The Human Rights Defence in International Investment Arbitration: Exploring the Limtis of Systemic Integration; Happold, Matthew ![]() in International and Comparative Law Quarterly (2019), 68(3), 741-759 In a variety of investment arbitration cases, respondent States have argued that the measure complained of by the investor was mandated by the State’s human rights obligations. This defence raises ... [more ▼] In a variety of investment arbitration cases, respondent States have argued that the measure complained of by the investor was mandated by the State’s human rights obligations. This defence raises intricate questions concerning the relationship between international investment law and human rights law. Tribunals have generally been reluctant to engage with the argument and to interpret the relationship between investment law and human rights in a straightforward manner. This article discusses two other possibilities: harmonious interpretation and prioritisation. Harmonious interpretation seeks to read provisions from investment treaties and human rights treaties together, whereas prioritisation gives normative superiority to one provision over another. We conclude that harmonious interpretation is facilitated by the discretionary character of common treaty standards in both human rights and investment law, but that the final result is not likely to be very different from prioritisation, because even harmonious interpretation requires that one provision is read in the light of, and thereby subjugated to, another provision. [less ▲] Detailed reference viewed: 322 (8 UL)![]() Human Rights Education on the Rise? Some Global TrendsScientific Conference (2015, June 30) Detailed reference viewed: 101 (3 UL) Human Rights Experimentalism in Action: The Potential of National Human Rights Institutions in Enhancing the Implementation and Monitoring of the Convention on the Rights of Persons with DisabilitiesLichuma, Caroline Omari ; in Journal of Human Rights Practice (2022), 14(1), 108-127 Article 33(2) of the United Nations Convention on the Rights of Persons with Disabilities provides for the establishment and designation of independent monitor- ing mechanisms charged with the promotion ... [more ▼] Article 33(2) of the United Nations Convention on the Rights of Persons with Disabilities provides for the establishment and designation of independent monitor- ing mechanisms charged with the promotion, protection and monitoring of its im- plementation. In numerous States parties, National Human Rights Institutions have been designated as Article 33(2) institutions, either individually or in co-ordination with other bodies, and have consequently made effective contributions to the reporting and inquiry procedures of the Committee on the Rights of Persons with Disabilities. Drawing from experimentalist governance theory, this contribution interrogates whether, and to what extent, this dialogue between locally placed actors and institutions (such as National Human Rights Institutions) on the one hand, and internationally situated actors and institutions (such as the Committee) on the other, has the potential to bolster the implementation of the Convention on the Rights of Persons with Disabilities. At its core, experimentalism proffers a nor- matively attractive vision of how broadly agreed upon goals can be brought to life in a multi-level setting, such as the monitoring mechanism contemplated by the Convention on the Rights of Persons with Disabilities with its unique role and defini- tion for both international and national actors. By analysing Article 33 through an experimentalist governance lens, the contribution thus hopes to highlight a rou- tinely neglected or underestimated aspect of the human rights treaty system, that is, the iterative and dynamic interaction between locally situated actors and institutions and internationally situated actors and institutions, and bring to light what this por- tends for the Convention’s implementation in reality. [less ▲] Detailed reference viewed: 125 (6 UL) Human Rights in the era of Information and Communication TechnologyBartolini, Cesare ; Lenzini, Gabriele ![]() Speeches/Talks (2017) Detailed reference viewed: 197 (10 UL) Human Rights – Inclusion – Education. Interdisciplinary and Comparative Perspectives; ; et al in Bildung und Erziehung (2018), 71(4), 481-482 Detailed reference viewed: 285 (6 UL) Human scoring in CBADoublet, Sophie ; Koenig, Vincent ; Busana, Gilbert et alScientific Conference (2012) Detailed reference viewed: 211 (33 UL) A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling; ; et al in Archives of Toxicology (2021) Detailed reference viewed: 132 (0 UL) Human telomerase reverse transcriptase depletion potentiates the growth- T inhibitory activity of imatinib in chronic myeloid leukemia stem cells; ; Gaigneaux, Anthoula et alin Cancer Letters (2020) Although tyrosine kinase inhibitors (TKIs) revolutionized the management of chronic myeloid leukemia (CML), resistance against TKIs and leukemia stem cell (LSC) persistence remain a clinical concern ... [more ▼] Although tyrosine kinase inhibitors (TKIs) revolutionized the management of chronic myeloid leukemia (CML), resistance against TKIs and leukemia stem cell (LSC) persistence remain a clinical concern. Therefore, new therapeutic strategies combining conventional and novel therapies are urgently needed. Since telomerase is involved in oncogenesis and tumor progression but is silent in most human normal somatic cells, it may be an interesting target for CML therapy by selectively targeting cancer cells while minimizing effects on normal cells. Here, we report that hTERT expression is associated with CML disease progression. We also provide evidence that hTERT-deficient K-562 cells do not display telomere shortening and that telomere length is maintained through the ALT pathway. Furthermore, we show that hTERT depletion exerts a growth-inhibitory effect in K- 562 cells and potentiates imatinib through alteration of cell cycle progression leading to a senescence-like phenotype. Finally, we demonstrate that hTERT depletion potentiates the imatinib-induced reduction of the ALDH+-LSC population. Altogether, our results suggest that the combination of telomerase and TKI should be considered as an attractive strategy to treat CML patients to eradicate cancer cells and prevent relapse by tar- geting LSCs. [less ▲] Detailed reference viewed: 126 (4 UL)![]() Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide; Tschirhart, Eric ![]() in Inflammation Research (2001), 50(7), 357-61 Both N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine, and 1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine induced superoxide release in umbilical cord eosinophils, while no response was observed with ... [more ▼] Both N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine, and 1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine induced superoxide release in umbilical cord eosinophils, while no response was observed with lipopolysaccharide, interleukin-4 and/or interferon-gamma. Furthermore, upon activation with different inflammatory stimuli, neither induction of nitric oxide synthesis nor expression of the constitutive and/or inducible nitric oxide synthase were observed in these eosinophils derived in vitro. Human umbilical cord derived eosinophils are able to produce superoxide as peripheral blood eosinophils. Whether human peripheral eosinophils are capable of NO synthesis is still the subject of considerable debate, nevertheless, our results suggest that these in vitro derived eosinophils are not capable of nitric oxide synthesis. [less ▲] Detailed reference viewed: 206 (0 UL)![]() Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production; Heuschling, Paul ; et alin Journal of Immunological Methods (1997), 205(1), 1-9 In the presence of interleukin-3 and interleukin-5, eosinophil precursors from human umbilical cord blood mononuclear cells were regularly differentiated into mature eosinophil-like cells expressing ... [more ▼] In the presence of interleukin-3 and interleukin-5, eosinophil precursors from human umbilical cord blood mononuclear cells were regularly differentiated into mature eosinophil-like cells expressing normal morphology and cyanide-resistant peroxidase. O2- production and [Ca2+]i rise were measured in these in vitro differentiated eosinophils after fMLP stimulation; with dihydrorhodamine-123 and fura-2, respectively. Umbilical cord blood-derived eosinophils responded to fMLP (0.01 nM to 3 microM) with a concentration-dependent production of O2- (EC50 = 63.1 +/- 17.2 nM; Emax = 71.0 +/- 6.2 pmol/min/10(6) cells). O2- production was correlated with an fMLP concentration-dependent increase in [Ca2+]i (EC50 = 32.5 +/- 14.9 nM; Emax = 200.0 +/- 23.9 nM). These results indicate that human umbilical cord blood-derived eosinophils demonstrate functional characteristics similar to adult human peripheral blood eosinophils after activation by fMLP. Therefore, the large numbers of eosinophils (2-3 x 10(6)/ml cord blood) which can be obtained by culture of human cord blood mononuclear cells may serve as a useful model for future studies which will provide insight into the pathogenesis of diseases associated with eosinophils. [less ▲] Detailed reference viewed: 234 (2 UL)![]() “The human-machine era dawns”: Spanning beyond the computation/linguistics binary; Hoehn, Sviatlana ![]() Scientific Conference (2022, July 14) Detailed reference viewed: 108 (0 UL) Human-Robot Collaboration: Twofold strategy algorithm to avoid collisions using ToF sensorAhmad, Rafiq ; Plapper, Peter ![]() in Applied Mechanics and Materials Journal (2014, December) The importance of Human Robot Interaction to complement human skills in a manufacturing environment with industrial robots increases the concerns over safety of human and the robot. It is necessary to ... [more ▼] The importance of Human Robot Interaction to complement human skills in a manufacturing environment with industrial robots increases the concerns over safety of human and the robot. It is necessary to identify collision risks and avoid them otherwise production stops may cost a huge amount to the industry. A robot working at manufacturing facility should be able to predict potential collisions and must be able to prevent i.e. react automatically for safe detour around obstacle/human. Currently, industrial robots are able to detect collisions after a real contact but the existing proposals for avoiding collisions are either computationally expensive or not very well adapted to human safety. The objective of this paper is to provide intelligence to the industrial robot to predict collision risks and react automatically without stopping the production in a static environment. The proposed approach using Time of Flight (TOF) camera, provides decision regarding trajectory correction and improvement by shifting robot to a secure position. The application presented in this paper is for safe KUKA robot trajectory generation in peg-in-hole assembly process in the laboratory context. [less ▲] Detailed reference viewed: 321 (11 UL) Human-Robot Cooperation in Surface Inspection Aerial Missions; ; et al Scientific Conference (2017, September 21) The goal of the work presented in this paper is to facilitate the cooperation between human opera- tors and aerial robots to perform surface inspec- tion missions. Our approach is based on a model of ... [more ▼] The goal of the work presented in this paper is to facilitate the cooperation between human opera- tors and aerial robots to perform surface inspec- tion missions. Our approach is based on a model of human collaborative control with a mixed ini- tiative interaction. In the paper, we present our human-robot cooperation model based on the combination of a supervisory mode and an as- sistance mode with a set of interaction patterns. We developed a software system implementing this interaction model and carried out several real flight experiments that proved that this ap- proach can be used in aerial robotics for sur- face inspection missions (e.g., in vision based indoor missions). Compared to a conventional tele-operated inspection system, the solution pre- sented in this paper gives more autonomy to the aerial systems, reducing the cognitive load of the operator during the mission development. [less ▲] Detailed reference viewed: 173 (6 UL) Human-Robot-Collaboration for dismantling processesGroß, Sebastian ; ; Plapper, Peter ![]() in Müller, Rainer; Plapper, Peter; Brüls, Olivier (Eds.) et al Robotix-Academy Conference for Industrial Robotics (RACIR) 2017 (2017, October) Remanufacturing of used technical products allows saving of raw material and energy. The complex and mostly manual disassembly of the products prevents the application of remanufacturing in industry. The ... [more ▼] Remanufacturing of used technical products allows saving of raw material and energy. The complex and mostly manual disassembly of the products prevents the application of remanufacturing in industry. The fully automated dismantling can not be achieved and the manual work causes high labour costs. Companies can profit by remanufacturing. Using human-robot collaboration for disassembly allows a certain degree of automation and provides the flexibility and knowledge of the human. This is a promising approach to economically realise a disassembly and remanufacturing of products which are difficult to disassemble or have a high variance. [less ▲] Detailed reference viewed: 186 (0 UL) Humanbezug in der Fort- und Weiterbildung von ErwachsenenSchumacher, Anette ![]() Presentation (2007, April) Detailed reference viewed: 101 (0 UL) L'humanisme dans tous ses états ou la spiritualité plurielle. Hommages à R. BaustertColas-Blaise, Marion ; Wilhelm, Frank ![]() Book published by Presses de l'Université de Lorraine (2014) Detailed reference viewed: 205 (13 UL) Humanitarian Law Implemented: Space Communication in the Service of International Humanitarian LawHofmann, Mahulena ; in Moro-Aguilar, Rafael (Ed.) Humanitarian Law implemented: Space Communication in the Service of International Humanitarian Law (2016) Ius in bello requires concrete measures in order o protect specific groups such as the civilian population. One of the project guaranteeing the fast deployment of satellite communication in context of ... [more ▼] Ius in bello requires concrete measures in order o protect specific groups such as the civilian population. One of the project guaranteeing the fast deployment of satellite communication in context of humanitarian crises is emergency.lu. The article analyses its legal framework. [less ▲] Detailed reference viewed: 164 (2 UL) Humanitarian Law Implemented: Space Communication in the Service of International Humanitarian LawHofmann, Mahulena ; in Masson-Zwaan, Tanja; Blount, Percy (Eds.) Proceedings of the International Institute of Space Law (2015) Ius in bello requires concrete measures in order to protect specific group such as the civilian population. Such measures cannot be implemented without viable communication channels. One of the projects ... [more ▼] Ius in bello requires concrete measures in order to protect specific group such as the civilian population. Such measures cannot be implemented without viable communication channels. One of the projects guaranteeing the fast deployment of satellite communication is the project emergency.lu. [less ▲] Detailed reference viewed: 124 (2 UL) Humanitarian Photography Beyond the Picture: David “CHIM” Seymour’s Children of EuropePriem, Karin ; in Allender, Tim; Dussel, Inés; Grosvenor, Ian (Eds.) et al Appearances Matter: The Visual in Educational History (2021) This book chapter concentrates on photography as a technology that goes beyond the image. The chapter looks at documentary photography as an institutional and material practice of humanitarian ... [more ▼] This book chapter concentrates on photography as a technology that goes beyond the image. The chapter looks at documentary photography as an institutional and material practice of humanitarian ‘propaganda’ and discusses how notions of childhood intensified the urgency of humanitarian campaigns. It analyzes how UNESCO carefully selected and edited David Seymour’s photographs of children of war-devasted Europe, and how the organization adapted and exploited his photographs for its own ends. Besides tracing these practices of meaning making, the chapter also looks at the itinerary of one of Seymour’s most fascinating photographs and the different stories that have evolved around it to the present day. In a nutshell, the essay suggests that photographs, by both providing information and stimulating imagination, become actors of meaning making and storytelling. Photographs did not only help UNESCO manage public consent and add urgency to humanitarian causes; they also triggered public debate on social media, cooperated in historical research, and inspired literary work. [less ▲] Detailed reference viewed: 160 (4 UL) Humanitarian Photography in Post War EuropePriem, Karin ![]() Scientific Conference (2017) Detailed reference viewed: 129 (12 UL) |
||