1867, Napoléon III, Bismarck et un record

Article for general public (2017)

Das 19. Jahrhundert als Mediengesellschaft

in MEDIENwissenschaft: Rezensionen, Reviews (2010), (02), 195-197

1916 - eine Zeit der sozialen Kämpfe beginnt in Luxemburg. Die Gründung des Berg- und Hüttenarbeiterverbandes sowie des Metallarbeiterverbandes

Article for general public (1991)

1918, 1945, 1989: Childhood in Times of Political Transformation: Part II

in Journal of Modern European History (2021), 19

1919: Quel avenir pour la monarchie?

in Muller, Jean-Claude (Ed.) 100 Joer Lëtzebuerger Dynastie : collections et souvenirs de la Maison grand-ducale. Catalogue de l’exposition au Musée national d’histoire et d’art, (1990)

The 1968 Movement Revisited – Education and the Distinction in Values, Political Interest and Political Participation in West Germany

in German Politics (2009), 18(2), 180-200

The aim of this paper is to take a look at the 1968 generation in West Germany about 40 years after the 1968 events. Whether there was a 1968 generation in the narrow sense of the word will be explored ... [more ▼]

The aim of this paper is to take a look at the 1968 generation in West Germany about 40 years after the 1968 events. Whether there was a 1968 generation in the narrow sense of the word will be explored. While comparing the 1968 generation with earlier and later cohorts, political interest, political activity and (postmaterialist) values will be analysed. Education will be theorised as a main mechanism that distinguishes the 1968 generation from earlier generations. Quantitative analyses will be performed employing a temporal perspective and including age, period and cohort effects - so that socialisation as well as individual change over the life cycle and macro influences can be taken into account. The results show a strong influence of education on political interest, political activity and postmaterialism. Therefore, what is called the '1968 generation' only applies to the more highly educated people of this generation. [less ▲]

1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation.

in Blood (2005), 106(13), 4351-8

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 ... [more ▼]

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 is known to mediate predominantly immunosuppressive responses in vitro and in vivo. It has been demonstrated that macrophages can produce 1alpha,25(OH)2D3 on activation with interferon gamma (IFN-gamma), although little is understood about the biologic significance of this response. We show here that 1alpha,25(OH)2D3 can selectively suppress key effector functions of IFN-gamma-activated macrophages. Among these are the suppression of listericidal activity, the inhibition of phagocyte oxidase-mediated oxidative burst, and the suppression of important IFN-gamma-induced genes, including Ccl5, Cxcl10, Cxcl9, Irf2, Fcgr1, Fcgr3, and Tlr2. The deactivation of IFN-gamma-stimulated macrophages is dependent on a functional vitamin D receptor and 1alpha,25(OH)2D3 acts specifically on IFN-gamma-activated macrophages, whereas the steroid has no effects on resting macrophages. Therefore, the 1alpha,25(OH)2D3-mediated suppression of macrophage functions is distinct from previously described macrophage deactivation mechanisms. In conclusion, our data indicate that the production of 1alpha,25(OH)2D3 by IFN-gamma-stimulated macrophages might be an important negative feedback mechanism to control innate and inflammatory responses of activated macrophages. [less ▲]

2 août 1980, 10.25 h

Article for general public (2020)

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

in Bioorganic & Medicinal Chemistry Letters (2014), 24(17), 4151-4157

The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease. In this study ... [more ▼]

The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease. In this study, we investigated a series of 2-alkynoic fatty acids (2-AFAs) with chain lengths between 14 and 18 carbon atoms for dual in vitro activity against both life stages. 2-Octadecynoic acid (2-ODA) was identified as the best inhibitor of Plasmodium berghei parasites with ten times higher potency (IC50 = 0.34 μg/ml) than the control drug. In target determination studies, the same compound inhibited three Plasmodium falciparum FAS-II (PfFAS-II) elongation enzymes PfFabI, PfFabZ, and PfFabG with the lowest IC50 values (0.28-0.80 μg/ml, respectively). Molecular modeling studies provided insights into the molecular aspects underlying the inhibitory activity of this series of 2-AFAs and a likely explanation for the considerably different inhibition potentials. Blood stages of P. falciparum followed a similar trend where 2-ODA emerged as the most active compound, with 20 times less potency. The general toxicity and hepatotoxicity of 2-AFAs were evaluated by in vitro and in vivo methods in mammalian cell lines and zebrafish models, respectively. This study identifies 2-ODA as the most promising antiparasitic 2-AFA, particularly towards P. berghei parasites. © 2014 Elsevier Ltd. All rights reserved. [less ▲]

2. Bildungsbericht Stadt Trier 2012

Report (2013)

"Das Trierer Bildungsmonitoring hat seit 2010 die Aufgabe, das kommunale Bildungsgeschehen kontinuierlich zu erfassen. […] Über die im Bildungsmonitoring gesammelten Indikatoren sollen die interessierte ... [more ▼]

"Das Trierer Bildungsmonitoring hat seit 2010 die Aufgabe, das kommunale Bildungsgeschehen kontinuierlich zu erfassen. […] Über die im Bildungsmonitoring gesammelten Indikatoren sollen die interessierte Öffentlichkeit, die Verwaltung, die Politik und die Bildungsakteure in regelmäßigen Abständen unterrichtet werden. Eine Form dafür ist der Bildungsbericht, der im Abstand von zwei Jahren erscheint. Der Bildungsbericht gibt einen Überblick über die Bandbreite der gesammelten Indikatoren und fokussiert dabei das Bildungsgeschehen jeweils unter einem thematischen Schwerpunkt." Schwerpunkt des zweiten Trierer Bildungsberichtes ist das Thema "Bildung und Geschlecht". [less ▲]