Synthesis of K2Se solar cell dopant in liquid NH3 by solvated electron transfer to elemental selenium

in Electrochemistry Communications (2018), 93

Synthesis of trigonal selenium nanorods by electrodeposition from an ionic liquid at high temperature

in Electrochemistry Communications (2011), 13(8), 865-868

Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers

in Journal of Controlled Release (2016), 243

The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We ... [more ▼]

The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We investigated different poly(methacrylic acid)-g-poly(ethyleneglycol methacrylate) polymers as in situ coating agents for magnetite nanocrystallites. The obtained magnetic nano-assemblies were in turn thoroughly characterized for their structural, colloidal and physicochemical properties (drug loading capacity/release, magnetic field triggered drug release, cell uptake and localization) in order to select the best performing system. With the focus on in vivo validation of such magnetic drug delivery systems for first time, we selected cisplatin as the drug, since it is a potent anticancer agent which exhibits serious side effects due to lack of selectivity. In addition, cisplatin would offer facile determination of the metal content in the animal tissues for biodistribution studies. Alongside post-mortem Pt determination in the tissues, the biodistribution of the drug nanocarriers was also monitored in real time with PET-CT (positron emission tomography/computed tomography) with and without the presence of magnetic field gradients; using a novel chelator-free method, the nanoparticles were radiolabeled with 68Ga without having to alter their structure with chemical modifications for conjugation of radiochelators. The ability to be radiolabeled in such a straightforward but very robust way, along with their measured high MRI response, renders them attractive for dual imaging, which is an important functionality for translational investigations. Their anticancer properties were evaluated in vitro and in vivo, in a cisplatin resistant HT-29 human colon adenocarcinoma model, with and without the presence of magnetic field gradients. Enhanced anticancer efficacy and reduced toxicity was recorded for the cisplatin-loaded nanocarriers in comparison to the free cisplatin, particularly when a magnetic field gradient was applied at the tumor site. Post mortem and real-time tissue distribution studies did not reveal increased cisplatin concentration in the tumor site, suggesting that the enhanced anticancer efficacy of the cisplatin-loaded nanocarriers is driven by mechanisms other than increased cisplatin accumulation in the tumors. © 2016 Elsevier B.V. [less ▲]

Synthesis, theoretical and experimental characterisation of thin film Cu2Sn1-xGexS3 ternary alloys (x = 0 to 1): Homogeneous intermixing of Sn and Ge

in Acta Materialia (2018), 151

Cu2Sn1-xGexS3 is a p-type semiconductor alloy currently investigated for use as an absorber layer in thin film solar cells. The aim of this study is to investigate the properties of this alloy in thin ... [more ▼]

Cu2Sn1-xGexS3 is a p-type semiconductor alloy currently investigated for use as an absorber layer in thin film solar cells. The aim of this study is to investigate the properties of this alloy in thin film form in order to establish relationships between group IV composition and structural, vibrational and opto-electronic properties. Seven single phase Cu2Sn1-xGexS3 films are prepared from x ¼ 0 to 1, showing a uniform distribution of Ge and Sn laterally and in depth. The films all show a monoclinic crystal structure. The lattice parameters are extracted using Le Bail refinement and show a linear decrease with increasing Ge content. Using density-functional theory with hybrid functionals, we calculate the Raman active phonon frequencies of Cu2SnS3 and Cu2GeS3. For the alloyed compounds, we use a virtual atom approximation. The shift of the main Raman peak from x ¼ 0 to x ¼ 1 can be explained as being half due to the change in atomic masses and half being due to the different bond strength. The bandgaps of the alloys are extracted from photoluminescence measurements and increase linearly from about 0.90 to 1.56 eV with increasing Ge. The net acceptor density of all films is around 1018 cm 3. These analyses have established that the alloy forms a solid solution over the entire composition range meaning that intentional band gap grading should be possible for future absorber layers. The linear variation of the unit cell parameters and the band gap with group IV content allows composition determination by scattering or optical measurements. Further research is required to reduce the doping density by two orders of magnitude in order to improve the current collection within a solar cell device structure. [less ▲]

Synthetic Data Generation for Statistical Testing

in 32nd IEEE/ACM International Conference on Automated Software Engineering (ASE'17) (2017)

Usage-based statistical testing employs knowledge about the actual or anticipated usage profile of the system under test for estimating system reliability. For many systems, usage-based statistical ... [more ▼]

Usage-based statistical testing employs knowledge about the actual or anticipated usage profile of the system under test for estimating system reliability. For many systems, usage-based statistical testing involves generating synthetic test data. Such data must possess the same statistical characteristics as the actual data that the system will process during operation. Synthetic test data must further satisfy any logical validity constraints that the actual data is subject to. Targeting data-intensive systems, we propose an approach for generating synthetic test data that is both statistically representative and logically valid. The approach works by first generating a data sample that meets the desired statistical characteristics, without taking into account the logical constraints. Subsequently, the approach tweaks the generated sample to fix any logical constraint violations. The tweaking process is iterative and continuously guided toward achieving the desired statistical characteristics. We report on a realistic evaluation of the approach, where we generate a synthetic population of citizens' records for testing a public administration IT system. Results suggest that our approach is scalable and capable o [less ▲]

SYSGENET: a meeting report from a new European network for systems genetics

in Mammalian Genome (2010), 21(7-8), 331-6

The first scientific meeting of the newly established European SYSGENET network took place at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, April 7-9, 2010. About 50 researchers ... [more ▼]

The first scientific meeting of the newly established European SYSGENET network took place at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, April 7-9, 2010. About 50 researchers working in the field of systems genetics using mouse genetic reference populations (GRP) participated in the meeting and exchanged their results, phenotyping approaches, and data analysis tools for studying systems genetics. In addition, the future of GRP resources and phenotyping in Europe was discussed. [less ▲]

A SysML-based Integration Framework for the Engineering of Mechatronic Systems

in IEEE/ASME International Conference on Mechatronics and Embedded Systems and Applications (MESA), Qingdao, China, 2010 (2010)

The engineering discipline mechatronics is one of the main innovation leader in industry nowadays. With the need for an optimal synergetic integration of the involved disciplines, the engineering process ... [more ▼]

The engineering discipline mechatronics is one of the main innovation leader in industry nowadays. With the need for an optimal synergetic integration of the involved disciplines, the engineering process of mechatronic systems is faced with an increasing complexity and the interdisciplinary nature of these systems. New methods and techniques have to be developed to deal with these challenges. This document presents an approach of a SysML-based integration framework that shall deal with the complexity and bring the different disciplines together for a better cooperation and collaboration. Therefore, SysML shall be used for the overall interdisciplinary system design and simultaniously act as a link between the heterogenous model data of the discipline specific tools. [less ▲]

„Das System aller philosophischen Erkenntnis ist nun Philosophie“. Kants Kritik und Neubestimmung der Metaphysik

in Plevrakis, Ermylos (Ed.) Grundlegung des Absoluten? (2019)

While the Kantian epistemology was discovered for analytical philosophy by P. F. Strawson in the middle of the last century and has inspired this philosophical discourse since then, the metaphysical ... [more ▼]

While the Kantian epistemology was discovered for analytical philosophy by P. F. Strawson in the middle of the last century and has inspired this philosophical discourse since then, the metaphysical features of Kantian philosophy have mostly been ignored in recent times. What is overlooked is the fact that Kant's epistemological foundation of philosophy through the Critique of Pure Reason aims precisely to establish metaphysics as a science. In order to evaluate the possibility of scientific metaphysics, the Critique of Pure Reason examines the principles of synthetic judgments a priori. She comes to the result that the metaphysical questioning about the absolute is laid out in the finite discursive reason of man as such, but cannot be satisfied with the means of speculative use of reason, but refers to the practical use of reason. [less ▲]

SYSTEM BIOLOGY APPROACH TOWARDS THE ONCOGENIC SIGNALLING IN GASTROINTESTINAL STROMAL TUMOURS

Doctoral thesis (2017)

System Design and Implementation Decisions for ParaMoise Organizational Model

in Proceedings of the 2013 Federated Conference on Computer Science and Information Systems (2013, September)