Reference : The Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of...

	Document type :	Scientific congresses, symposiums and conference proceedings : Poster
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/2261

Title :	The Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of Disease-related Pathways
Language :	English
Author, co-author :	Ostaszewski, Marek [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Fujita, Kazuhiro [The Systems Biology Institute (SBI) - Japan]
	Matsuoka, Yukiko [The Systems Biology Institute (SBI) - Japan]
	Ghosh, Samik [The Systems Biology Institute (SBI) - Japan]
	Glaab, Enrico [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Trefois, Christophe [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Crespo, Isaac [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Perumal, Thanneer Malai [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Jurkowski, Wiktor [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Antony, Paul [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Diederich, Nico [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Buttini, Manuel [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Kolodkin, Alexey [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Kodama, Akihiko [Tokyo Medical and Dental University > Faculty of Medicine]
	Satagopam, Venkata [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Biryukov, Maria [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Eifes, Serge [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	del Sol Mesa, Antonio [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Schneider, Reinhard [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Kitano, Hiroaki [The Systems Biology Institute (SBI) - Japan]
	Balling, Rudi [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Publication date :	9-Mar-2013
Number of pages :	85x120cm
Peer reviewed :	Yes
On invitation :	No
Audience :	International
Event name :	The 11th International Conference on Alzheimer's & Parkinson's Diseases
Event date :	06-03-2013 to 10-03-2013
Event organizer :	AD/PD
Event place (city) :	Florence
Event country :	Italy
Keywords :	[en] Parkinson’s disease ; Molecular neuropathology ; Knowledge repository ; Bioinformatics
Abstract :	[en] Objectives: The pathogenesis of Parkinson's Disease (PD) is multi-factorial and age-related, implicating various genetic and environmental factors. It becomes increasingly important to develop new approaches to organize and explore the exploding knowledge of this field. Methods: The published knowledge on pathways implicated in PD, such as synaptic and mitochondrial dysfunction, alpha-synuclein pathobiology, failure of protein degradation systems and neuroinflammation has been organized and represented using CellDesigner. This repository has been linked to a framework of bioinformatics tools including text mining, database annotation, large-scale data integration and network analysis. The interface for online curation of the repository has been established using Payao tool. Results: We present the PD map, a computer-based knowledge repository, which includes molecular mechanisms of PD in a visually structured and standardized way. A bioinformatics framework that facilitates in-depth knowledge exploration, extraction and curation supports the map. We discuss the insights gained from PD map-driven text mining of a corpus of over 50 thousands full text PD-related papers, integration and visualization of gene expression in post mortem brain tissue of PD patients with the map, as well as results of network analysis. Conclusions: The knowledge repository of disease-related mechanisms provides a global insight into relationships between different pathways and allows considering a given pathology in a broad context. Enrichment with available text and bioinformatics databases as well as integration of experimental data supports better understanding of complex mechanisms of PD and formulation of novel research hypotheses.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Funders :	University of Luxembourg - UL
Name of the research project :	The Parkinson's Disease Map
Target :	Researchers ; Professionals ; Students ; Others
Permalink :	http://hdl.handle.net/10993/2261
Other URL :	http://adpd.ekonnect.co/ADPD_443/poster_53520/program.aspx
Commentary :	Presented by Christophe Trefois at the conference.

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Open access ADPD PD map poster v6.pdf Presented by Christophe Trefois Publisher postprint 4.67 MB View/Open

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