NOWHERELAND REVISITED IN TIMES OF PANDEMIC 2020: LUXEMBOURG POLICY BRIEF

Report (2021)

Undocumented Migrants (UDM) belong to the most vulnerable groups in times of global emergency situations. COVID-19 does hit hardest the most vulnerable groups and it is important to create an evidence ... [more ▼]

Undocumented Migrants (UDM) belong to the most vulnerable groups in times of global emergency situations. COVID-19 does hit hardest the most vulnerable groups and it is important to create an evidence base to guide policy making. The Center for Health and Migration, Vienna, initiated a stock-taking of national regulations concerning access to health and social care for UDM. The initiative aims to create a landscape of policy frameworks to inform policy making and practice development. This Policy Brief provides information on the respective legal frameworks in the following categories: work, housing, compulsory education, social welfare, and health in Luxembourg. [less ▲]

NPD Projects in Search of Top Management Support: The Role of Team Leaders' Social Capital

in M@n@gement (2012), 15(1), 43-75

A number of studies have found that the performance of NPD projects greatly depends on the support they get from top management. However, research into why some projects get more support than others has ... [more ▼]

A number of studies have found that the performance of NPD projects greatly depends on the support they get from top management. However, research into why some projects get more support than others has been limited. The present paper takes a political approach to NPD, in which top management support is considered to be a function of a project leader’s ability to influence decision processes through personal relationships. Mobilizing the bridging perspective of social capital, we argue that project leaders need both strong ties to high-ranking others and sparseness in their networks. Vertical strong ties bring direct support and solidarity, resulting in improved access to resources and priority over other projects; sparseness provides exposure to the full range of information and interpretations in the organization, resulting in a more accurate picture of the political landscape and thus enabling the implementation of an appropriate influence strategy. A PLS analysis of a sample of 73 French project leaders involved in NPD projects provided support for our hypotheses. Hence, we contribute to a very recent stream of research showing that the structural and relational dimensions of social capital are complementary. [less ▲]

NRAS mutant melanoma: Towards better therapies

in Cancer Treatment Reviews (2021), 99

Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy particularly challenging to ... [more ▼]

Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy particularly challenging to treat. Although the development of targeted as well as immunotherapies led to a substantial improvement in the overall survival of non-NRASmut melanoma patients (e.g. BRAFmut), patients with NRASmut melanomas have an overall poorer prognosis due to the high aggressiveness of RASmut tumors, lack of efficient targeted therapies or rapidly emerging resistance to existing treatments. Understanding how NRAS-driven melanomas develop therapy resistance by maintaining cell cycle progression and survival is crucial to develop more effective and specific treatments for this group of melanoma patients. In this review, we provide an updated summary of currently available therapeutic options for NRASmut melanoma patients with a focus on combined inhibition of MAPK signaling and CDK4/6-driven cell cycle progression and mechanisms of the inevitably developing resistance to these treatments. We conclude with an outlook on the most promising novel therapeutic approaches for melanoma patients with constitutively active NRAS. [less ▲]

nsights from a Study on Decision Making in Enterprise Architecture

in In Short Paper Proceedings of the 8th IFIP WG 8.1 Working Conference on the Practice of Enterprise Modeling (PoEM) (2015)

Nüchterne Narrationen. Zum Realismus in Guy Helmingers "Etwas fehlt immer” (2005) und “Morgen war schon” (2007).

in Parr, Rolf; Ernst, Thomas; Conter, Claude D. (Eds.) Guy Helminger. Ein Sprachanatom bei der Arbeit (2014)

Nuclear Energy for Peaceful Purposes:

Presentation (2016, December)

The Nuclear Question, 1954-1982

in Centre Virtuel de la Connaissance sur L'europe (2016)

Franco-British Diplomatic games and issues within the Western European Union (WEU) (1954-1982) http://www.cvce.eu/en/recherche/unit-content/-/unit/e7c423ed-a376-4a57-a415-f8519344e558 2 of 4 texts, which ... [more ▼]

Franco-British Diplomatic games and issues within the Western European Union (WEU) (1954-1982) http://www.cvce.eu/en/recherche/unit-content/-/unit/e7c423ed-a376-4a57-a415-f8519344e558 2 of 4 texts, which were published to accompany the selection of WEU documents for the above-named project, to establish the relevant institutional and historical background to place these documents in their proper context. Published October 2016 by DEIS, (Formerly the CVCE) University of Luxembourg [less ▲]

Nuclear receptors in human immune cells: expressions and correlations

in Molecular Immunology (2007), 44

Nuclear receptors (NR) are key modulators of gene transcription. Their activity is ligand induced and modulates a large variety of tissue-specific cellular functions. However, for many NR little is known ... [more ▼]

Nuclear receptors (NR) are key modulators of gene transcription. Their activity is ligand induced and modulates a large variety of tissue-specific cellular functions. However, for many NR little is known about their role in cells of the immune system. In this study, expression patterns and distribution of 24 NR were investigated in human peripheral blood mononuclear cells.We provide the first evidence of the expression of the 12 receptors CAR, CoupTF , CoupTF , FXR, GCNF, HNF4 , PPAR / , PXR, RevErb , TR2, TR4 and TLX in highly purified CD4, CD8, CD19, CD14 cells. The expression profile of RevErb and LXR previously observed in B cell and macrophages, respectively, has been extended to CD4, CD8 and CD14 cells. Except for RAR , which was absence in any of the cells tested, our results suggest an almost ubiquitous expression of the NR in the different cell lineages of the immune system. The expression of CAR, CoupTF , FXR was also confirmed at a protein level and despite conspicuous mRNA levels of HNF4 , only low levels of this receptor were detectable in the nuclear fraction of PBMCs. Expression of the latter receptors was mostly only a fraction (4–20%) of their expression in the thyroid gland, the adrenal gland, the lung or subcutaneous adipose tissue. The Spearman rank order correlation test was performed to examine the correlation in expression between individual nuclear receptor pairs in the four cell types for several donors. Distinct correlation patterns were observed between receptor pairs in the individual cell types. In CD4 T cells four NR, GCNF, PPAR , PPAR 7 and RevErb are perfectly correlated with each other (P≥0.0167). In the other cell types correlations betweenNRpairs were more diverse, but also statistically highly significant. Interestingly, the relative expression level of a number of receptor pairs ranked identical or similar in at least three (CoupTF and PPAR / , CoupTF andHNF4 as well asROR and PXR) or four cell types (CoupTF and CoupTF , PPAR and RevErb ). Despite the variability of NR expression in immune cells, these results suggest that some of the NR may be co-regulated in human immune cells. [less ▲]

Nucleation in Hard Spheres Systems

Presentation (2011, August)

Nucleation in suspensions of anisotropic colloids

in Computer Physics Communications (2005), 169(1-3), 117-121

We report Monte Carlo studies of liquid crystal nucleation in two types of anisotropic colloidal systems: hard rods and hard ellipsoids. In both cases we find that nucleation pathways differ strongly from ... [more ▼]

We report Monte Carlo studies of liquid crystal nucleation in two types of anisotropic colloidal systems: hard rods and hard ellipsoids. In both cases we find that nucleation pathways differ strongly from the pathways in systems of spherical particles. Short hard rods show an effect of self-poisoning. This part of the article is based on a previous publication [T. Schilling, D. Frenkel, Self-poisoning of crystal nuclei in hard-rod liquids, Phys. Rev. Lett. 92 (2004) 085505]. When a crystallite forms, its surfaces are covered preferentially by rods which align perpendicular to the surface. Therefore subsequent growth is stunted. Hard, almost spherical ellipsoids can be compressed to very high densities without crystallization—in contrast to hard spheres, which crystallize easily. When forced to crystallize, ellipsoids form very loosely aggregated nuclei. In both cases nucleation pathways are complex and it is therefore difficult to define an appropriate reaction coordinate. The common strategies of investigation of nucleation problems (i.e. definition of a coordinate and then sampling barrier crossing with well-known techniques) fail in these systems. [less ▲]