Le cadre juridique européen des services à la demande: Quelle directive pour quels services?

in La réglementation des services audiovisuels à la demande: chaos ou cohérence? (2011)

Cadre, image et connaissance : Sur les formes du film et les gestes de son analyse

in La part de l'oeil (2020), 33-34

Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies.

in Diabetologia (2008), 51(5), 726-35

AIMS/HYPOTHESIS: The aim of this study was to investigate the evidence of an increased risk of childhood-onset type 1 diabetes in children born by Caesarean section by systematically reviewing the ... [more ▼]

AIMS/HYPOTHESIS: The aim of this study was to investigate the evidence of an increased risk of childhood-onset type 1 diabetes in children born by Caesarean section by systematically reviewing the published literature and performing a meta-analysis with adjustment for recognised confounders. METHODS: After MEDLINE, Web of Science and EMBASE searches, crude ORs and 95% CIs for type 1 diabetes in children born by Caesarean section were calculated from the data reported in each study. Authors were contacted to facilitate adjustments for potential confounders, either by supplying raw data or calculating adjusted estimates. Meta-analysis techniques were then used to derive combined ORs and to investigate heterogeneity between studies. RESULTS: Twenty studies were identified. Overall, there was a significant increase in the risk of type 1 diabetes in children born by Caesarean section (OR 1.23, 95% CI 1.15-1.32, p < 0.001). There was little evidence of heterogeneity between studies (p = 0.54). Seventeen authors provided raw data or adjusted estimates to facilitate adjustments for potential confounders. In these studies, there was evidence of an increase in diabetes risk with greater birthweight, shorter gestation and greater maternal age. The increased risk of type 1 diabetes after Caesarean section was little altered after adjustment for gestational age, birth weight, maternal age, birth order, breast-feeding and maternal diabetes (adjusted OR 1.19, 95% CI 1.04-1.36, p = 0.01). CONCLUSIONS/INTERPRETATION: This analysis demonstrates a 20% increase in the risk of childhood-onset type 1 diabetes after Caesarean section delivery that cannot be explained by known confounders. [less ▲]

Cahiers de fiscalité luxembourgeoise et européenne

in Cahiers de fiscalité luxembourgeoise et européenne (2023), 2(1), 209

Les Cahiers de fiscalité luxembourgeoise et européenne offrent une analyse rigoureuse et thématique du droit fiscal luxembourgeois. Associant les exigences de la recherche scientifique à la réalité de la ... [more ▼]

Les Cahiers de fiscalité luxembourgeoise et européenne offrent une analyse rigoureuse et thématique du droit fiscal luxembourgeois. Associant les exigences de la recherche scientifique à la réalité de la pratique administrative luxembourgeoise, les Cahiers proposent deux fois par an une sélection d'analyses doctrinales rédigées par des experts luxembourgeois et étrangers. Chaque numéro des Cahiers se fait également le reflet d'une analyse systémique de la jurisprudence fiscale la plus récente au niveau national - contributions directes (juridictions administratives) et fiscalité indirecte (juridictions judiciaires) - et au niveau supranational (CJUE, CEDH). La recherche en droit fiscal luxembourgeois étant au coeur de ce projet collectif éditorial, les Cahiers publient régulièrement des actes de colloques, des extraits de thèses de doctorat récemment soutenues et un travail pluriannuel de rédaction de commentaires de la loi générale des impôts (Abgabenordnung). [less ▲]

Cahiers de fiscalité luxembourgeoise et européenne - 2022/2

in Cahiers de fiscalité luxembourgeoise et européenne (2022), 1(2), 245

Les Cahiers de fiscalité luxembourgeoise et européenne offrent une analyse rigoureuse et thématique du droit fiscal luxembourgeois. Associant les exigences de la recherche scientifique à la réalité de la ... [more ▼]

Les Cahiers de fiscalité luxembourgeoise et européenne offrent une analyse rigoureuse et thématique du droit fiscal luxembourgeois. Associant les exigences de la recherche scientifique à la réalité de la pratique administrative luxembourgeoise, les Cahiers proposent deux fois par an une sélection d'analyses doctrinales rédigées par des experts luxembourgeois et étrangers. Chaque numéro des Cahiers se fait également le reflet d'une analyse systémique de la jurisprudence fiscale la plus récente au niveau national - contributions directes (juridictions administratives) et fiscalité indirecte (juridictions judiciaires) - et au niveau supranational (CJUE, CEDH). La recherche en droit fiscal luxembourgeois étant au coeur de ce projet collectif éditorial, les Cahiers publient régulièrement des actes de colloques, des extraits de thèses de doctorat récemment soutenues et un travail pluriannuel de rédaction de commentaires de la loi générale des impôts (Abgabenordnung). [less ▲]

Calabi-Yau structures for multiplicative preprojective algebras

in Journal of Noncommutative Geometry (in press)

Calabi-Yau structures on (quasi)-bisymplectic algebras

E-print/Working paper (n.d.)

Calcineurin in human heart hypertrophy.

in Circulation (2002), 105(19), 2265-9

BACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be ... [more ▼]

BACKGROUND: In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be elevated in the myocardium of patients with congestive heart failure. In contrast, few data are available about calcineurin activity in patients with pressure overload or cardiomyopathic hypertrophy who are not in cardiac failure. METHODS AND RESULTS: We investigated calcineurin activity and protein expression in 2 different forms of cardiac hypertrophy: hypertrophic obstructive cardiomyopathy (HOCM) and aortic stenosis (AS). We found that the C-terminus of calcineurin A protein containing the autoinhibitory domain was less abundant in myocardial hypertrophy than in normal heart, which suggests the possibility of proteolysis. No new splice variants could be detected by reverse-transcription polymerase chain reaction. This resulted in a significant elevation of calcineurin enzymatic activity in HOCM and AS compared with 6 normal hearts. Increased calcineurin phosphatase activity caused increased migration of NF-AT2 (nuclear factor of activated T cells 2) in SDS-PAGE compatible with pronounced NF-AT dephosphorylation in hypertrophied myocardial tissue. CONCLUSIONS: Hypertrophy in HOCM and AS without heart failure is characterized by a significant increase in calcineurin activity. This might occur by (partial) proteolysis of the calcineurin A C-terminus containing the autoinhibitory domain. Increased calcineurin activity has functional relevance, as shown by altered NF-AT phosphorylation state. Although hypertrophy in AS and HOCM may be initiated by different upstream triggers (internal versus external fiber overload), in both cases, there is activation of calcineurin, which suggests an involvement of this pathway in the pathogenesis of human cardiac hypertrophy. [less ▲]

Calcitonin gene-related peptide immunreaktive Nervenfasern in der Dura mater der Ratte. Experimente zur neurogenen Entzündung der Hirnhäute.

in Der Schmerz (1995), 9(1), 20-28

Calcitonin gene-related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat.

in Canadian Journal of Physiology & Pharmacology (1995)