Nucleation in suspensions of anisotropic colloids

Presentation (2004)

Nucleation of a liquid crystal

Presentation (2004)

Nucleocytoplasmic shuttling of persistently activated STAT3.

in Journal of Cell Science (2007), 120(Pt 18), 3249-61

Persistent activation of the transcription factor STAT3 has been detected in many types of cancer and plays an important role in tumor progression, immune evasion and metastasis. To analyze persistent ... [more ▼]

Persistent activation of the transcription factor STAT3 has been detected in many types of cancer and plays an important role in tumor progression, immune evasion and metastasis. To analyze persistent STAT3 activation we coexpressed STAT3 with v-Src. We found that tyrosine phosphorylation of STAT3 by v-Src is independent of Janus kinases (Jaks), the canonical activators of STATs. The STAT3-induced feedback inhibitor, suppressor of cytokine signaling 3 (SOCS3), did not interfere with STAT3 activation by v-Src. However, the protein inhibitor of activated STAT3 (PIAS3) suppressed gene induction by persistently activated STAT3. We measured nucleocytoplasmic shuttling of STAT3 in single cells by bleaching the YFP moiety of double-labelled STAT3-CFP-YFP in the cytoplasm. Analysis of the subcellular distribution of CFP and YFP fluorescence over time by mathematical modeling and computational parameter estimation revealed that activated STAT3 shuttles more rapidly than non-activated STAT3. Inhibition of exportin-1-mediated nuclear export slowed down nucleocytoplasmic shuttling of v-Src-activated STAT3 resulting in reduced tyrosine phosphorylation, decreased induction of STAT3 target genes and increased apoptosis. We propose passage of persistently activated STAT3 through the nuclear pore complex as a new target for intervention in cancer. [less ▲]

Nueva división internacional del trabajo, diferenciación y superpoblación relativa: un análisis de sus relaciones y determinaciones

in VIII Jornadas de Economía Crítica, Río Cuarto (2015)

Nuevos conocimientos sobre el aprendizaje y la enseñanza de los movimientos.

Scientific Conference (2003, July)

A Null-Space metric for the analysis of partial network observability in sensor location problems

Scientific Conference (2013)

Nullité d'une souscription de parts d'OPCVM pour réticence dolosive, Note sous CA Paris, 30 oct. 2012

in Revue de Droit Bancaire et Financier (2013)

Number magnitude potentiates action judgements

in Experimental Brain Research (2007), 180(3), 525-34

Motor actions can be simulated and generated through the perception of objects and their characteristics. Such functional characteristics of objects with given action capabilities are called affordances ... [more ▼]

Motor actions can be simulated and generated through the perception of objects and their characteristics. Such functional characteristics of objects with given action capabilities are called affordances. Here we report an interaction between the perception of affordances and the processing of numerical magnitude, and we show that the numerical information calibrates the judgement of action even when no actual action is required. In Experiment 1, participants had to judge whether they would be able to grasp a rod lengthways between their thumb and index finger. The presentation of the rod was preceded by a number or a non-numerical symbol. When a small number preceded the rod, participants overestimated their grasp; conversely, when a large number preceded the rods, they underestimated their grasp. In Experiment 2, participants were requested to judge if two successive rods had the same length, a judgement that did not involve any grasping. The numerical primes had no effect on this judgement, showing that the magnitude/affordance interaction was not due to a simple perceptual effect. Finally, Experiment 3 showed that the interaction was not present with a non-numerical ordered sequence, thereby eliminating sequence order as a potentially confounding variable. [less ▲]

Number processing and basal ganglia dysfunction: a single case study.

in Neuropsychologia (2004), 42(8), 1050-62

Numerical processing has never been investigated in a case of Fahr's disease (FD) and only rarely in cases of basal ganglia dysfunction. The study describes the cognitive decline of a pre-morbidly high ... [more ▼]

Numerical processing has never been investigated in a case of Fahr's disease (FD) and only rarely in cases of basal ganglia dysfunction. The study describes the cognitive decline of a pre-morbidly high-functioning patient (medical doctor) affected by FD and his difficulties in number processing. A MRI scan revealed bilateral calcifications in the basal ganglia and a brain PET showed a massive reduction of glucose metabolism in the basal ganglia and both frontal lobes, but no other brain abnormalities. The patient's cognitive deficits included impairments in problem solving, in cognitive set shifting and in mental flexibility, as well as in verbal memory. These deficits are attributed to the disruption of the dorsolateral prefrontal circuit involving the basal ganglia. In number processing, the patient showed a severe deficit in the retrieval of multiplication facts, deficits in all tasks of numerical problem solving and in the execution of complex procedures. Importantly, he also showed a dense deficit in conceptual knowledge, which concerned all test conditions and all operations. The findings confirm the predictions of the triple code model in so far, as a disruption of cortico-subcortical loops involving the basal-ganglia may lead to specific deficits in fact retrieval. However, no verbal deficit, as assumed in the triple code model and reported in similar cases, could be observed. The present findings further add to current knowledge on numerical processing, showing how fronto-executive dysfunction may disrupt conceptual understanding of arithmetic. This study shows that not only parietal lesions may lead to severe deficits in conceptual understanding, but that basal ganglia lesions leading to frontal dysfunction may have a devastating effect. [less ▲]

Number Theory for Cryptography (Lecture Notes)

Learning material (2020)

In these lectures (8 hours taught in November 2020), we mention some topics from (algebraic) number theory as well as some related concepts from (algebraic) geometry that can be useful in cryptography. We ... [more ▼]

In these lectures (8 hours taught in November 2020), we mention some topics from (algebraic) number theory as well as some related concepts from (algebraic) geometry that can be useful in cryptography. We cannot go deeply into any of the topics and most results will be presented without any proofs. One of the things that one encounters are `ideal lattices'. In the examples I saw, this was nothing but (an ideal in) an order in a number field, which is one of the concepts that we present here in its mathematical context (i.e. embedded in a conceptual setting). It has been noted long ago (already in the 19th century) that number fields and function fields of curves have many properties in common. Accordingly, we shall also present some basic topics on affine plane curves and their function fields. This leads us to mention elliptic curves, however, only in an affine version (instead of the better projective one); we cannot go deeply into that topic at all. The material presented here is classical and very well known. [less ▲]