Reference : Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR315...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/10993/32915

Title :	Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness
Language :	English
Author, co-author :	Galtsidis, Sotirios [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
	Logotheti, S. [Biomedical Applications Unit, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens, Greece]
	Pavlopoulou, A. [Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Efesiou Str., Athens, Greece]
	Zampetidis, C. P. [Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece]
	Papachristopoulou, G. [Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece]
	Scorilas, A. [Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece]
	Vojtesek, B. [Regional Center for Applied and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic]
	Gorgoulis, V. [Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece]
	Zoumpourlis, V. [Biomedical Applications Unit, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens, Greece]
Publication date :	1-Mar-2017
Journal title :	Cancer Letters
Publisher :	Elsevier Ireland Ltd
Volume :	388
Pages :	96-106
Peer reviewed :	Yes (verified by ORBilu)
ISSN :	03043835
Keywords :	[en] Anticancer targeting ; Epithelial–mesenchymal transition ; MIR3158 ; MIR34A ; Article ; MIR3158 gene ; MIR34A gene
Abstract :	[en] The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated networks which are commonly perturbed in cancer. Herein, we aimed to characterize a p73-regulated network that mediates cell migration and restores anti-oncogenic responses in p53-mutant cancer cells. In this study, we demonstrate that p73 regulates a network underlying cell migration, which consists of MIR34A/MIR3158/vimentin/β-catenin/lef1. The p73 isoforms transactivate the miRNA components (MIR34A/MIR3158) of this network, which in turn, downregulate their EMT-related mRNA co-targets (vimentin/β-catenin/lef1) to decrease cell-migration. Modulation of this network, by increasing the level of the novel p73-dependent target MIR3158, was found to induce anti-oncogenic/anti-invasive responses in p53-mutant cancer cells. Taken together, a p73-regulated, MIR3158-containing, network restores anti-invasive phenotypes in p53-mutant cancer cells; this property could be exploited towards the development of anticancer therapeutics. © 2016 Elsevier Ireland Ltd
Funders :	P206/12/G151, GACR, Grantová Agentura České Republiky
Permalink :	http://hdl.handle.net/10993/32915
DOI :	10.1016/j.canlet.2016.11.036

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