Psychosocial factors mediating the relationship between childhood emotional trauma and Internet gaming disorder: A pilot study

in European Journal of Psychotraumatology (2019), 10

gaming disorder (IGD) has been related to a wide range of detrimental psychological and health consequences. The purpose of the present pilot study was to test the direct and indirect relationships ... [more ▼]

gaming disorder (IGD) has been related to a wide range of detrimental psychological and health consequences. The purpose of the present pilot study was to test the direct and indirect relationships between IGD and emotional trauma, body image dissatisfaction, social anxiety, loneliness, depression, and self-esteem. A total of 242 online gamers completed a survey comprising a comprehensive battery of psychometric self-report scales concerning aforementioned variables. Results indicated that IGD was significantly correlated with all the variables except for body image dissatisfaction. Path analysis indicated an indirect relationship between childhood emotional trauma and IGD through depressive symptoms, while adjusting for gender, age, and number of hours gaming. The findings of the present study indicate that online gamers with a history of emotional abuse and/or neglect have higher levels of depressive symptoms, and that depressive symptoms are important risk factors of IGD. [less ▲]

Psychosomatic pathways to essential hypertension: the combined effect of anger and family history of cardiovascular disorders on cardiovascular reactivity

in Excerpta Medica International Congress Series1241 (2002)

Previous results from our laboratory suggest a combined effect of anger-suppression and family history of cardiovascular disorders in determining cardiovascular responses to mental stress. The present ... [more ▼]

Previous results from our laboratory suggest a combined effect of anger-suppression and family history of cardiovascular disorders in determining cardiovascular responses to mental stress. The present study was designed to determine the effect sizes in cardiovascular reactivity associated with biological risk, psychological risk and the combination of these risk factors using meta-analytical techniques. Results from three independent studies with almost identical experimental procedures provided the basis for the calculation of d, the difference between the means of two groups, divided by the pooled within-group standard deviation. Effect sizes were calculated for the comparison of high versus low biological hypertension risk, high versus low anger suppression, and high versus low combined risk. The results show the largest effect sizes for the comparison of high versus low combined risk. The effect sizes associated with the combination of risk factors were larger than the sum of the effect sizes associated with either factor alone. We conclude that the combination of biological and psychological risk factors in determining cardiovascular reactivity to mental stress is more than the sum of its parts. These findings are discussed in terms of a better understanding of the over-additive effects of multiple cardiovascular risk factors on cardiovascular morbidity and mortality. [less ▲]

Die Psychotechnik im Dienste der Berufsberatung - eine Erinnerung an die Verdienste von Nicolas Braunshausen

in Psychologische Rundschau: Ueberblick Uber die Fortschritte der Psychologie in Deutschland, Oesterreich, und der Schweiz (2021), 72(3), 220-221

Psychotropes et dépendance: profils de consommateurs et trajectoires de leur consommation

Book published by OFDT - Observatoire Français des Drogues et Toxicomanies (2001)

PTGL: a database for secondary structure-based protein topologies.

in Nucleic Acids Research (2010), 38(Database issue), 326-30

With growing amount of experimental data, the number of known protein structures also increases continuously. Classification of protein structures helps to understand relationships between protein ... [more ▼]

With growing amount of experimental data, the number of known protein structures also increases continuously. Classification of protein structures helps to understand relationships between protein structure and function. The main classification methods based on secondary structures are SCOP, CATH and TOPS, which all classify under different aspects, and therefore can lead to different results. We developed a mathematically unique representation of protein structure topologies at a higher abstraction level providing new aspects of classification and enabling for a fast search through the data. Protein Topology Graph Library (PTGL; http://ptgl.zib.de) aims at providing a database on protein secondary structure topologies, including search facilities, the visualization as intuitive topology diagrams as well as in the 3D structure, and additional information. Secondary structure-based protein topologies are represented uniquely as undirected labeled graphs in four different ways allowing for exploration under different aspects. The linear notations, and the 2D and 3D diagrams of each notation facilitate a deeper understanding of protein topologies. Several search functions for topologies and sub-topologies, BLAST search possibility, and links to SCOP, CATH and PDBsum support individual and large-scale investigation of protein structures. Currently, PTGL comprises topologies of 54,859 protein structures. Main structural patterns for common structural motifs like TIM-barrel or Jelly Roll are pre-implemented, and can easily be searched. [less ▲]

The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes

in BMC Medical Genetics (2011), 12(41),

BACKGROUND: The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be ... [more ▼]

BACKGROUND: The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type 1 diabetes. We investigated the association of the C1858T variant with residual beta-cell function (as assessed by stimulated C-peptide, proinsulin and insulin dose-adjusted HbA1c), glycemic control, daily insulin requirements, diabetic ketoacidosis (DKA) and diabetes-related autoantibodies (IA-2A, GADA, ICA, ZnT8Ab) in children during the first year after diagnosis of type 1 diabetes. METHODS: The C1858T variant was genotyped in an international cohort of children (n = 257 patients) with newly diagnosed type 1 diabetes during 12 months after onset. We investigated the association of this variant with liquid-meal stimulated beta-cell function (proinsulin and C-peptide) and antibody status 1, 6 and 12 months after onset. In addition HbA1c and daily insulin requirements were determined 1, 3, 6, 9 and 12 months after diagnosis. DKA was defined at disease onset. RESULTS: A repeated measurement model of all time points showed the stimulated proinsulin level is significantly higher (22%, p = 0.03) for the T allele carriers the first year after onset. We also found a significant positive association between proinsulin and IA levels (est.: 1.12, p = 0.002), which did not influence the association between PTPN22 and proinsulin (est.: 1.28, p = 0.03). CONCLUSIONS: The T allele of the C1858T variant is positively associated with proinsulin levels during the first 12 months in newly diagnosed type 1 diabetes children. [less ▲]

PubChemLite for Exposomics

Computer development (2020)

Public discourses and private memory processes in Luxembourgian steel worker families

in Boesen, Elisabeth; Lentz, Fabienne; Margue, Michel (Eds.) et al Peripheral memories: Public and private forms of experiencing and narrating the past (2012)

Public Good and Private Good Valuation for Waiting Time Reduction: A Laboratory Study

in Social Choice and Welfare (2012)

Public Hearings in Investor-State Treaty Arbitration: Revisiting the Principle

Doctoral thesis (2020)

This thesis examines the scope, role and contemporary application of the traditional principle of public hearings, with a particular focus on the specific dispute resolution system of investor-state ... [more ▼]

This thesis examines the scope, role and contemporary application of the traditional principle of public hearings, with a particular focus on the specific dispute resolution system of investor-state arbitration. Whereas there have been extensive discussions in recent years surrounding developments which aim to increase the procedural openness and transparency of this traditionally private dispute resolution system, the emergence of a distinct requirement of holding public hearings in such contexts has not yet been given much attention. This thesis seeks to provide a better understanding of public hearings in investment treaty arbitration. By going beyond the usual narrative of the legitimacy and policy objectives of transparency, a more systematic and comprehensive approach to the issue of public hearings in investor-state arbitration is adopted. In addressing existing gaps in the literature, this thesis contends that current developments related to the principle of public hearings should not be analysed as a phenomenon specific to investor-state arbitration, but should instead be analysed within the broader context of the analogous developments at both the domestic and international level. In conducting such an investigation, this thesis situates the debate surrounding public hearings in investment treaty arbitration within a broader legal landscape, encompassing both national and international courts and tribunals. By examining the evolution of public hearings, it is argued that a steady shift in the understanding of the principle of public hearings over time may be detected. Public hearings have gone from serving merely as a means of protecting the individual from the secrecy and arbitrariness of the state, to becoming a democratic tool which the public is entitled to use not only in order to monitor and evaluate the administration of justice, but also as a platform for facilitating further public debate. In other words, the thesis demonstrates a shift in the understanding of the principle of public hearings from being a mere right of an individual to be heard in an open court, to the (additional) right of the general public to have an insight into what goes on in the courtroom and the active duty of the courts to ensure that this right is respected. This latter aspect of the principle of public hearings is subject to comparative analysis which examines the normative and practical solutions adopted by national and international courts when applying the principle of public hearings. While detecting a divergent legal landscape when it comes to providing public access to hearings, this thesis reveals a general trend towards greater regulation of the ways in which the public may obtain such access. What is more, it shall be shown that, in an era of expanded media coverage of public hearings, the subsequent enlargement of the audiences for such hearings, and the possibility to instantly disseminate information about proceedings through various technologies creates new paths for procedural openness and new challenges for the courts. Based on the findings of this comparative analysis, the thesis argues that it is not only the principle of public hearings which has been renewed and transformed. In seeking to adapt to the principle, the procedures in which the principle of public hearings operates have also started to change. This comparative analysis then forms the basis upon which a critical analysis and in-depth assessment is provided within the context of public hearings in investor-state arbitration. From a more “dispute-oriented” perspective, the thesis looks into the considerations and challenges that ought to be taken into account by arbitral tribunals and parties when organising a public hearing. By not losing sight of the implications for the system as a whole, however, the thesis addresses the future impact that the introduction of public hearings into the system investor-state arbitration may have on that system and, notably, upon its procedures. The key finding here is that the increasing relevance of public hearings in investor-state arbitration constitutes merely one part of the overall evolution of the “public” dimension of the requirement of public hearings. When taking these developments together, the thesis concludes that the debate on what constitutes a truly public hearing has entered a new epoch, with new actors and new challenges. [less ▲]