| Reference : Community-integrated omics links dominance of a microbial generalist to fine-tuned re... |
| Scientific journals : Article | |||
| Life sciences : Environmental sciences & ecology Life sciences : Genetics & genetic processes Life sciences : Microbiology | |||
| http://hdl.handle.net/10993/18965 | |||
| Community-integrated omics links dominance of a microbial generalist to fine-tuned resource usage | |
| English | |
Muller, Emilie  [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Pinel, Nicolas [> >] | |
| Laczny, Cedric Christian [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Hoopmann, Michael [> >] | |
| Narayanasamy, Shaman [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Lebrun, Laura [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Roume, Hugo [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Lin, Jake [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| May, Patrick [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Hicks, Nathan [> >] | |
| Buschart, Anna [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Wampach, Linda [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Liu, Cindy [> >] | |
| Price, Lance [> >] | |
| Gillece, John [> >] | |
| Guignard, Cédric [> >] | |
| Schupp, James [> >] | |
| Vlassis, Nikos [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Baliga [> >] | |
| Moritz, Robert [> >] | |
| Keim, Paul [> >] | |
| Wilmes, Paul [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Nov-2014 | |
| Nature Communications | |
| Nature Pub.lishing Group | |
| Yes (verified by ORBilu) | |
| International | |
| 2041-1723 | |
| London | |
| United Kingdom | |
| [en] Microbial communities are complex and dynamic systems that are primarily structured
according to their members’ ecological niches. To investigate how niche breadth (generalist versus specialist lifestyle strategies) relates to ecological success, we develop and apply an integrative workflow for the multi-omic analysis of oleaginous mixed microbial communities from a biological wastewater treatment plant. Time- and space-resolved coupled metabolomic and taxonomic analyses demonstrate that the community-wide lipid accumulation phenotype is associated with the dominance of the generalist bacterium Candidatus Microthrix spp. By integrating population-level genomic reconstructions (reflecting fundamental niches) with transcriptomic and proteomic data (realised niches), we identify finely tuned gene expression governing resource usage by Candidatus Microthrix parvicella over time. Moreover, our results indicate that the fluctuating environmental conditions constrain the accumulation of genetic variation in Candidatus Microthrix parvicella likely due to fitness trade-offs. Based on our observations, niche breadth has to be considered as an important factor for understanding the evolutionary processes governing (microbial) population sizes and structures in situ. | |
| Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; University of Luxembourg: High Performance Computing - ULHPC ; Luxembourg Centre for Systems Biomedicine (LCSB): Machine Learning (Vlassis Group) | |
| Researchers | |
| http://hdl.handle.net/10993/18965 | |
| 10.1038/ncomms6603 | |
| http://www.nature.com/ncomms/2014/141126/ncomms6603/full/ncomms6603.html |
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