Hypertensive Herzkrankheit - pathophysiologische Grundlaten, Diagnostik und Therapie

in Deutsche Medizinische Wochenschrift (1946) (1990), (39), 1480-1486

HyperVerse - Towards a Self-Organizing and Sustainable Global-Scale Virtual Environment

in Proceedings of the 4th Microsoft Academic Days (MSAD) (2008)

Hypnotherapie

in Techniken der Psychotherapie. (2013)

Hypoglycemia during intensified insulin therapy of young children

in Journal of Pediatric Endocrinology and Metabolism (1998), 11(1), 153-158

Hypothesen über Schrift von in Frankreich aufgewachsenen marokkanischen Grundschulkindern.

in Heinzel, Frederike; Panagiotopoulou, Argyro (Eds.) Qualitative Bildungsforschung im Elementar- und Primarbereich. (2010)

Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles

in Cancers (2020)

Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic events such as invasion, metabolic reprogramming, epithelial–mesenchymal transition, metastasis and resistance to ... [more ▼]

Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic events such as invasion, metabolic reprogramming, epithelial–mesenchymal transition, metastasis and resistance to therapy, all favouring cancer progression. Small extracellular vesicles (EV) shuttle various cargos (proteins, miRNAs, DNA and others). Tumour-derived EVs can be taken up by neighbouring or distant cells in the tumour microenvironment, thus facilitating intercellular communication. The quantity of extracellular vesicle secretion and their composition can vary with changing microenvironmental conditions and disease states. Here, we investigated in melanoma cells the influence of hypoxia on the content and number of secreted EVs. Whole miRNome and proteome profiling revealed distinct expression patterns in normoxic or hypoxic growth conditions. Apart from the well-known miR-210, we identified miR-1290 as a novel hypoxia-associated microRNA, which was highly abundant in hypoxic EVs. On the other hand, miR-23a-5p and -23b-5p were consistently downregulated in hypoxic conditions, while the protein levels of the miR-23a/b-5p-predicted targetIPO11were concomitantly upregulated. Furthermore, hypoxic melanoma EVs exhibit a signature consisting of six proteins (AKR7A2, DDX39B, EIF3C, FARSA, PRMT5, VARS), which were significantly associated with a poor prognosis for melanoma patients, indicating that proteins and/or miRNAs secreted by cancer cells may be exploited as biomarkers. [less ▲]

Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling

in Hepatology (2009), 2009(3),

The interleukin-6-type cytokine oncostatin M (OSM) acts via the Janus kinase/signal transducer and activator of transcription pathway as well as via activation of mitogen-activated protein kinases and is ... [more ▼]

The interleukin-6-type cytokine oncostatin M (OSM) acts via the Janus kinase/signal transducer and activator of transcription pathway as well as via activation of mitogen-activated protein kinases and is known to critically regulate processes such as liver development and regeneration, hematopoiesis, and angiogenesis, which are also determined by hypoxia with the hypoxia-inducible factor 1alpha (HIF1alpha) as a key component. Here we show that treatment of hepatocytes and hepatoma cells with OSM leads to an increased protein level of HIF1alpha under normoxic and hypoxic conditions. Furthermore, the OSM-dependent HIF1alpha increase is mediated via Janus kinase/signal transducer and activator of transcription 3 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 pathways. OSM-mediated HIF1alpha up-regulation did not result from an increase in HIF1alpha protein stability but from increased transcription from the HIF1alpha gene. In addition, we show that the OSM-induced HIF1alpha gene transcription and the resulting enhanced HIF1alpha protein levels are important for the OSM-dependent vascular endothelial growth factor and plasminogen activator inhibitor 1 gene induction associated with several diseases. Conclusion: HIF1alpha levels increase significantly after treatment of hepatocytes and hepatoma cells with OSM, and HIF1alpha contributes to OSM downstream signaling events, pointing to a cross-talk between cytokine and hypoxia signaling in processes such as liver development and regeneration. (HEPATOLOGY 2009.). [less ▲]

Hysteretic behaviour of steel fibre RC coupled shear walls under cyclic loads: Experimental study and modelling

in Engineering Structures (2018)

This paper presents the hysteretic behaviour of three 1/3-scale three-storey steel fibre reinforced concrete (SFRC) coupled shear walls (CSWs) under cyclic loads. The deformation, ductility, energy ... [more ▼]

This paper presents the hysteretic behaviour of three 1/3-scale three-storey steel fibre reinforced concrete (SFRC) coupled shear walls (CSWs) under cyclic loads. The deformation, ductility, energy dissipation, stiffness and crack propagation of the specimens are also discussed and analysed. The results show steel fibre improves the ductility and energy dissipation capacity, and restrains the crack propagation of the CSWs, and delays the degradation of their lateral stiffness and force. Based on the experiments, a simple trilinear model is developed to simulate the skeleton curve of lateral force–displacement of the SFRC CSWs. Through analysing several typical cycles of the hysteretic of these CSWs, the feature points of the proposed hysteretic model are defined which subsequently is used to evaluate the complete hysteretic behaviour of the CSWs. Using existing experimental data and this study, several representative experimental hysteretic cycles are compared with the proposed model. The result indicates a good agreement is reached between the model and experimental results. [less ▲]

H∞ decentralized dynamic-observer-based control for large-scale uncertain nonlinear systems

in IEEE Int. Conf. on Control, Decision and Information Technologies (CoDIT), Metz, France, 3-5 Nov. 2014 (2014, November)

In this paper an H∞ decentralized observer-based control is proposed for large-scale uncertain nonlinear systems. These systems are coupled by N interconnected subsystems where the interconnections ... [more ▼]

In this paper an H∞ decentralized observer-based control is proposed for large-scale uncertain nonlinear systems. These systems are coupled by N interconnected subsystems where the interconnections satisfy the quadratic constraints. The proposed control is based on a new form of dynamic observer (DO) which generalizes the existing results on the proportional observer (PO) and the proportional integral observer (PIO). The design approach is derived from the solution of matrix inequality and based on the algebraic constraints obtained from the analysis of the estimation error. A numerical example is provided to show the effectiveness of the proposed control. [less ▲]

H∞ Filtering of 2-D FM LSS Model with State Delays

in The 27th Chinese Control Conference (2008)

In this paper, we deal with H∞ filtering problem for a class of two-dimensional (2-D) discrete time-invariant systems with state delays described by local state-space (LSS) Fornasini-Marchesini (FM ... [more ▼]

In this paper, we deal with H∞ filtering problem for a class of two-dimensional (2-D) discrete time-invariant systems with state delays described by local state-space (LSS) Fornasini-Marchesini (FM) second model. Based on the bounded real lemma of 2-D state-delayed systems, H∞ filtering design is developed, such that the filtering error system is asymptotically stable and has H∞ performance via LMIs’ feasibility. Furthermore, the minimum H∞ norm bound can be obtained by solving a linear objective optimization problem. A numerical example is given to demonstrate the effectiveness and advantage of our result. [less ▲]