Bullying

Presentation (2019, February)

Bullying in Schulen Prädiktoren zivilcouragierten Verhaltens

Book published by VDM Verlag Dr. Müller (2008)

Bundesweite Befragung von Medizinstudierenden zu ihren Berufserwartungen

in Fuchs, Christoph; Koch, Thea; Scriba, Peter C. (Eds.) Perspektiven junger Ärztinnen und Ärzte in der Patientenversorgung (2013)

BUONA DOMENICA ODER „ITALIEN KOMMT ZU UNS“ Reise um ein italo-luxemburgisches Medienphänomen

in Arts et lettres (2017), (5), 21-32

Buona fede e giusto processo: presunti limiti alla frazionabilità della domanda giudiziale del lavoratore

in Rivista Italiana di Diritto del Lavoro (2009)

Burden of cardiovascular disease across 29 countries and GPs’ decision to treat hypertension in oldest-old

in Scandinavian Journal of Primary Health Care (2018)

Objectives: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in ... [more ▼]

Objectives: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) burden and life expectancy could explain the differences. Design: This is a survey study using case-vignettes of oldest-old patients with different comorbidities and blood pressure levels. An ecological multilevel model analysis was performed. Setting: GP respondents from European General Practice Research Network (EGPRN) countries, Brazil and New Zeeland. Subjects: This study included 2543 GPs from 29 countries. Main outcome measures: GP treatment probability to start or not start antihypertensive treatment based on responses to case-vignettes; either low (<50% started treatment) or high (!50% started treatment). CVD burden is defined as ratio of disability-adjusted life years (DALYs) lost due to ischemic heart disease and/or stroke and total DALYs lost per country; life expectancy at age 60 and prevalence of oldest-old per country. Results: Of 1947 GPs (76%) responding to all vignettes, 787 (40%) scored high treatment probability and 1160 (60%) scored low. GPs in high CVD burden countries had higher odds of treatment probability (OR 3.70; 95% confidence interval (CI) 3.00–4.57); in countries with low life expectancy at 60, CVD was associated with high treatment probability (OR 2.18, 95% CI 1.12–4.25); but not in countries with high life expectancy (OR 1.06, 95% CI 0.56–1.98). Conclusions: GPs’ choice to treat/not treat hypertension in oldest-old was explained by differences in country-specific health characteristics. GPs in countries with high CVD [less ▲]

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study

in EBioMedicine (2021), 66(103309),

Background: tinnitus is a heterogeneous condition associated with audio logical and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability ... [more ▼]

Background: tinnitus is a heterogeneous condition associated with audio logical and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggregation studies. The genetic contribution to severe tinnitus is unknown since large genomic studies include individuals with self-reported tinnitus and large heterogeneity in the phenotype. The aim of this study was to identify genes for severe tinnitus in patients with extreme phenotype. Methods: for this extreme phenotype study, we used three different cohorts with European ancestry (Spanish with Meniere disease (MD), Swedish tinnitus and European generalized epilepsy). In addition, four independent control datasets were also used for comparisons. Whole-exome sequencing was performed for the MD and epilepsy cohorts and whole-genome sequencing was carried out in Swedish with tinnitus. Findings: we found an enrichment of rare missense variants in 24 synaptic genes in a Spanish cohort, the most significant being PRUNE2, AKAP9, SORBS1, ITGAX, ANK2, KIF20B and TSC2 (p < 2E−04), when they were compared with reference datasets. This burden was replicated for ANK2 gene in a Swedish cohort with 97 tinnitus individuals, and in a subset of 34 Swedish patients with severe tinnitus for ANK2, AKAP9 and TSC2 genes (p < 2E−02). However, these associations were not significant in a third cohort of 701 generalized epilepsy individuals without tinnitus. Gene ontology (GO) and gene-set enrichment analyses revealed several pathways and biological processes involved in severe tinnitus, including membrane trafficking and cytoskeletal protein binding in neurons. Interpretation: a burden of rare variants in ANK2, AKAP9 and TSC2 is associated with severe tinnitus. ANK2, encodes a cytoskeleton scaffolding protein that coordinates the assembly of several proteins, drives axonal branching and influences connectivity in neurons. [less ▲]

Burg, Stadt, Festung, Großstadt. Die Entwicklung der Stadt Luxemburg vom 10. bis zum 20. Jahrhundert

in Bousch, Patrick; Schulz, Christian; Chilla, Tobias (Eds.) et al Der Luxemburg Atlas / Atlas du Luxembourg (2009)

Bürgerfreiheiten im Interesse des Stadtherrn? Das Freiheitsprivileg von 1244 für die Stadt Luxemburg

in Reichert, Winfried; Minn, Gisela; Voltmer, Rita (Eds.) Quellen zur Geschichte des Rhein-Maas-Raumes: Ein Lehr- und Lernbuch (2006)

Bürgerliche Hausmusik. Besprechung zu der Inszenierung von Hauptmanns "Einsame Menschen" und Schillers "Kabale und Liebe" am Schauspielhaus Bochum

in Theater heute (2015)