| Reference : Outcomes in patients with acute and stable coronary syndromes; insights from the pros... |
| Scientific journals : Article | |||
| Human health sciences : Cardiovascular & respiratory systems | |||
| http://hdl.handle.net/10993/27658 | |||
| Outcomes in patients with acute and stable coronary syndromes; insights from the prospective NOBORI-2 study | |
| - | |
| Fath-Ordoubadi, F. A [Manchester Heart Centre, Manchester Royal Infirmary, Manchester, United Kingdom] | |
| Spaepen, E. B [SBD Analytics, Hertstraat, Bekkevoort, Belgium] | |
| El-Omar, M. A [Division of Cardiology, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy] | |
| Fraser, D. G. A [Department of Cardiology, Rambam Medical Center, Haifa, Israel] | |
| Khan, M. A. A [European Medical and Clinical Division, Terumo Europe, Leuven, Belgium] | |
Neyses, Ludwig  [University of Luxembourg > Rectorate > Research Service] | |
| Danzi, G. B. C [> >] | |
| Roguin, A. D [> >] | |
| Paunovic, D. E [> >] | |
| Mamas, M. A. A F [> >] | |
| 2014 | |
| PLoS ONE | |
| Public Library of Science | |
| 9 | |
| 2 | |
| Yes (verified by ORBilu) | |
| 19326203 | |
| [en] acute coronary syndrome; adult; article; cardiovascular mortality; Charlson Comorbidity Index; female; heart death; heart disease; heart muscle revascularization; human; major clinical study; male; middle aged; multicenter study; non ST segment elevation myocardial infarction; outcome assessment; percutaneous coronary intervention; prognosis; prospective study; ST segment elevation myocardial infarction; stable angina pectoris ; Acute Coronary Syndrome; Aged; Angina ; Stable; Death; Demography; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Percutaneous Coronary Intervention; Proportional Hazards Models; Prospective Studies; Treatment Outcome | |
| [en] Background: Contemporary data remains limited regarding mortality and major adverse cardiac events (MACE) outcomes in patients undergoing PCI for different manifestations of coronary artery disease. Objectives: We evaluated mortality and MACE outcomes in patients treated with PCI for STEMI (ST-elevation myocardial infarction), NSTEMI (non ST-elevation myocardial infarction) and stable angina through analysis of data derived from the Nobori-2 study. Methods: Clinical endpoints were cardiac mortality and MACE (a composite of cardiac death, myocardial infarction and target vessel revascularization). Results: 1909 patients who underwent PCI were studied; 1332 with stable angina, 248 with STEMI and 329 with NSTEMI. Age-adjusted Charlson co-morbidity index was greatest in the NSTEMI cohort (3.78±1.91) and lowest in the stable angina cohort (3.00±1.69); P<0.0001. Following Cox multivariate analysis cardiac mortality was independently worse in the NSTEMI vs the stable angina cohort (HR 2.31 (1.10-4.87), p = 0.028) but not significantly different for STEMI vs stable angina cohort (HR 0.72 (0.16-3.19), p = 0.67). Similar observations were recorded for MACE (<180 days) (NSTEMI vs stable angina: HR 2.34 (1.21-4.55), p = 0.012; STEMI vs stable angina: HR 2.19 (0.97-4.98), p = 0.061. Conclusions: The longer-term Cardiac mortality and MACE were significantly worse for patients following PCI for NSTEMI even after adjustment of clinical demographics and Charlson co-morbidity index whilst the longer-term prognosis of patients following PCI STEMI was favorable, with similar outcomes as those patients with stable angina following PCI. © 2014 Fath-Ordoubadi et al. | |
| http://hdl.handle.net/10993/27658 | |
| 10.1371/journal.pone.0088577 | |
| http://www.scopus.com/inward/record.url?eid=2-s2.0-84895804919&partnerID=40&md5=9eb6a2a3a1e834770818978be12fbecb | |
| e88577
cited By 1 Scopus |
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