Itaconic acid indicates cellular but not systemic immune system activation

Meiser, Johannes; Kraemer, Lisa; Jäger, Christian; Madry, Henning; Link, Andreas; Lepper, Philipp M.; Hiller, Karsten; Schneider, Jochen

doi:10.18632/oncotarget.25956

Reference : Itaconic acid indicates cellular but not systemic immune system activation


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/38455

Title :	Itaconic acid indicates cellular but not systemic immune system activation
Language :	English
Author, co-author :	Meiser, Johannes [> >]
	Kraemer, Lisa [> >]
	Jäger, Christian [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
	Madry, Henning [> >]
	Link, Andreas [> >]
	Lepper, Philipp M. [> >]
	Hiller, Karsten [> >]
	Schneider, Jochen [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Publication date :	2018
Journal title :	Oncotarget
Volume :	9
Issue/season :	63
Peer reviewed :	Yes
Audience :	International
ISSN :	1949-2553
Keywords :	[en] itaconic acid ; metabolism ; sepsis ; biomarker ; inflammation ; immunology
Abstract :	[en] Itaconic acid is produced by mammalian leukocytes upon pro-inflammatory activation. It appears to inhibit bacterial growth and to rewire the metabolism of the host cell by inhibiting succinate dehydrogenase. Yet, it is unknown whether itaconic acid acts only intracellularly, locally in a paracrine fashion, or whether it is even secreted from the inflammatory cells at meaningful levels in peripheral blood of patients with severe inflammation or sepsis. The aim of this study was to determine the release rate of itaconic acid from pro-inflammatory activated macrophages in vitro and to test for the abundance of itaconic acid in bodyfluids of patients suffering from acute inflammation. We demonstrate that excretion of itaconic acid happens at a low rate and that it cannot be detected in significant amounts in plasma or urine of septic patients or in liquid from bronchial lavage of patients with pulmonary inflammation. We conclude that itaconic acid may serve as a pro-inflammatory marker in immune cells but that it does not qualify as a biomarker in the tested body fluids.
Permalink :	http://hdl.handle.net/10993/38455
DOI :	10.18632/oncotarget.25956
Other URL :	http://www.oncotarget.com/fulltext/25956

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