Building a kinetic model of trehalose biosynthesis in Saccharomyces cerevisiae.

in Methods in Enzymology (2011), 500

In this chapter, we describe the steps needed to create a kinetic model of a metabolic pathway based on kinetic data from experimental measurements and literature review. Our methodology is presented by ... [more ▼]

In this chapter, we describe the steps needed to create a kinetic model of a metabolic pathway based on kinetic data from experimental measurements and literature review. Our methodology is presented by utilizing the example of trehalose metabolism in yeast. The biology of the trehalose cycle is briefly reviewed and discussed. [less ▲]

Building a new model of oral sources on European integration

Scientific Conference (2016, July 09)

Building on the innovative scholarly production models developed by the CVCE, this contribution explores the conceptual framework and the exploitation for research and knowledge transfer purposes of ... [more ▼]

Building on the innovative scholarly production models developed by the CVCE, this contribution explores the conceptual framework and the exploitation for research and knowledge transfer purposes of audiovisual sources, in particular in-depth interviews with key individual players of the European integration process. The interviews are chiefly conducted for research purposes, namely to provide new primary sources as complementary material to written text that can help to contrast and refine research findings, and also as a source of corroborative evidence that can offer unique insights given the nature of the medium and provide a “behind-the-scenes” view of European integration. It can be also seen as a cross-cutting method that fosters interdisciplinary and holistic approaches. [less ▲]

Building a Smart Nation: Luxembourg Tackling the Fourth Industrial Revolution

Presentation (2022, May 17)

Beginning in the 20th century, Luxembourg experienced several periods of transition. The largely agriculture-based economy became industrialized, driven by a powerful steel industry which remained the ... [more ▼]

Beginning in the 20th century, Luxembourg experienced several periods of transition. The largely agriculture-based economy became industrialized, driven by a powerful steel industry which remained the dominant sector from the immediate post-Second World War years to the mid-1970s. In 1974 the steel industry began to decline, marking the end of the ‘Trente Glorieuses’. Luxembourg was forced to implement considerable structural changes and embarked on its second major transition, from an industrial economy to a service economy based on the financial sector. To guarantee its future position in a competitive globalized environment, the country needed to diversify its economy by focusing on state-of-the-art fields with high added value, while preserving the competitiveness of the financial sector. Luxembourg continued to prioritize innovation as the main driver of sustainable and inclusive growth, embarking on its digital transition in order to build a "smart nation". [less ▲]

Building a virtual ligand screening pipeline using free software: a survey

in Briefings in Bioinformatics (2015)

Virtual screening, the search for bioactive compounds via computational methods, provides a wide range of opportunities to speed up drug development and reduce the associated risks and costs. While ... [more ▼]

Virtual screening, the search for bioactive compounds via computational methods, provides a wide range of opportunities to speed up drug development and reduce the associated risks and costs. While virtual screening is already a standard practice in pharmaceutical companies, its applications in preclinical academic research still remain under-exploited, in spite of an increasing availability of dedicated free databases and software tools. In this survey, an overview of recent developments in this field is presented, focusing on free software and data repositories for screening as alternatives to their commercial counterparts, and outlining how available resources can be interlinked into a comprehensive virtual screening pipeline using typical academic computing facilities. Finally, to facilitate the set-up of corresponding pipelines, a downloadable software system is provided, using platform virtualization to integrate pre-installed screening tools and scripts for reproducible application across different operating systems. [less ▲]

Building Blocks for the Development of an International Framework for the Governance of Space Resources Activities: A Commentary

Book published by Eleven - 1st (2020)

The publication is a result of the work of an international interdisciplinary working group which formulated principles of an international regime which can govern the space resources activities. It has ... [more ▼]

The publication is a result of the work of an international interdisciplinary working group which formulated principles of an international regime which can govern the space resources activities. It has been submitted to the UN Copuos. [less ▲]

Building blocks of self-sustained activity in a simple deterministic model of excitable neural networks.

in Frontiers in computational neuroscience (2012), 6

Understanding the interplay of topology and dynamics of excitable neural networks is one of the major challenges in computational neuroscience. Here we employ a simple deterministic excitable model to ... [more ▼]

Understanding the interplay of topology and dynamics of excitable neural networks is one of the major challenges in computational neuroscience. Here we employ a simple deterministic excitable model to explore how network-wide activation patterns are shaped by network architecture. Our observables are co-activation patterns, together with the average activity of the network and the periodicities in the excitation density. Our main results are: (1) the dependence of the correlation between the adjacency matrix and the instantaneous (zero time delay) co-activation matrix on global network features (clustering, modularity, scale-free degree distribution), (2) a correlation between the average activity and the amount of small cycles in the graph, and (3) a microscopic understanding of the contributions by 3-node and 4-node cycles to sustained activity. [less ▲]

Building Bridges or a Bridge Too Far? The "Macedonia" Name Agreement, and the Past, Present and Future of Greek Interstate Relations.

Presentation (2019, April 29)

The “Macedonia” name issue has been a constant point of contention between Greece and the newly re-named Republic of North Macedonia, since the breakup of Yugoslavia. With the origins of the dispute ... [more ▼]

The “Macedonia” name issue has been a constant point of contention between Greece and the newly re-named Republic of North Macedonia, since the breakup of Yugoslavia. With the origins of the dispute stretching back to the Second World War, the “Prespa Agreement,” signed between the two Balkan neighbors in June 2018 (coming into force in February 2019) is hoped to be a new beginning in interstate relations in the Balkans. Through Prime Ministers Tspiras and Zeav have adopted warm facades in front of the cameras, significant opposition to the agreement domestically and abroad highlights the transnational / international legacy and implications of this dispute. In this lecture, Dr, Spero Paravantes will examine the history of the dispute over the name “Macedonia.” He will then explain the Prespa Agreement, some of the controversies surrounding it, and he will discuss the role played in the dispute (and in the agreement) by foreign diplomats. He will concluded with an assessment of the domestic and international implications of the Former Yugoslav Republic of Macedonia (FYROM), becoming the Republic of North Macedonia. (Link: http://events.berkeley.edu/index.php/calendar/sn/ies.html?event_ID=124978&date=2019-04-29&filter=Target/Open%20To%20Audiences&filtersel=) (Summary: https://ies.berkeley.edu/sites/default/files/shared/docs/newsletters/IES%20Spring%202019%20News%20final.pdf) [less ▲]

Building bridges or taking the ferry: Pidgins, Creoles and Language Acquisition in a Multilingual Setting

Presentation (2004, May 21)

Building Capacity for Comparative and International Social Sciences: Inter-organizational Collaboration and EU Research Funding & Degree Programs

Scientific Conference (2019)

In this essay, I present global mega-trends in higher education and science (expansion, competition, collaboration), discuss regional shifts in scientific publication globally since 1900 and systematic ... [more ▼]

In this essay, I present global mega-trends in higher education and science (expansion, competition, collaboration), discuss regional shifts in scientific publication globally since 1900 and systematic attempts to build capacity for knowledge production, especially in research universities. Pure exponential growth in the publication of research articles is matched by rising international, interorganizational, and transdisciplinary collaboration. The implications of these patterns, especially for international and comparative social sciences, are then briefly delineated on the basis of the case of EU research funding (Framework Programmes) and joint degree programs (Erasmus Mundus) that promote sustainable collaborations across borders in Europe. [less ▲]

Building Information Modeling (BIM) in Eco-Construction and Sustainable Development

Poster (2018, September 26)