| Reference : Geographical variation of presentation at diagnosis of type 1 diabetes in children: t... |
| Scientific journals : Article | |||
| Human health sciences : Multidisciplinary, general & others | |||
| http://hdl.handle.net/10993/27212 | |||
| Geographical variation of presentation at diagnosis of type 1 diabetes in children: the EURODIAB Study | |
| English | |
| Levy-Marchal, C. [] | |
| Patterson, C.C. [] | |
| Green, A. [] | |
De Beaufort, Carine  [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| 2001 | |
| Diabetologia | |
| Springer Verlag | |
| 44 | |
| 3 | |
| B75-B80 | |
| Yes (verified by ORBilu) | |
| 0012-186X | |
| 1432-0428 | |
| Berlin | |
| Germany | |
| [en] type 1 diabetes ; diagnosis ; children ; geographical variation | |
| [en] We aimed to describe the frequency and degree of diabetic ketoacidosis in children across Europe at the time of diagnosis of Type I (insulin-dependent) diabetes mellitus and to determine if factors such as age and geographical region contribute to the risk of diabetic ketoacidosis.
METHODS: The study was part of the EURODIAB project. A total of 24 centres, covering a population at risk of more than 15 million children below 15 years of age, recruited 1,260 children at the time of clinical diagnosis. RESULTS: Polyuria, by far the most frequent symptom, was observed in 96% of the children. In only 25% of the children was the duration of symptoms less than 2 weeks and this proportion was larger in the under 5 year age-group (37 vs 22%; p < 0. 001). Of the 11 centres that recorded diabetic ketoacidosis status, the overall proportion with diabetic ketoacidosis (pH < 7.3) was 40% (95%-CI: 36-44%) in at least 90 % of cases. After stratification by centre, the odds ratio for diabetic ketoacidosis in the under 5 age-group was 1.02 (95%-CI:0.69-1.49) relative to the older children. There was significant variation between the 11 centres in the frequency of diabetic ketoacidosis which ranged from 26 to 67% (p = 0.002). An inverse correlation between the frequency of diabetic ketoacidosis and the background incidence rate was found in these centres (Spearman's rank correlation, rs = -0.715;p = 0.012). CONCLUSION/INTERPRETATION: Rising standards of medical information and greater awareness concurrent with an overall increase in incidence could have resulted in changes in the clinical presentation at onset of Type I childhood diabetes in Europe. | |
| EURODIAB ACA Study Group | |
| http://hdl.handle.net/10993/27212 |
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