Systematic trading behaviour and its informational effect: evidence from the OMXHRose, Annica ![]() in Applied Financial Economics (2014), 24(22), 1421-1427 By using signed small trade turnover (SSTT) as a proxy of investors’ systematic trading behaviour and permanent price effect (PPE) as a proxy for informed trading, this article investigates the short-term ... [more ▼] By using signed small trade turnover (SSTT) as a proxy of investors’ systematic trading behaviour and permanent price effect (PPE) as a proxy for informed trading, this article investigates the short-term outperformance of high SSTT stocks for categories of investors on the NASDAQ OMX Helsinki (OMXH) and whether the outperformance is best understood in the context of investor trading behaviour or informed trading. This study finds that the trading of high SSTT stocks is associated with a lower PPE than the trading of low SSTT stocks, which implies that the trading of high SSTT stocks is less informed than the trading of low SSTT stocks, and that the short-term outperformance of high SSTT stocks relative to low SSTT stocks is best explained within the behavioural finance framework, that is, by investors’ bias towards popular stocks proxied by SSTT, and not within the rational framework, that is, by informed trading proxied by the PPE. These findings are economically and statistically significant for all types of investors. [less ▲] Detailed reference viewed: 84 (1 UL) Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer typesKirchmeyer, Mélanie ; Servais, Florence ; Ginolhac, Aurélien et alin Journal of Molecular Biology (2020) Cytokines orchestrate responses to pathogens and in inflammatory processes but they also play an important role in cancer by shaping the expression levels of cytokine response genes. Here, we conducted a ... [more ▼] Cytokines orchestrate responses to pathogens and in inflammatory processes but they also play an important role in cancer by shaping the expression levels of cytokine response genes. Here, we conducted a large profiling study comparing miRNome and mRNA transcriptome data generated following different cytokine stimulations. Transcriptomic responses to STAT1- (IFN, IL-27) and STAT3-activating cytokines (IL6, OSM) were systematically compared in nine cancerous and nonneoplastic cell lines of different tissue origins (skin, liver and colon). The largest variation in our datasets was seen between cell lines of the three different tissues rather than stimuli. Notably, the variability in miRNome datasets was a lot more pronounced than in mRNA data. Our data also revealed that cells of skin, liver and colon tissues respond very differently to cytokines and that the cell signaling networks activated or silenced in response to STAT1- or STAT3- activating cytokines are specific to the tissue and the type of cytokine. However, globally, STAT1-activating cytokines had stronger effects than STAT3-inducing cytokines with most significant responses in liver cells, showing more genes up-regulated and with higher fold change. A more detailed analysis of gene regulations upon cytokine stimulation in these cells provided insights into STAT1- versus STAT3-driven processes in hepatocarcinogenesis. Finally, independent component analysis revealed interconnected transcriptional networks distinct between cancer cells and their healthy counterparts. [less ▲] Detailed reference viewed: 180 (13 UL) The systematic variation of task characteristics facilitates the understanding of task difficulty: A cognitive diagnostic modeling approach to complex problem solvingGreiff, Samuel ; Krkovic, Katarina ; in Psychological Test and Assessment Modeling (2014), 56(1), 83-103 Since the 1960ies, when pioneering research on Item Response Theory (IRT) was published, considerable progress has been made with regard to the psychometrical quality of psychological assessment tools ... [more ▼] Since the 1960ies, when pioneering research on Item Response Theory (IRT) was published, considerable progress has been made with regard to the psychometrical quality of psychological assessment tools. One recent development building upon IRT is the introduction of Cognitive Diagnostic Modeling (CDM). The major goal of introducing CDM was to develop methods that allow for examining which cognitive processes are involved when a person is working on a specific assessment task. More precisely, CDM enables researchers to investigate whether assumed task characteristics drive item difficulty and, thus, person ability parameters. This may – at least according to the assumption inherent in CDM - allow conclusions about cognitive processes involved in assessment tasks. In this study, out of the numerous CDMs available the Least Square Distance Method (LSDM; Dimitrov, 2012) was applied to investigate psychometrical qualities of an assessment instrument measuring Complex Problem Solving (CPS) skills. For the purpose of the study, two task characteristics essential for mastering CPS tasks were identified ex-ante – degree of connectivity and presence of indirect effects by adding eigendynamics to the task. The study examined whether and how the two hypothesized task characteristics drive item difficulty of two CPS dimensions, knowledge acquisition and knowledge application. The sample consisted of 490 German high school students, who completed the computer-based CPS assessment instrument MicroDYN. The two task characteristics in MicroDYN items were varied systematically. Results obtained in LSDM indicated that the two hypothesized task characteristics, degree of connectivity and introducing indirect effects, drove item difficulty only for knowledge acquisition. Hence, other task characteristics that may determine item difficulty of knowledge application need to be investigated in future studies in order to provide a sound measurement of CPS. [less ▲] Detailed reference viewed: 491 (33 UL) Systematische Erforschung komplexer Problemlösefähigkeit anhand minimal komplexer SystemeGreiff, Samuel ; in Zeitschrift für Pädagogik. Beiheft (2010), 56 Detailed reference viewed: 100 (12 UL) Systematization of threats and requirements for private messaging with untrusted servers. The case of E-mailing and instant messagingSymeonidis, Iraklis ; Lenzini, Gabriele ![]() in International Conference on Information Systems Security and Privacy, Malta 25-27 February 2020 (2020, February) Modern email and instant messaging applications often offer private communications. In doing so, they share common concerns about how security and privacy can be compromised, how they should face similar ... [more ▼] Modern email and instant messaging applications often offer private communications. In doing so, they share common concerns about how security and privacy can be compromised, how they should face similar threats, and how to comply with comparable system requirements. Assuming a scenario where servers may not be trusted, we review and analyze a list of threats specifically against message delivering, archiving, and contact synchronization. We also describe a list of requirements intended for whom undertakes the task of implementing secure and private messaging. The cryptographic solutions available to mitigate the threats and to comply with the requirements may differ, as the two applications are built on different assumptions and technologies. [less ▲] Detailed reference viewed: 153 (14 UL) Systembasierte Analyse von Wirkstoffresistenzen bei MelanomLucarelli, Philippe ; De Landtsheer, Sébastien ; Sauter, Thomas ![]() E-print/Working paper (2017) Detailed reference viewed: 76 (5 UL) Le système juridictionnel de l’Union comme garantie de l’Etat de droit dans la jurisprudence récente de la CJUEZinonos, Panagiotis ![]() in Revue du Droit de l'Union Européenne (2019), (4), 153-168 La jurisprudence récente de la Cour de justice suggère que la fonction du système juridictionnel de l’Union, composé des juridictions nationales et européennes stricto sensu, n’est pas seulement de ... [more ▼] La jurisprudence récente de la Cour de justice suggère que la fonction du système juridictionnel de l’Union, composé des juridictions nationales et européennes stricto sensu, n’est pas seulement de garantir le contenu matériel de l’Etat de droit. Les principes régissant ce système et ses mécanismes constituent en effet autant de composantes du contenu de l’Etat de droit et font du système juridictionnel une garantie à part entière de cette valeur fondatrice de l’Union. D’un point de vue procédural, la fonction nouvelle du système juridictionnel s’exprime par les obligations incombant aux Etats membres et par l’office européen du juge national, dont la pratique a transformé, dans un esprit de loyauté juridictionnelle et de volontarisme, les mécanismes du renvoi préjudiciel et du mandat d’arrêt européen en garanties systémiques de l’Etat de droit. La présente contribution propose une modélisation nouvelle de l’Union qui permet de visualiser le rapprochement du contenu systémique de la protection juridictionnelle et du principe européen de légalité mais aussi la suprématie du principe de loyauté qui non seulement affecte le principe de légalité mais fait aussi émerger des principes fonctionnels dérivés tels que la primauté et la confiance mutuelle. [less ▲] Detailed reference viewed: 84 (3 UL) Le système juridique français à l'ère de la contractualisationHiez, David ; in La contractualisation de la production normative (2008) Detailed reference viewed: 150 (1 UL)![]() Un système plurilingue peut-il être efficace?Martin, Romain ; Houssemand, Claude ![]() in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003, September), 15(16), 157-164 Detailed reference viewed: 89 (4 UL) Le système scolaire luxembourgeois : aperçu et tendancesLenz, Thomas ; Heinz, Andreas ![]() in LUCET; SCRIPT (Eds.) Rapport national sur l'éducation au Luxembourg 2018 (2018) Cet article donne un aperçu des principaux faits et chiffres du système scolaire luxembourgeois et présente les développements réalisés au cours des dernières années. L’accent est mis en particulier sur ... [more ▼] Cet article donne un aperçu des principaux faits et chiffres du système scolaire luxembourgeois et présente les développements réalisés au cours des dernières années. L’accent est mis en particulier sur la transition de l’enseignement fondamental à l’enseignement secondaire. À cet égard, d’importantes différences sont en partie observées en fonction du sexe, des nationalités et entre différentes communes du Luxembourg. [less ▲] Detailed reference viewed: 81 (1 UL)![]() Le système scolaire luxembourgeois: Un système scolaire scolaire peu efficace malgré ou à cause de son caractère multilingue?Portante, Dominique ; Martin, Romain ![]() in Cahiers du Service de Pédagogie Expérimentale (SPE) (2003), 15/16(4), 516-532 Detailed reference viewed: 132 (12 UL) Les systèmes automatisés vont-ils redéfinir la nature du combat terrestre ?Fouillet, Thibault ![]() Report (2020) L’analyse des doctrines des grandes puissances étrangères confirme une tendance à la massification des systèmes automatisés (SA) et une progressive autonomisation de leurs capacités aussi bien létales que ... [more ▼] L’analyse des doctrines des grandes puissances étrangères confirme une tendance à la massification des systèmes automatisés (SA) et une progressive autonomisation de leurs capacités aussi bien létales que non létales. A cet égard, les principales puissances, USA, Chine, Russie, Israël, préparent le déploiement de Systèmes d’Armes Autonomes Létaux (SALA) sous supervision humaine, à la différence d’autres Etats comme la France et le Canada qui refusent de déshumaniser le combat. Ce phénomène appelé à se développer du fait des progrès techniques et informatiques, pourrait connaître une accélération avec la maîtrise de l’intelligence artificielle et les progrès de miniaturisation. Cette prolifération pouvant se faire de manière discrète puisque la composition des SALA n’implique pas, pour une majeure partie, de composants soumis à un contrôle de la communauté internationale. Cette menace impacte notablement la plupart des huit facteurs de supériorité opérationnelle retenus par l’armée de Terre, sensibles à l’apparition de nouveaux moyens automatiques et autonomes, et doit conduire les forces à évoluer en termes capacitaires (Doctrine, Organisation, R-H, Entrainement, Soutien, Equipement). Il s’agit ainsi, de moderniser progressivement les forces terrestres françaises par l’introduction de systèmes d’armes automatiques et adaptés à la lutte contre les SALA en assurant leur compatibilité avec les moyens existants, en particulier le système infovalorisé SCORPION. Pour garantir l’efficacité des forces aéroterrestres, il faut savoir tirer le meilleur parti des modules et plateformes automatiques, tout en préservant la place centrale de l’Homme. Cet impératif nécessitera d’accorder une attention particulière, au rythme d’introduction des systèmes autonomes dans les forces, au type de missions qui leurs sont confiées et à la relation Homme/Machine, par le développement de systèmes préservant la cohérence de l’action malgré une automatisation progressive de leurs fonctions. Toutefois, il ne faudrait pas que le respect de principes éthiques empêche d’anticiper les risques constitués par le déploiement de SALA par l’adversaire. Dans cette perspective, la protection de la force avec des moyens adaptés constitue un autre impératif, tout aussi important. En effet, l’introduction de systèmes létaux autonomes en masse par un adversaire pourrait faire notablement évoluer la nature du combat. Une force ennemie ainsi dotée de très nombreux SALA, agissant au sol et près du sol, pourrait tirer parti au cours d’un engagement d’un effet de saturation et de relative insensibilité aux pertes matérielles en privilégiant la brutalité à la manœuvre. [less ▲] Detailed reference viewed: 29 (0 UL) Systèmes de numération en base rationnelleLeroy, Julien ![]() Presentation (2008, October) Detailed reference viewed: 34 (0 UL) A systemic approach to interpersonal relationships and activities among French teleworkers; Pignault, Anne ![]() in New Technology, Work and Employment (2014), 29(2), 177-192 Within a systemic and interactional approach, this study seeks to understand how French teleworkers (re)organise their relationships with others as well as their activities. Lexical analysis of interviews ... [more ▼] Within a systemic and interactional approach, this study seeks to understand how French teleworkers (re)organise their relationships with others as well as their activities. Lexical analysis of interviews with 24 telecommuters (nomadic, alternating and working at home full-time) confirms and complements the results in the literature in this field. On one hand, the findings confirmed a decline in the quality of professional relationships due to their being mediated through technology. On the other hand, there was a distinction between the ways in which different types of teleworkers ascribed meaning and adapted their activities and business, family and social relationships. [less ▲] Detailed reference viewed: 138 (4 UL) Systemic network analysis identifies XIAP and IkappaBalpha as potential drug targets in TRAIL resistant BRAF mutated melanoma.; Lucarelli, Philippe ; et alin NPJ systems biology and applications (2018), 4 Metastatic melanoma remains a life-threatening disease because most tumors develop resistance to targeted kinase inhibitors thereby regaining tumorigenic capacity. We show the 2nd generation hexavalent ... [more ▼] Metastatic melanoma remains a life-threatening disease because most tumors develop resistance to targeted kinase inhibitors thereby regaining tumorigenic capacity. We show the 2nd generation hexavalent TRAIL receptor-targeted agonist IZI1551 to induce pronounced apoptotic cell death in mutBRAF melanoma cells. Aiming to identify molecular changes that may confer IZI1551 resistance we combined Dynamic Bayesian Network modelling with a sophisticated regularization strategy resulting in sparse and context-sensitive networks and show the performance of this strategy in the detection of cell line-specific deregulations of a signalling network. Comparing IZI1551-sensitive to IZI1551-resistant melanoma cells the model accurately and correctly predicted activation of NFkappaB in concert with upregulation of the anti-apoptotic protein XIAP as the key mediator of IZI1551 resistance. Thus, the incorporation of multiple regularization functions in logical network optimization may provide a promising avenue to assess the effects of drug combinations and to identify responders to selected combination therapies. [less ▲] Detailed reference viewed: 64 (3 UL) Systemic operational risk − Spillover effects of large operational losses in the European banking industryKaspereit, Thomas ; Lopatta, Kerstin ; et alin Journal of Risk Finance (2017), 18(3), Detailed reference viewed: 129 (17 UL) A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.; ; et al in Nucleic Acids Research (2013), 41(6), 3699-712 Stem cell fate decisions are controlled by a molecular network in which transcription factors and miRNAs are of key importance. To systemically investigate their impact on neural stem cell (NSC ... [more ▼] Stem cell fate decisions are controlled by a molecular network in which transcription factors and miRNAs are of key importance. To systemically investigate their impact on neural stem cell (NSC) maintenance and neuronal commitment, we performed a high-throughput mRNA and miRNA profiling and isolated functional interaction networks of involved mechanisms. Thereby, we identified an E2F1-miRNA feedback loop as important regulator of NSC fate decisions. Although E2F1 supports NSC proliferation and represses transcription of miRNAs from the miR-17 approximately 92 and miR-106a approximately 363 clusters, these miRNAs are transiently up-regulated at early stages of neuronal differentiation. In these early committed cells, increased miRNAs expression levels directly repress E2F1 mRNA levels and inhibit cellular proliferation. In mice, we demonstrated that these miRNAs are expressed in the neurogenic areas and that E2F1 inhibition represses NSC proliferation. The here presented data suggest a novel interaction mechanism between E2F1 and miR-17 approximately 92 / miR-106a approximately 363 miRNAs in controlling NSC proliferation and neuronal differentiation. [less ▲] Detailed reference viewed: 241 (4 UL)![]() Systemisches und räumliches Denken in der geographischen Bildung. Erste Ergebnisse zur Überprüfung eines Modells der Geographischen Systemkompetenz; ; Wüstenberg, Sascha et alScientific Conference (2011, April 06) Detailed reference viewed: 104 (1 UL) Systemisches und räumliches Denken in der geographischen Bildung. Erste Ergebnisse zur Überprüfung eines Modells der Geographischen Systemkompetenz; ; Wüstenberg, Sascha et alin Hüttermann, A.; Kirchner, P.; Schuler, S. (Eds.) et al Räumliche Orientierung: Räumliche Orientierung, Karten und Geoinformation im Unterricht (2012) Detailed reference viewed: 140 (2 UL) Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.; ; et al in Cell systems (2018), 6(6), 722-7336 The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 ... [more ▼] The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or high-fat diet and integrated these data with complementary multi-omics datasets. We identified several lipid species and lipid clusters with specific phenotypic and molecular signatures and, in particular, cardiolipin species with signatures of healthy and fatty liver. Genetic analyses revealed quantitative trait loci for 68% of the lipids (lQTL). By multi-layered omics analyses, we show the reliability of lQTLs to uncover candidate genes that can regulate the levels of lipid species. Additionally, we identified lQTLs that mapped to genes associated with abnormal lipid metabolism in human GWASs. This work provides a foundation and resource for understanding the genetic regulation and physiological significance of lipid species. [less ▲] Detailed reference viewed: 33 (0 UL) |
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