| Reference : Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of my... |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/1319 | |||
| Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro. | |
| English | |
| Markus, M. A. [> >] | |
| Reichmuth, C. [> >] | |
| Atkinson, M. J. [> >] | |
| Reich, U. [> >] | |
| Hoffmann, I. [> >] | |
Balling, Rudi  [> >] | |
| Anderer, U. [> >] | |
| Hofler, H. [> >] | |
| 1999 | |
| Journal of Pathology | |
| 187 | |
| 2 | |
| 164-72 | |
| Yes (verified by ORBilu) | |
| 0022-3417 | |
| ENGLAND | |
| [en] Animals ; Blotting, Northern ; Blotting, Western ; Cadherins/metabolism ; Cell Culture Techniques ; Cell Differentiation/physiology ; Child ; Fluorescent Antibody Technique ; Humans ; Mice ; Mice, Inbred CBA ; Muscle, Skeletal/cytology/metabolism ; Neoplasm Proteins/metabolism ; Rhabdomyosarcoma/metabolism ; Tumor Cells, Cultured | |
| [en] Rhabdomyosarcomas bear a morphological and genetic resemblance to developing skeletal muscle. Apart from myogenic marker genes (bHLH factors, myosin, actin), cell adhesion molecules such as N-cadherin and N-CAM have been reported to be expressed both in rhabdomyosarcomas and during myogenesis. The present study demonstrates the expression of another cadherin, cadherin-11, in rhabdomyosarcomas and during differentiation of myoblasts in vitro: cadherin-11, a predominantly mesenchymal cell adhesion molecule, is highly expressed in embryonal rhabdomyosarcomas and alveolar rhabdomyosarcomas, which do not bear the Pax-3-FKHR fusion previously described. Cadherin-11 is down-regulated in normal skeletal muscle and after myotube formation in vitro. The results of this study suggest that cadherin-11 might be involved in myogenesis and that rhabdomyosarcomas may re-express or fail to down-regulate cadherin-11. Since alveolar rhabdomyosarcomas bearing the t(2;13) translocation do not express cadherin-11, it is postulated that Pax-3 and cadherin-11 might be linked and involved in the same myogenic pathway. | |
| http://hdl.handle.net/10993/1319 |
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