S wie Stille

Article for general public (2012)

S’engager dans la culture œnophile. L’imbrication ordinaire entre la singularité des expériences et la collectivité des références

Scientific Conference (2008, July)

Partant du constat de la croissance de la réflexivité alimentaire en général, et de la culturalisation de la consommation de vin en particulier, je propose une analyse micro-sociologique de la pratique ... [more ▼]

Partant du constat de la croissance de la réflexivité alimentaire en général, et de la culturalisation de la consommation de vin en particulier, je propose une analyse micro-sociologique de la pratique discursive œnophile contemporaine, au Grand-Duché de Luxembourg, en me concentrant sur sa normativité inhérente et ses appropriations ordinaires. Cette articulation est constituée par la dégustation ‘pour débutant-e-s’, enseignée dans le cadre de la formation tout au long de la vie, institutionnalisée par l’Etat. La scientifisation (historiquement rationalisée) du jugement esthétique œnophile, véhiculant une normativité située et épistémique, est imbriquée dans des dynamiques hédoniques et éthiques de réalisation de soi : elle problématise et entend façonner les choix individuels. Ces derniers se construisent par des appropriations variées du canon œnophile véhiculé, liées à des différenciations socio-économiques et structurales (trajectoire, position sociale et genre), ainsi que – avant tout – culturelles et contextuelles (milieux d’élection, interactions, choix, techniques et expérimentations effectuées dans un projet de subjectivation). Par l’analyse d’un point de friction et de négociation entre les pratiques discursives ‘ordinaires’ et leur pendant ‘ambiant’, on aperçoit les mécanismes de la fabrication du lien social abstrait à partir des liens concrets, toujours potentiellement compétitifs/sélectifs (créant du pouvoir) ou sublimés/créatifs (créant du sens). [less ▲]

An S-adic characterization of minimal subshifts with first difference of complexity 1 <=p(n+1)-p(n)<=2

E-print/Working paper (2013)

S-adic characterization of sequence with complexity 2n

Presentation (2014, April)

S-adic representations using Rauzy graphs

Scientific Conference (2012, July)

S-GHOST: Un modèle d'auto-organisation de l'étalement urbain et du réseau de transport

in Antoni, Jean-Philippe (Ed.) Modéliser la ville: formes urbaines et politiques de transport (2011)

S-Nav: Semantic-Geometric Planning for Mobile Robots

Scientific Conference (2023, July 10)

s. v. Lady Diana

in Wodianka, Stephanie; Ebert, Juliane (Eds.) Metzler Lexikon moderner Mythen: Figuren, Konzepte, Ereignisse (2014)

S100A8/A9 AND MIR-132-5P: TWO KEY PLAYERS IN THE REGULATION OF CA2+-DEPENDENT CYTOKINE SECRETION IN NEUTROPHILS

Doctoral thesis (2022)

Neutrophils are important actors of the immune system, particularly through the release of cytokines in the inflammatory environment. This process must be highly orchestrated to avoid cell overactivation ... [more ▼]

Neutrophils are important actors of the immune system, particularly through the release of cytokines in the inflammatory environment. This process must be highly orchestrated to avoid cell overactivation and unwanted tissue damage. However, this elegant regulation is still only partially known and poorly characterized. Increasing evidence over the years show that Ca2+ is actively involved in cytokine secretion but our knowledge on the relationship between these two phenomena needs to be filled. To this end, in this study, we investigated the Ca2+-dependent mechanisms underlying cytokine secretion in neutrophils. For that, the differentiated myeloid cell line HL-60 (dHL-60) was used as a cell model since primary neutrophils are unable to be genetically modified. Our results showed that the mobilization of several cytokines, notably IL-8, was up-regulated in a time-dependent manner by a pro-inflammatory stimulus (fMLF). Experiments of intracellular flow cytometry staining provided evidence on the presence of preformed IL-8 as well as de novo synthesis of IL-8. Changes in intracellular Ca2+ levels, resulting from an extracellular Ca2+ entry, is shown to be indispensable for efficient secretion of CCL2, CCL3, CCL4 and IL-8, even if an additional signal appears to be required for the release of IL-8. Ca2+-dependent cytokine secretion was associated to the store-operated Ca2+ entry (SOCE) mechanism and probably relies on the Ca2+ sensor STIM1. Since Ca2+-binding proteins S100A8/A9 have been previously reported to be key actors in the regulation of neutrophil NADPH oxidase activation, we hypothesized that Ca2+ signals could be converted into cytokine secretion through intracellular S100A8/A9. Knockdown studies performed in mouse (Hoxb8 cells) and human (dHL-60) neutrophil models confirmed the involvement of S100A8/A9 in the regulation of cytokine secretion. Moreover, our data support the fact that a part of cytokine secretion occurs through the degranulation process. Finally, we investigated the post-transcriptional mechanism involved in the regulation of S100A8/A9 expression and thus, in the control of cytokine secretion. Based on prediction network analysis, miR-132-5p was identified as a potential regulator of S100A8/A9. Stable overexpression of miR-132-5p in dHL-60 cells caused a strong inhibition of S100A8/A9 expression and IL-8 secretion underlining the preponderant role of miR-132-5p-regulated S100A8/A9 expression in the pro-inflammatory response. To summarize, for the first time, we prove that Ca2+-dependent cytokine secretion is associated with SOCE and is regulated by intracellular S100A8/A9, which is negatively modulated by miR-132-5p to prevent excessive neutrophil activation and host damage. [less ▲]

Sa-TikZ: a library to draw switching architectures

in Ars TeXnica (2013), 15

The article illustrates how it is possible to draw some types of switching architectures in a simple manner. The Sa-TikZ library provides not only the keys devoted to the drawing part, but also the keys ... [more ▼]

The article illustrates how it is possible to draw some types of switching architectures in a simple manner. The Sa-TikZ library provides not only the keys devoted to the drawing part, but also the keys devoted to customize the aspect of the architectures in the spirit of the TikZ syntax. [less ▲]