Physics and Materials Science; Systems Biomedicine
http://hdl.handle.net/10993/35459
Fluctuating currents in stochastic thermodynamics. II. Energy conversion and nonequilibrium response in kinesin models
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Altaner, Bernhard[Georg-August-Universität Göttingen > Faculty of Physics > Institute for Nonlinear Dynamics > ; Max Planck Institute for Dynamics and Self-Organization > Dynamics of Complex Fluids]
Wachtel, Artur[University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit > ; Georg-August-Universität Göttingen > Faculty of Physics > Institute for Nonlinear Dynamics > ; Max Planck Institute for Dynamics and Self-Organization > Dynamics of Complex Fluids]
Vollmer, Jürgen[Georg-August-Universität Göttingen > Faculty of Physics > Institute for Nonlinear Dynamics > ; Max Planck Institute for Dynamics and Self-Organization > Dynamics of Complex Fluids]
[en] Unlike macroscopic engines, the molecular machinery of living cells is strongly affected by fluctuations. Stochastic thermodynamics uses Markovian jump processes to model the random transitions between the chemical and configurational states of these biological macromolecules. A recently developed theoretical framework [A. Wachtel, J. Vollmer, and B. Altaner, Phys. Rev. E 92, 042132 (2015)] provides a simple algorithm for the determination of macroscopic currents and correlation integrals of arbitrary fluctuating currents. Here we use it to discuss energy conversion and nonequilibrium response in different models for the molecular motor kinesin. Methodologically, our results demonstrate the effectiveness of the algorithm in dealing with parameter-dependent stochastic models. For the concrete biophysical problem our results reveal two interesting features in experimentally accessible parameter regions: the validity of a nonequilibrium Green-Kubo relation at mechanical stalling as well as a negative differential mobility for superstalling forces.
"Center for Earth System Research and Sustainability (CliSAP)" at the KlimaCampus Hamburg
The authors thank Nigel Goldenfeld, Matteo Polettini, and Massimiliano Esposito for insightful discussions. J.V. acknowledges support from a research grant from the "Center for Earth System Research and Sustainability (CliSAP)" at the KlimaCampus Hamburg, while the final version of this manuscript was drafted.
[University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit > ; Georg-August-Universität Göttingen > Faculty of Physics > Institute for Nonlinear Dynamics > ; Max Planck Institute for Dynamics and Self-Organization > Dynamics of Complex Fluids]
