Pain processing and coping with social stress in rats exposed to adverse early life events

Scientific Conference (2015)

Pain, Anxiety, and Cooperativeness in Children with Cerebral Palsy after Rhizotomy: Changes Throughout Rehabilitation

in Journal of Pediatric Psychology (1997), 22(5), 689-705

Assessed pain, anxiety, physical functioning, and cooperativeness in 32 children with spastic cerebral palsy. This is the first study to assess children throughout rehabilitation following selective ... [more ▼]

Assessed pain, anxiety, physical functioning, and cooperativeness in 32 children with spastic cerebral palsy. This is the first study to assess children throughout rehabilitation following selective posterior rhizotomy. Results of the Observational Scale of Behavioral Distress and observer Liken ratings confirmed the hypothesis that children's pain and anxiety decrease over time. Children's physical functioning and cooperativeness improve over time. No significant correlation was found between pain and changes in physical functioning. Cognitive impairment, parental involvement, and children's pain behaviors explained 77% and 56% of the variance in two forms of cooperativeness. Research and clinical implications are discussed, and special considerations regarding pain assessment and management in this population are addressed. [less ▲]

Pair-Wise and Many-Body Dispersive Interactions Coupled to an Optimally Tuned Range-Separated Hybrid Functional

in JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013), 9(8), 3473-3478

We propose a nonempirical, pair-wise or many-body dispersion-corrected optimally tuned range-separated hybrid functional. This functional retains the advantages of the optimal-tuning approach in the ... [more ▼]

We propose a nonempirical, pair-wise or many-body dispersion-corrected optimally tuned range-separated hybrid functional. This functional retains the advantages of the optimal-tuning approach in the prediction of the electronic structure. At the same time, it gains accuracy in the prediction of binding energies for dispersively bound systems, as demonstrated on the S22 and S66 benchmark sets of weakly bound dimers. [less ▲]

Pairwise testing for software product lines: Comparison of two approaches

in Software Quality Journal (2012), 20(3), 605-643

Software Product Lines (SPL) are difficult to validate due to combinatorics induced by variability, which in turn leads to combinatorial explosion of the number of derivable products. Exhaustive testing in ... [more ▼]

Software Product Lines (SPL) are difficult to validate due to combinatorics induced by variability, which in turn leads to combinatorial explosion of the number of derivable products. Exhaustive testing in such a large products space is hardly feasible. Hence, one possible option is to test SPLs by generating test configurations that cover all possible t feature interactions (t-wise). It dramatically reduces the number of test products while ensuring reasonable SPL coverage. In this paper, we report our experience on applying t-wise techniques for SPL with two independent toolsets developed by the authors. One focuses on generality and splits the generation problem according to strategies. The other emphasizes providing efficient generation. To evaluate the respective merits of the approaches, measures such as the number of generated test configurations and the similarity between them are provided. By applying these measures, we were able to derive useful insights for pairwise and t-wise testing of product lines. [less ▲]

La paix des Pyrénées et son impact en Lorraine et au Luxembourg / Der Pyrenäenfriede von 1659 und seine Auswirkungen auf Lothringen und Luxemburg. Actes du colloque international organisé du 5 au 7 novembre 2009 au Musée d'Histoire de la Ville de Luxembourg

Book published by Editions Saint-Paul (2010)

Mit der Unterzeichnung am 7. November 1659 beendet der Pyrenäenfriede (vorübergehend) den Konflikt zwischen den damaligen europäischen Großmächten Spanien und Frankreich. Dieser historische Vertrag muss ... [more ▼]

Mit der Unterzeichnung am 7. November 1659 beendet der Pyrenäenfriede (vorübergehend) den Konflikt zwischen den damaligen europäischen Großmächten Spanien und Frankreich. Dieser historische Vertrag muss im Rahmen der damaligen internationalen Zusammenhänge, der diplomatischen Beziehungen, des Prozesses der Staatenbildung und der Kriegsführung des 17. Jahrhunderts gesehen werden. Der Vertrag hat Auswirkungen sowohl auf europäischer wie auf regionaler Ebene, denn es werden Grenzen nachgezogen und Territorien getauscht. Städte wie Thionville, Montmédy, Damvillers, Marville oder Yvois werden französisch. Die neue Grenze zwischen den Spanischen Niederlanden und Frankreich wird erst nach zähen Verhandlungen festgelegt und gibt Ursache zu vielfältigen Beanstandungen. Der Verlauf wird erst unter österreichischer Herrschaft im Grenzvertrag von 1769 eindeutig geklärt. Doch was bedeuten Grenzlinien im 17. Jahrundert? Wie zeigt sich die Grenze physisch? Was trägt die Kartographie bei? Die französischen Eroberungen führen zur Teilung sehr alter territorialer Einheiten. Es soll untersucht werden, wie die Bevölkerung den Herrschaftswechsel erlebt und gesehen hat. Wurde er einfach hingenommen, oder gibt es im Gegenteil Zeugnisse einer feindlichen Einstellung zu Frankreich? Wie wurde eine Region befriedet, die seit Jahrzehnten in permanenter Unsicherheit lebte? Welche ökonomischen und demographischen Auswirkungen hatte der Vertrag in der luxemburgischen und der lothringischen Region? Leitete er einen wirtschaftlichen und demographischen Niedergang in den annektierten Städten ein? Führte der Vertrag zu einer Neuordnung des politischen und wirtschaftlichen Raumes? Luxemburg verliert seine fruchtbarsten und wirtschaftlich weitest entwickelten Territorien. Allerdings bleiben zahlreiche ökonomische, kulturelle und religiöse Verbindungen über die die neuen Grenzen hinaus bestehen. 350 Jahre später ist der Verlauf dieser Grenze noch immer in der Erinnerung der betroffenen Region präsent. In Luxemburg ist das Jahr 1659 ins kollektive Gedächtnis eingegangen als „erste Teilung“ des nationalen Territoriums. Wie sieht es in Lothringen und im Saarland aus? Hier sollen die Interpretationen des historischen Ereignisses und seiner Konsequenzen durch die verschiedenen nationalen Geschichtsschreibungen verglichen werden. [less ▲]

Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.

in Circulation (2011), 124(24), 2702-15

BACKGROUND: Stress-induced hypertrophic remodeling is a critical pathogenetic process leading to heart failure. Although many signal transduction cascades are demonstrated as important regulators to ... [more ▼]

BACKGROUND: Stress-induced hypertrophic remodeling is a critical pathogenetic process leading to heart failure. Although many signal transduction cascades are demonstrated as important regulators to facilitate the induction of cardiac hypertrophy, the signaling pathways for suppressing hypertrophic remodeling remain largely unexplored. In this study, we identified p21-activated kinase 1 (Pak1) as a novel signaling regulator that antagonizes cardiac hypertrophy. METHODS AND RESULTS: Hypertrophic stress applied to primary neonatal rat cardiomyocytes (NRCMs) or murine hearts caused the activation of Pak1. Analysis of NRCMs expressing constitutively active Pak1 or in which Pak1 was silenced disclosed that Pak1 played an antihypertrophic role. To investigate the in vivo role of Pak1 in the heart, we generated mice with a cardiomyocyte-specific deletion of Pak1 (Pak1(cko)). When subjected to 2 weeks of pressure overload, Pak1(cko) mice developed greater cardiac hypertrophy with attendant blunting of JNK activation compared with controls, and these knockout mice underwent the transition into heart failure when prolonged stress was applied. Chronic angiotensin II infusion also caused increased cardiac hypertrophy in Pak1(cko) mice. Moreover, we discovered that the Pak1 activator FTY720, a sphingosine-like analog, was able to prevent pressure overload-induced hypertrophy in wild-type mice without compromising their cardiac functions. Meanwhile, FTY720 failed to exert such an effect on Pak1(cko) mice, suggesting that the antihypertrophic effect of FTY720 likely acts through Pak1 activation. CONCLUSIONS: These results, for the first time, establish Pak1 as a novel antihypertrophic regulator and suggest that it may be a potential therapeutic target for the treatment of cardiac hypertrophy and heart failure. [less ▲]

Palerme ville syncrétique

Presentation (2018)

The Paley-Wiener theorem for certain nilpotent Lie groups

in Mathematische Nachrichten (2009), 282(10), 1423-1442

The Palgrave Handbook of Childhood Studies

Book published by Palgrave Macmillan (2011)

Palmerston English

in Kortmann, Bernd; Lunkenheimer, Kerstin (Eds.) The Electronic World Atlas of Varieties in English (eWAVE) (2011)

Palmerston English is spoken by just over 50 people on a remote atoll of the Cook Islands in the South Pacific. In 1863, the Englishman William Ma(r)sters settled on Palmerston with several Polynesian ... [more ▼]

Palmerston English is spoken by just over 50 people on a remote atoll of the Cook Islands in the South Pacific. In 1863, the Englishman William Ma(r)sters settled on Palmerston with several Polynesian women from the Northern Group of the Cook Islands. Marsters ruled the island in an autocratic style: only English was allowed to be spoken and it is recorded that the children from his various wives spoke English with a strong British accent. The perpetuation of the speech was more difficult for the women than for the men because they did not have a direct female example from Britain to imitate. The three branches of the family are now in their 8th generation and their offspring live mainly in Rarotonga, Aitutaki, New Zealand and Australia (several thousand people, with a varying degree of competence in the language, depending on the contact retained with Palmerston). [less ▲]