article | |||
| Human health sciences : Endocrinology, metabolism & nutrition | |||
| http://hdl.handle.net/10993/38664 | |||
| Lower plasma insulin levels during overnight closed loop in schoolchildren with type 1 diabetes: potential advantage? | |
| English | |
| Schierloh, Ulrike [Pediatric Clinic/Centre Hospitalier de Luxembourg DECCP, Luxembourg] | |
| Wilinska, M. [Department of Paediatrics, University of Cambridge, Cambridge, UK] | |
Pit-Ten Cate, Ineke  [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Luxembourg Centre for Educational Testing (LUCET) >] | |
| Baumann, P. [Joanneum Research Forschungsgesellschaft, Graz, Austria] | |
| Hovorka, R. [Department of Paediatrics, University of Cambridge, Cambridge, UK] | |
| de Beaufort, Carine [Pediatric Clinic/Centre Hospitalier de Luxembourg DECCP, Luxembourg] | |
| 8-Mar-2019 | |
| PLoS ONE | |
| Public Library of Science | |
| 14 | |
| 3: e0212013 | |
| 1-11 | |
| Yes (verified by ORBilu) | |
| International | |
| 1932-6203 | |
| San Franscisco | |
| CA | |
| [en] diabetes Type 1 ; Closed loop ; Metabolic control ; children ; Randomised crossover design | |
| [en] Background
Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1 diabetes and their families. However, research so far has not reported insulin levels while comparing closed-loop to open-loop insulin delivery in children. Therefore, in this study we obtained glucose levels as well plasma insulin levels in children with type 1 diabetes to evaluate the efficacy of a model - based closed-loop algorithm compared to an open-loop administration. Methods Fifteen children with type 1 diabetes, 6-12 years, participated in this open-label single center study. We used a randomized cross over design in which we compared overnight closed-loop insulin delivery with sensor augmented pump therapy for two nights in both the hospital and at home (i.e., 1 night in-patient stay and at home per treatment condition). Only during the in-patient stay, hourly plasma insulin and blood glucose levels were assessed and are reported in this paper. Results Results of paired sample t-tests revealed that although plasma insulin levels were significantly lower during the closed-loop than in the open-loop (Mean difference 36.51 pmol/l; t(13)=2.13, p=.03, effect size d= 0.57), blood glucose levels did not vary between conditions (mean difference 0.76 mmol/l; t(13)=1.24, p=.12, d=0.37). The administered dose of insulin was significantly lower during the closed-loop compared with the open-loop (mean difference 0.10 UI; t(12)=2.45, p=.02, d=0.68). Conclusions Lower insulin doses were delivered in the closed-loop, resulting in lower plasma insulin levels , whereby glucose levels were not affected negatively. This suggests that the closed-loop administration is better targeted and hence could be more effective. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/10993/38664 | |
| 10.1371/journal.pone.0212013 | |
| FP7 ; 305343 - SPIDIMAN - Single-Port Insulin Infusion for Improved Diabetes Management |
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