Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease

Fitzgerald, Julia C.; Zimprich, Alexander; Bobbili, Dheeraj Reddy; Sharma, Manu; May, Patrick; Krüger, Rejko

doi:10.1093/brain/awx380

Reference : Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkin...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes Human health sciences : Neurology
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/34207

Title :	Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
Language :	English
Author, co-author :	Fitzgerald, Julia C. []
	Zimprich, Alexander []
	Bobbili, Dheeraj Reddy [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Sharma, Manu []
	May, Patrick [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Krüger, Rejko [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Publication date :	24-Jan-2018
Journal title :	Brain : A Journal of Neurology
Publisher :	Oxford University Press
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
ISSN :	0006-8950
e-ISSN :	1460-2156
City :	Oxford
Country :	United Kingdom
Keywords :	[en] Parkinson's disease ; TRAP1 ; Mutations
Abstract :	[en] Sir, In their letter in this issue, Gaare and colleagues (2018) state that TRAP1 may not be a Parkinson’s disease gene because of lack of genetic association. In response, we welcome their data analyses and we welcome any further genetic analyses of TRAP1 variants in additional Parkinson’s disease genetic datasets, including the reanalysis of open access datasets such as the Parkinson’s Progressive Markers Initiative (PPMI). Our point of view is that TRAP1 is an interesting effector protein that our study unequivocally showed is relevant to Parkinson’s disease signaling in the context of mitochondrial regulation. Furthermore, the overall contribution of TRAP1 genetic variants to Parkinson’s disease was not the focus of our recent paper in Brain (Fitzgerald et al., 2017).
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; University of Luxembourg: High Performance Computing - ULHPC
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/10993/34207
DOI :	10.1093/brain/awx380
Other URL :	https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awx380/4823739

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