System Evaluation of Optimal Downlink Beamforming with Congestion Control in Wireless Communication

in IEEE Transactions on Wireless Communications (2006), 5(4), 743751

A system for the design and development of vision-based multi-robot quadrotor swarms

in 2014 International Conference on Unmanned Aircraft Systems (ICUAS) (2014, May)

This paper presents a cost-effective framework for the prototyping of vision-based quadrotor multi-robot systems, which core characteristics are: modularity, compatibility with different platforms and ... [more ▼]

This paper presents a cost-effective framework for the prototyping of vision-based quadrotor multi-robot systems, which core characteristics are: modularity, compatibility with different platforms and being flight-proven. The framework is fully operative, which is shown in the paper through simulations and real flight tests of up to 5 drones, and was demonstrated with the participation in an international micro-aerial vehicles competition3 where it was awarded with the First Prize in the Indoors Autonomy Challenge. The motivation of this framework is to allow the developers to focus on their own research by decoupling the development of dependent modules, leading to a more cost-effective progress in the project. The basic instance of the framework that we propose, which is flight-proven with the cost-efficient and reliable platform Parrot AR Drone 2.0 and is open-source, includes several modules that can be reused and modified, such as: a basic sequential mission planner, a basic 2D trajectory planner, an odometry state estimator, localization and mapping modules which obtain absolute position measurements using visual markers, a trajectory controller and a visualization module. [less ▲]

System Modelling and Design Aspects of Next Generation High Throughput Satellites

in IEEE Communications Letters (2021), 69

As compared to terrestrial systems, the design of Satellite Communication (SatCom) systems require a different approach due to differences in terms of wave propagation, operating frequency, antenna ... [more ▼]

As compared to terrestrial systems, the design of Satellite Communication (SatCom) systems require a different approach due to differences in terms of wave propagation, operating frequency, antenna structures, interfering sources, limitations of onboard processing, power limitations and transceiver impairments. In this regard, this letter aims to identify and discuss important modeling and design aspects of the next generation High Throughput Satellite (HTS) systems. First, communication models of HTSs including the ones for multibeam and multicarrier satellites, multiple antenna techniques, and for SatCom payloads and antennas are highlighted and discussed. Subsequently, various design aspects of SatCom transceivers including impairments related to the transceiver, payload and channel, and traffic-based coverage adaptation are presented. Finally, some open topics for the design of next generation HTSs are identified and discussed. [less ▲]

System reliability and weighted lattice polynomials

in Probability in the Engineering and Informational Sciences (2008), 22(3), 373-388

The lifetime of a system of connected units under some natural assumptions can be represented as a random variable Y defined as a weighted lattice polynomial of random lifetimes of its components. As such ... [more ▼]

The lifetime of a system of connected units under some natural assumptions can be represented as a random variable Y defined as a weighted lattice polynomial of random lifetimes of its components. As such, the concept of a random variable Y defined by a weighted lattice polynomial of (lattice-valued) random variables is considered in general and in some special cases. The central object of interest is the cumulative distribution function of Y. In particular, numerous results are obtained for lattice polynomials and weighted lattice polynomials in case of independent arguments and in general. For the general case, the technique consists in considering the joint probability generating function of "indicator" variables. A connection is studied between Y and order statistics of the set of arguments. [less ▲]

Systematic Analysis and Modelling of Profit Maximization on Carsharing

in Journal of Advanced Transportation (2022)

Systematic analysis of global and local control policies

in Periodica Polytechnica Transportation Engineering (2015)

Systematic approaches to mouse mutagenesis.

in Current Opinion in Genetics and Development (2001), 11(3), 268-73

A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin ... [more ▼]

A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin systematic and comprehensive approaches to mammalian gene function studies. Recently, a number of centres have completed large-scale ENU mutagenesis programmes that employ a phenotype-driven approach to the generation of mouse mutants. The use of ENU mutagenesis represents a powerful and efficient approach to mammalian gene-function studies, but many parallel developments are needed in downstream technologies to properly harness the new enlarged mouse-mutant resources that are being created. [less ▲]

Systematic assessment of local & global control policies: A methodological perspective

in Proceedings of the MT-ITS Conference (2015, June)

Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease

in Microbiome (2019)

Background The human gut microbiome performs important functions in human health and disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of primary bile acids and their ... [more ▼]

Background The human gut microbiome performs important functions in human health and disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of primary bile acids and their subsequent deconjugation and transformation by the gut microbiome. To understand these system-level host-microbe interactions, a mechanistic, multi-scale computational systems biology approach that integrates the different types of omic data is needed. Here, we use a systematic workflow to computationally model bile acid metabolism in gut microbes and microbial communities. Results Therefore, we first performed a comparative genomic analysis of bile acid deconjugation and biotransformation pathways in 693 human gut microbial genomes and expanded 232 curated genome-scale microbial metabolic reconstructions with the corresponding reactions (available at https://vmh.life). We then predicted the bile acid biotransformation potential of each microbe and in combination with other microbes. We found that each microbe could produce maximally six of the 13 secondary bile acids in silico, while microbial pairs could produce up to 12 bile acids, suggesting bile acid biotransformation being a microbial community task. To investigate the metabolic potential of a given microbiome, publicly available metagenomics data from healthy Western individuals, as well as inflammatory bowel disease patients and healthy controls, were mapped onto the genomes of the reconstructed strains. We constructed for each individual a large-scale personalized microbial community model that takes into account strain-level abundances. Using flux balance analysis, we found considerable variation in the potential to deconjugate and transform primary bile acids between the gut microbiomes of healthy individuals. Moreover, the microbiomes of pediatric inflammatory bowel disease patients were significantly depleted in their bile acid production potential compared with that of controls. The contributions of each strain to overall bile acid production potential across individuals were found to be distinct between inflammatory bowel disease patients and controls. Finally, bottlenecks limiting secondary bile acid production potential were identified in each microbiome model. Conclusions This large-scale modeling approach provides a novel way of analyzing metagenomics data to accelerate our understanding of the metabolic interactions between the host and gut microbiomes in health and diseases states. Our models and tools are freely available to the scientific community. [less ▲]

A systematic comparison of two new releases of exome sequencing products: the aim of use determines the choice of product.

in Biological chemistry (2016), 397(8), 791-801

We received early access to the newest releases of exome sequencing products, namely Agilent SureSelect v6 (Agilent, Santa Clara, CA, USA) and NimbleGen MedExome (Roche NimbleGen, Basel, Switzerland), and ... [more ▼]

We received early access to the newest releases of exome sequencing products, namely Agilent SureSelect v6 (Agilent, Santa Clara, CA, USA) and NimbleGen MedExome (Roche NimbleGen, Basel, Switzerland), and we conducted whole exome sequencing (WES) of several DNA samples with each of these products in order to assess their performance. Here, we provide a detailed evaluation of the original, normalized (with respect to the different target sizes), and trimmed data sets and compare them in terms of the amount of duplicates, the reads on target, and the enrichment evenness. In addition to these general statistics, we performed a detailed analysis of the frequently mutated and newly described genes found in 'The Deciphering Developmental Disorders Study' published very recently (Fitzgerald, T.W., Gerety, S.S., Jones, W.D., van Kogelenberg, M., King, D.A., McRae, J., Morley, K.I., Parthiban, V., Al-Turki, S., Ambridge, K., et al. (2015). Large-scale discovery of novel genetic causes of developmental disorders. Nature 519, 223-228.). In our comparison, the Agilent v6 exome performs better than the NimbleGen's MedExome both in terms of efficiency and evenness of coverage distribution. With its larger target size, it is also more comprehensive, and therefore the better choice in research projects that aim to identify novel disease-associated genes. In contrast, if the exomes are mainly used in a diagnostic setting, we see advantages for the new NimbleGen MedExome. We find a superior coverage here in those genes of high clinical relevance that likely allows for a better detection of relevant, disease-causing mutations. [less ▲]