| Reference : Direct effects of nicotine on rabbit preimplantation embryos. |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/1251 | |||
| Direct effects of nicotine on rabbit preimplantation embryos. | |
| English | |
Balling, Rudi  [] | |
| Beier, H. M. [> >] | |
| 1985 | |
| Toxicology | |
| 34 | |
| 4 | |
| 309-13 | |
| Yes (verified by ORBilu) | |
| 0300-483X | |
| NETHERLANDS | |
| [en] Animals ; Blastocyst/drug effects/metabolism ; DNA/biosynthesis ; Embryonic and Fetal Development/drug effects ; Female ; Nicotine/toxicity ; Pregnancy ; Rabbits | |
| [en] The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure of rabbit preimplantation embryos to concentrations of nicotine higher than 1 X 10(-3) M results in a marked decrease in the in vitro development and in DNA-synthesis. Concentrations of nicotine below 1 X 10(-3) M have no effect on these early embryos. It can be concluded that the concentrations of nicotine which exert a direct embryotoxic effect are higher than the concentrations that may be expected in the blood circulation of humans considered to be "normal smokers". | |
| http://hdl.handle.net/10993/1251 |
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