OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entryBréchard, Sabrina ; Salsmann, Alexandre ; Tschirhart, Eric ![]() in Journal of Leukocyte Biology (2009), 85(4), 638-647 The requirement of calcium ion (Ca(2)(+)) entry for neutrophil NADPH oxidase (NOX2) regulation is clearly established. However, its role in the signaling pathway leading to NOX2 activation is still ... [more ▼] The requirement of calcium ion (Ca(2)(+)) entry for neutrophil NADPH oxidase (NOX2) regulation is clearly established. However, its role in the signaling pathway leading to NOX2 activation is still elusive. 1-oleoyl-2-acetyl-sn-glycerol (OAG) causes an increase in NOX2 activity and has been shown to directly modulate Ca(2)(+) channels unrelated to the well-known store-operated Ca(2)(+) entry (SOCE) mechanism. In our study, we have investigated the potential role of OAG in Ca(2)(+) influx-mediated NOX2 activity in neutrophil-like-differentiated HL-60 cells to further characterize second signals involved in the regulation of NOX2. OAG inhibited fMLF- and thapsigargin-induced Ca(2)(+) entry, a phenomenon that was not restored by protein kinase C (PKC) or PI3K blockade. Addition of OAG resulted in a rapid decrease of maximal intracellular Ca(2)(+) concentration induced by thapsigargin. Both results suggest that OAG has an inhibitory effect, independent of PI3K and PKC, on the regulation of SOCE. In contrast to SOCE inhibition, OAG-induced NOX2 activation was mediated by PKC and PI3K. Our data establish that both kinases exert their effects through the regulation of Rac2 activity. In addition, OAG potentiated the effect of fMLF on the activation of NOX2 and led to a discernible activity of NOX2 upon thapsigargin stimulation. In conclusion, our results demonstrate that an additional PKC- and/or PI3K-dependent signal may act in synergy with Ca(2)(+) influx to trigger NOX2 activation. [less ▲] Detailed reference viewed: 144 (0 UL) OAKHQOL: a new instrument to measure quality of live in knee and hip Osteoarthritis; ; et al in Journal of Clinical Epidemiology (2005), 58 To develop a questionnaire with which to measure quality of life (QoL) in patients with knee and hip osteoarthritis (OA). Study Design and Setting: Thirty-two caregivers and 96 OA patients were ... [more ▼] To develop a questionnaire with which to measure quality of life (QoL) in patients with knee and hip osteoarthritis (OA). Study Design and Setting: Thirty-two caregivers and 96 OA patients were interviewed individually (using cognitive and face-to-face techniques) and in focus groups. A group of experts working independently at first and then consensually used the interview transcripts to generate a 46-item questionnaire. Results: Analysis of questionnaires completed by 263 patients with hip or knee OA resulted in the exclusion of three items (two because of low reliability and one because of a low response rate). Principal component analysis revealed four factors: physical activity, mental health, social functioning, and social support. A pain dimension was individualized. Preliminary testing showed the reliability of the five dimensions to be satisfactory (intraclass correlation coefficients: 0.70–0.85), construct validity was adequate when correlated with the SF36 (Spearman correlation coefficients: 0.43–0.75), and discrimination was satisfactory. The osteoarthritis knee and hip quality of life questionnaire (OAKHQOL) consists of 43 items in five dimensions and three independent items. Conclusion: TheOAKHQOLis the first specific knee and hipOAquality of life instrument. Its development followed an a priori structured strategy to ensure content validity. It meets psychometric requirements for validity and reliability. [less ▲] Detailed reference viewed: 83 (2 UL) Oberflächenübersetzung: The Poetics and Cultural Politics of Homophonic TranslationDembeck, Till ![]() in Critical Multilingualism Studies (2015), 3(1), 7-25 This article reassesses the poetics of homophonic translation in order to come to terms with its (culture-)political effects. In a close reading of poems by Ernst Jandl and Oskar Pastior, Dembeck shows ... [more ▼] This article reassesses the poetics of homophonic translation in order to come to terms with its (culture-)political effects. In a close reading of poems by Ernst Jandl and Oskar Pastior, Dembeck shows that these authors’ homophonic translations are by no means homogenous in the methods they apply, but rather make use of various, complex strategies of linguistic transformation simultaneously. This constant shifting between strategies enables these poets to make their texts the medium for (culture-)political movements that are, in very different ways, opposed to the presuppositions of monolingualism. Homophonic translation thus proves to be more than just a mere language game without semantic and political impact. [less ▲] Detailed reference viewed: 243 (5 UL)![]() Oberlotharingien im 15.-17. JahrhundertPauly, Michel ![]() in Voltmer, Rita; Irsigler, Franz (Eds.) Incubi Succubi. Hexen und ihre Henker bis heute. Ein historisches Lesebuch zur Ausstellung (2000) Detailed reference viewed: 64 (0 UL) Obermueller/Werner/Winden - Die Hauptversammlung der Aktiengesellschaft, BuchbesprechungZetzsche, Dirk Andreas ![]() in Zeitschrift für Bank- und Kapitalmarktrecht (2002), (4.Auflage), 1134 Detailed reference viewed: 100 (3 UL) The Obesity Learning Centre (OLC) - a website supporting those working towards a healthy weight and reducing obesity levelsKorjonen, Maria Helena ![]() in Online Journal of Public Health Informatics (2011), 3(1), Objectives: Develop a website, the OLC, which supports those people who work on promoting a healthy weight and tackling obesity. Research shows that original networks where sharing of information and peer ... [more ▼] Objectives: Develop a website, the OLC, which supports those people who work on promoting a healthy weight and tackling obesity. Research shows that original networks where sharing of information and peer interaction take place create solutions to current public health challenges. Methods: Considerations that are relevant when building a new information service as well as the technical set up and information needs of users were taken into account prior to building the OLC and during continuous development and maintenance. Results: The OLC provides global news, resources and tools and link out to other networks, websites and organisations providing similar useful information. The OLC also uses social networking tools to highlight new and important information. Discussion: Networks contribute to a stronger community that can respond to emerging challenges in public health. The OLC improves connections of people and services from different backgrounds and organisations. Some challenges exist in the technical set up and also because of other aspects, e.g. public health information and differing information needs. Conclusion: Public health work programmes should include networking opportunities where public policy can be disseminated. The provision of necessary tools and resources can lead to better decision-making, save time and money and lead to improved public health outcomes. [less ▲] Detailed reference viewed: 108 (0 UL) Obituary: Dieter Ferring (1958-2017)Albert, Isabelle ; Boll, Thomas ; in GeroPsych: Journal of Gerontopsychology and Geriatric Psychiatry (2017), 30(4), 135-136 Memorializes Dieter Ferring, who contributed to life-span developmental psychology, geropsychology, and cultural psychology in research, teaching, professional practice, and political consulting. His life ... [more ▼] Memorializes Dieter Ferring, who contributed to life-span developmental psychology, geropsychology, and cultural psychology in research, teaching, professional practice, and political consulting. His life work centered on life circumstances that included threats to people's well-being and on identifying and implementing solutions for such aversive conditions. His scientific approach was characterized by analysing phenomena in their micro and macro context, by interdisciplinarity, by emphasis on cognitive and semiotic mediation, and by using mixed-method approaches to data collection and analyses. Dieter Ferring had been much engaged in productive cooperations with researchers from other countries in Europe and in disseminating his insights and findings to study programs beyond his own field as well as to the general public. He also served as an expert and research partner to policymakers and community administrators and leaders in practical and applied fields. [less ▲] Detailed reference viewed: 167 (35 UL) Objectifs et compétences dans l’Union européenneNeframi, Eleftheria ![]() Book published by Bruylant (2013) Interaction between objectives and competences of the European Union under the perspective of the principle of conferral. Legal basis of EU action. Member State's obligations beyond EU competence. Detailed reference viewed: 328 (29 UL) L'objectivité dans la théorie d'Umberto EcoTreleani, Matteo ![]() in Travaux en cours. Revue de l'UFR LAC. Université Paris Diderot (2010) Detailed reference viewed: 44 (0 UL) Objects and language in transcontextual communicationBudach, Gabriele ; ; in Social Semiotics (2015), 25(4), 387-400 The text reviews critically the absence of a perspective on materiality (and objects) in most current sociolinguistic research. The authors discuss what an object-oriented perspective can offer for ... [more ▼] The text reviews critically the absence of a perspective on materiality (and objects) in most current sociolinguistic research. The authors discuss what an object-oriented perspective can offer for humanities and social science research. Highlighting the role of objects in human interaction, they identify three types of objects (bounded, boundary and bonding) that have emerged from the case studies in this volume as playing a crucial part in trans-contextual meaning making. [less ▲] Detailed reference viewed: 147 (3 UL) Objects and language in transcontextual communication; ; Budach, Gabriele ![]() in Social Semiotics (2015), 25(4), 387-532 Contributions to this special issue explore the role of objects and language in communication across contexts from interdisciplinary angles, including sociolinguistics, education, anthropology and ... [more ▼] Contributions to this special issue explore the role of objects and language in communication across contexts from interdisciplinary angles, including sociolinguistics, education, anthropology and sociology. The case studies range from medical to educational settings and investigate how meaning is constructed and projected withing and across contexts. [less ▲] Detailed reference viewed: 91 (0 UL) Objektbezogene Informationspflichten des Anlageintermediärs - eine Einordnung des DG-Fonds-Urteils des 11. BGH-Senats vom 7.10.2008Zetzsche, Dirk Andreas ![]() in WM – Wertpapiermitteilungen (2009) Detailed reference viewed: 54 (2 UL)![]() Objet référentiel et objet culturel : une sémio-histoire de la fenêtre dans la littérature européenneThiltges, Sébastian ![]() in Acta Fabula: Revue des Parutions en Théorie Littéraire (2014), 15(8), Detailed reference viewed: 40 (0 UL) Les objets dans la formation Usages, rôles et significationsde Saint-Georges, Ingrid ; Book published by Octares Editions (2010) Quels rôles jouent les objets et les dispositifs techniques dans les activités de formation et d'apprentissage ? Comment rendent-ils l'activité collective viable, ou contribuent-ils à la construction des ... [more ▼] Quels rôles jouent les objets et les dispositifs techniques dans les activités de formation et d'apprentissage ? Comment rendent-ils l'activité collective viable, ou contribuent-ils à la construction des apprentissages ? Le présent ouvrage tente de répondre à ces questions tout en reprenant à nouveaux frais quelques-unes des problématiques actuelles les plus fascinantes des sciences sociales et de l'éducation : la question de l'articulation entre activité individuelle et collective, la négociation collective du sens, la saisie dynamique du cours de l'activité, les réflexions sur les dimensions situées, instrumentées et dynamiques de l'apprentissage. A travers l'analyse d'une dizaine de situations de formation empiriquement attestées, allant de l'école au monde du travail, les contributions analysent les objets dans la dynamique de leur usage. Elles font le point sur les recherches récentes menées à propos des objets dans diverses disciplines et sont autant d'illustrations de la manière dont des approches variées (psychodynamique du travail, approche cours d'action, sociolinguistique interactionnelle, anthropologie cognitive, approches multimodales du discours) peuvent contribuer à illuminer notre compréhension des situations de formation. L'ouvrage s'adresse à toute personne qui s'interroge sur le rôle des objets et du monde matériel dans la vie sociale, l'apprentissage, la formation ou le développement. De manière plus ciblée, il intéresse également les formateurs, chercheurs et/ou praticiens engagés dans la formation des enseignants, dans la formation professionnelle, ou dans la formation des formateurs. Avec les contributions de : David Adé, Bernard Blandin, Christian Brassac, Laurent Filliettaz, Isabelle Fristalon, Nathalie Gal-Petitfaux, Annie Goudeaux, Benoît Huet, Myriam Meuwly-Bonte, Cécile Rossard, Fabrice Roublot, Ingrid de Saint-Georges, Jacques Saury, Carole Sève, Kim Stroumza, Philippe Veyrunes, Olivier Vors. [less ▲] Detailed reference viewed: 348 (1 UL) Les objets ne racontent rienThiltges, Sébastian ![]() Article for general public (2017) Detailed reference viewed: 19 (0 UL) « Les objets qui font parler ». Vers une pédagogie de la création multimodale et multilingueBudach, Gabriele ![]() in LIDIL: Revue de Linguistique et de Didactique des Langues (2018), 57 The text presents an innovative pedagogical approach combining the exploration of material objects and the use of digital technologies. Inspired by studies in multiliteracies and new materialism, the text ... [more ▼] The text presents an innovative pedagogical approach combining the exploration of material objects and the use of digital technologies. Inspired by studies in multiliteracies and new materialism, the text explores a project of animation film making around personally meaningful objects which was conducted with Master students during a Summer School at the University of Luxembourg. Results of this study suggest that exploring material culture and animating it through digital tools can help students to penetrate complex theoretical concepts, such as “the contact zone”, and stimulate language learning, critical thinking and self-expression. [less ▲] Detailed reference viewed: 187 (4 UL) Obligation d'évaluer son client et responsabilité du gestionnaire de portefeuille, note sous Cass. com. fr., 3 mai 2018Riassetto, Isabelle ![]() in Revue de Droit Bancaire et Financier (2018), (4), Detailed reference viewed: 54 (0 UL) L'obligation d'information de l'intermédiaire inscrit sur les événements affectant la vie de l'OPC, note sous Cass. com. fr., 7 mars 2018Riassetto, Isabelle ![]() in Bulletin Joly Bourse (2018) Detailed reference viewed: 64 (1 UL) L'obligation de connaître le client (Know Your Customer) en droit bancaire et financier luxembourgeoisConac, Pierre-Henri ![]() in Revue de Droit Bancaire et Financier (2008), (March-April), 56 Detailed reference viewed: 110 (3 UL) Obligation de contrôle des dépositaires d'OPC, note sous Sanct. AMF, 25 févr. 2013Riassetto, Isabelle ![]() in Bulletin Joly Bourse (2013) Detailed reference viewed: 61 (3 UL) |
||