![]() ![]() ; Bueb, Jean-Luc ![]() in Trends in Pharmacological Sciences (1990), 11(9), 358-62 The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these ... [more ▼] The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these effects are inhibited by pertussis toxin and involve a transient increase in IP3, no selective membrane receptors have been identified. However, it has recently been shown that these compounds activate G proteins in vitro. Here Yves Landry and colleagues discuss the proposal that direct activation of G protein is the physiological mechanism of action of substance P on rat peritoneal mast cells, this mechanism being mimicked by mastoparan and 48/80, and possibly by other cationic amphiphilic peptides such as kinins. These compounds might be of help in defining the interaction between membrane receptors and G proteins. [less ▲] Detailed reference viewed: 148 (0 UL)![]() Gawron, Piotr ![]() in Bulletin of the Polish Academy of Sciences. Technical Sciences (2014) Detailed reference viewed: 141 (0 UL)![]() Damoun, Farouk ![]() ![]() Scientific Conference (2023, March 27) Graph related tasks, such as graph classification and clustering, have been substantially improved with the advent of graph neural networks (GNNs). However, existing graph embedding models focus on ... [more ▼] Graph related tasks, such as graph classification and clustering, have been substantially improved with the advent of graph neural networks (GNNs). However, existing graph embedding models focus on homogeneous graphs that ignore the heterogeneity of the graphs. Therefore, using homogeneous graph embedding models on heterogeneous graphs discards the rich semantics of graphs and achieves average performance, especially by utilizing unlabeled information. However, limited work has been done on whole heterogeneous graph embedding as a supervised task. In light of this, we investigate unsupervised distributed representations learning on heterogeneous graphs and propose a novel model named G-HIN2Vec, Graph-Level Heterogeneous Information Network to Vector. Inspired by recent advances of unsupervised learning in natural language processing, G-HIN2Vec utilizes negative sampling technique as an unlabeled approach and learns graph embedding matrix from different predefined meta-paths. We conduct a variety of experiments on three main graph downstream applications on different socio-demographic cardholder features, graph regression, graph clustering, and graph classification, such as gender classification, age, and income prediction, which shows superior performance of our proposed GNN model on real-world financial credit card data. [less ▲] Detailed reference viewed: 86 (16 UL)![]() ![]() ; Bueb, Jean-Luc ![]() in Agents and Actions (1991), 33(1-2), 81-3 The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin ... [more ▼] The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin (100 ng/ml) inhibited histamine release induced by compound 48/80, substance P, mastoparan, peptide 401, bradykinin and spermine showing that a G-protein sensitive to pertussis toxin was involved in the non-immunological histamine release. All these compounds directly activate purified G-proteins. The sensitivity to pertussis toxin of this direct stimulatory effect was demonstrated for compound 48/80, mastoparan and substance P. Altogether these results suggest that a direct activation of G-protein might be the molecular mechanism of action of histamine secretagogues acting through a pertussis toxin sensitive G-protein and in this way mimic agonist-ligand receptor interaction. [less ▲] Detailed reference viewed: 141 (1 UL)![]() ; ; et al in American Journal of Psychiatry (2008), 165(6), 753-762 Detailed reference viewed: 44 (0 UL)![]() ; ; et al in Cell Genomics (2021), 1(2), Detailed reference viewed: 47 (0 UL)![]() ; ; et al in ASDAM 2012, The Ninth International Conference on Advanced Semiconductor Devices and Microsystems (2012) Detailed reference viewed: 176 (0 UL)![]() ; Marso, Michel ![]() in Applied Physics Letters (2006), 89 The authors report on the fabrication and characterization of photodetectors based on nitrogen-ion-implanted GaAs and the annealing dynamics in these devices. An energy of 400 keV was used to implant N ... [more ▼] The authors report on the fabrication and characterization of photodetectors based on nitrogen-ion-implanted GaAs and the annealing dynamics in these devices. An energy of 400 keV was used to implant N ions in a GaAs substrate at an ion concentration of 1 1016 cm−2. Dark current measurements as well as measurements under illumination show that the material properties rapidly change during the annealing process. Photodetectors based on nitrogen-implanted GaAs materials with annealing temperatures up to 400 °C exhibit a subpicosecond carrier lifetime up to 0.6 ps. These properties make nitrogen-ion-implanted GaAs an ideal material for ultrafast photodetectors, as alternative to low-temperature-grown GaAs. [less ▲] Detailed reference viewed: 120 (1 UL)![]() ![]() Hanesch, Ulrike ![]() in Pain (2003), 104 Detailed reference viewed: 96 (0 UL)![]() Cuniberti, Gilles ![]() in Petites Affiches, la Loi (1999) Detailed reference viewed: 99 (0 UL)![]() Moreau, Sebastien ![]() in Mouvement Social (2016), 254 This article deals with the emergence of a group of professional automobile pilots in Europe during the Interwar period. During the time, automobile racing was institutionalised and commercialised to a ... [more ▼] This article deals with the emergence of a group of professional automobile pilots in Europe during the Interwar period. During the time, automobile racing was institutionalised and commercialised to a previously unknown extent, under the supervision of European automobile clubs, industrial groups and journalists. In this context, by following the trajectories of pilots, we study the conditions for exercising this practice – part sport, part social activity. These trajectories are mainly marked by a wide diversity due to the sport’s origins, at the crossroads of changes in bourgeois leisure activities and the unprecedented development of the automobile industry. On the roads and race tracks of Europe, racing team pilots came up against wealthy independent racers, forming a stratified population and a wide range of participants with diverse origins, mobility, motivations and compensation. In the representations of the period, the pilots became the icons of the triumph of the automobile, but they nevertheless took second stage to the industrial groups that employed and equipped them. In this European space that was driven across and appropriated, behind the sports competition that acted as a support, this situation gave rise to large-scale industrial competitions and strategies that benefited the sportsmen but also held them captive. [less ▲] Detailed reference viewed: 141 (2 UL)![]() Machado Carneiro, Joël ![]() Presentation (2016) Detailed reference viewed: 97 (0 UL)![]() Machado Carneiro, Joël ![]() Scientific Conference (2015) Detailed reference viewed: 69 (3 UL)![]() Machado Carneiro, Joël ![]() Presentation (2016, May) Detailed reference viewed: 146 (5 UL)![]() Machado Carneiro, Joël ![]() Presentation (2016, April) Detailed reference viewed: 69 (4 UL)![]() Marso, Michel ![]() in Proceedings of the 18th European Solid State Device Research Conference (ESSDERC 88), Montpellier, France, 1988, J. de Physique, Colloque C4, suppl. 9 (1988) Detailed reference viewed: 115 (0 UL)![]() Marso, Michel ![]() in Electronics Letters (1989), 25(1989), 1462-1463 Detailed reference viewed: 99 (0 UL)![]() Marso, Michel ![]() in Electronics Letters (1991), 27(1991), 335-337 Detailed reference viewed: 94 (0 UL)![]() Ferring, Dieter ![]() ![]() Scientific Conference (2017) Caring for a close person involves and impacts several aspects and domains of personal life. A scenario that is often sketched here indicates that caring is physically exhausting, demanding time, leaving ... [more ▼] Caring for a close person involves and impacts several aspects and domains of personal life. A scenario that is often sketched here indicates that caring is physically exhausting, demanding time, leaving no time for leisure, and excluding the carer from further social activities. In this view, caring is strain as it is clearly described by the concept of caregiver burden, and a risk for the psychological and/or physical health of family carers. But caring may also have another side of positive gratification and of fulfilment. To care for another person may represent a meaningful work for both the cared for and the caring person that may also go along with recognition and positive feedback from others. This is the starting point of the present study that addressed a sample of 151 informal carers (n = 111 female) with a mean age of 58 years (SD=14 years) with self-report questionnaire. The measure offered in a first part positive (n=35) and negative aspects (n=23) of caring for a close person and subjects had to rate how much they agree that these aspects are present in their own care giving relationship. Moreover, life satisfaction as well as positive and negative affect were assessed in a second part. Multivariate analyses by factor as well as cluster analyses showed different profiles of gains and losses that were systematically linked to indicators of subjective well-being. Findings will be discussed with respect to their implications for psychosocial intervention in the field of informal care. [less ▲] Detailed reference viewed: 95 (6 UL) |
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