Jacques Derrida's religion with/out religion and the im/possibility of religious education

in Litchfield, R.G. (Ed.) Leading with hope.The Vocation of the Religious Educator. 2002 Proceedings of the Association of Professors and Researchers in Religious Education. (2002)

Jacques Derrida’s religion with/out religion and the im/possibility of religious education.

in Religious Education (2004), 99(1), 23-37

Jacques Fontanille, Soma et Séma, 2004

in RSSI : Recherches Sémiotiques = RSSI: Semiotic Inquiry (2004), 24(1-3), 299-317

Jahn-Teller, Polarity, and Insulator-to-Metal Transition in BiMnO3 at High Pressure

in Physical Review Letters (2014), 112

The interaction of coexisting structural instabilities in multiferroic materials gives rise to intriguing coupling phenomena and extraordinarily rich phase diagrams, both in bulk materials and strained ... [more ▼]

The interaction of coexisting structural instabilities in multiferroic materials gives rise to intriguing coupling phenomena and extraordinarily rich phase diagrams, both in bulk materials and strained thin films. Here we investigate the multiferroic BiMnO3 with its peculiar 6s2 electrons and four interacting mechanisms: electric polarity, octahedra tilts, magnetism, and cooperative Jahn-Teller distortion. We have probed structural transitions under high pressure by synchrotron x-ray diffraction and Raman spectroscopy up to 60 GPa. We show that BiMnO3 displays under pressure a rich sequence of five phases with a great variety of structures and properties, including a metallic phase above 53 GPa and, between 37 and 53 GPa, a strongly elongated monoclinic phase that allows ferroelectricity, which contradicts the traditional expectation that ferroelectricity vanishes under pressure. Between 7 and 37 GPa, the Pnma structure remains remarkably stable but shows a reduction of the Jahn-Teller distortion in a way that differs from the behavior observed in the archetypal orthorhombic Jahn-Teller distorted perovskite LaMnO3. [less ▲]

Jahrmärkte in Europa im 14.-16. Jahrhundert. Regionale Untersuchungen und der Versuch einer Typologie

in Irsigler, Franz; Pauly, Michel (Eds.) Messen, Jahrmärkte und Stadtentwicklung in Europa (2007)

Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors

in Chemistry & Biology (2011), 18(3), 314-323

Genetic deficiency of Jak3 leads to abrogation of signal transduction through the common gamma chain (γc) and thus to immunodeficiency suggesting that specific inhibition of Jak3 kinase may result in ... [more ▼]

Genetic deficiency of Jak3 leads to abrogation of signal transduction through the common gamma chain (γc) and thus to immunodeficiency suggesting that specific inhibition of Jak3 kinase may result in immunosuppression. Jak1 cooperates with Jak3 in signaling through γc-containing receptors. Unexpectedly, a Jak3-selective inhibitor was less efficient in abolishing STAT5 phosphorylation than pan-Jak inhibitors. We therefore explored the roles of Jak1 and Jak3 kinase functionality in signaling using a reconstituted system. The presence of kinase-inactive Jak1 but not kinase-inactive Jak3 resulted in complete abolishment of STAT5 phosphorylation. Specific inhibition of the "analog-sensitive" mutant AS-Jak1 but not AS-Jak3 by the ATP-competitive analog 1NM-PP1 abrogated IL-2 signaling, corroborating the data with the selective Jak3 inhibitor. Jak1 thus plays a dominant role over Jak3 and these data challenge the notion that selective ATP-competitive Jak3 kinase inhibitors will be effective. © 2011 Elsevier Ltd. [less ▲]

JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms

in JAK-STAT (2013), 2(3), 25025

The Janus kinase 2 (JAK2) mutant V617F and other JAK mutants are found in patients with myeloproliferative neoplasms and leukemias. Due to their involvement in neoplasia and inflammatory disorders, Janus ... [more ▼]

The Janus kinase 2 (JAK2) mutant V617F and other JAK mutants are found in patients with myeloproliferative neoplasms and leukemias. Due to their involvement in neoplasia and inflammatory disorders, Janus kinases are promising targets for kinase inhibitor therapy. Several small-molecule compounds are evaluated in clinical trials for myelofibrosis, and ruxolitinib (INCB018424, Jakafi®) was the first Janus kinase inhibitor to receive clinical approval. In this review we provide an overview of JAK2V617F signaling and its inhibition by small-molecule kinase inhibitors. In addition, myeloproliferative neoplasms are discussed regarding the role of JAK2V617F and other mutant proteins of possible relevance. We further give an overview about treatment options with special emphasis on possible combination therapies. [less ▲]

Jaks and cytokine receptors - an intimate relationship

in Biochemical Pharmacology (2006), 72(11), 1538-46

Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks). These tyrosine kinases are associated with cytokine receptor subunits, they become activated upon ... [more ▼]

Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks). These tyrosine kinases are associated with cytokine receptor subunits, they become activated upon receptor triggering and subsequently activate downstream signalling events, e.g. the phosphorylation of STAT transcription factors. The successful interplay between cytokines, their receptors and the connected Jaks not only determines signalling competence but is also vital for intracellular traffic, stability, and fate of the cognate receptors. Here, we will discuss underlying mechanisms as well as some structural features with a focus on Jak1 and two of the signal transducing receptor subunits of interleukin (IL)-6 type cytokines, gp130 and OSMR. Regions that are critically involved in Jak-binding have been identified for many cytokine receptor subunits. In most cases the membrane-proximal parts comprising the box1 and box2 regions within the receptor are involved in this association while, within Jaks, the N-terminal FERM domain, possibly together with the SH2-like domain, are pivotal for binding to the relevant receptors. The exclusive membrane localisation of Jaks depends on their ability to associate with cytokine receptors. For gp130 and Jak1, it was shown that the cytokine receptor/Jak complex can be regarded as a receptor tyrosine kinase since both molecules have the same diffusion dynamics and are virtually undissociable. Furthermore, Jaks take an active role in the regulation of the surface expression of at least some cytokine receptors, including the OSMR and this may provide a quality control mechanism ensuring that only signalling-competent receptors (i.e. those with an associated Jak) would be enriched at the cell surface. [less ▲]

JAM-C is an apical surface marker for neural stem cells.

in Stem Cells & Development (2012), 21(5), 757-66

Junctional adhesion molecule-C (JAM-C) is an adhesive cell surface protein expressed in various cell types. JAM-C localizes to the apically localized tight junctions (TJs) between contacting endothelial ... [more ▼]

Junctional adhesion molecule-C (JAM-C) is an adhesive cell surface protein expressed in various cell types. JAM-C localizes to the apically localized tight junctions (TJs) between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesions. Just as those epithelial cells, also neural stem cells are highly polarized along their apical-basal axis. The defining feature of all stem cells, including neural stem cells (NSCs) is their ability to self renew. This self-renewal depends on the tight control of symmetric and asymmetric cell divisions. In NSCs, the decision whether a division is symmetric or asymmetric largely depends on the distribution of the apical membrane and cell fate determinants on the basal pole of the cell. In this study we demonstrate that JAM-C is expressed on neural progenitor cells and neural stem cells in the embryonic as well as the adult mouse brain. Furthermore, we demonstrate that in vivo JAM-C shows enrichment at the apical surface and therefore is asymmetrically distributed during cell divisions. These results define JAM-C as a novel surface marker for neural stem cells. [less ▲]

JANE - The Java Ad Hoc Network Development Environment

in 40th Annual Simulation Symposium, 2007. ANSS '07. (2007)

This work describes a Java based development platform which is intended to support ad hoc network researchers in application and protocol design. Software development within this environment is expected ... [more ▼]

This work describes a Java based development platform which is intended to support ad hoc network researchers in application and protocol design. Software development within this environment is expected to follow a bottom up approach. Basic functionality is implemented in elementary components which can be combined to more complex ones by using well defined interfaces. With dynamically changing network links being rather the common case than a failure situation, asynchronous communication has been selected as the main communication paradigm within this platform. Reusability of components in different execution contexts by providing an appropriate machine abstraction is a further important design decision which drove the platform development. Code written once can be executed in a pure simulation mode, in a hybrid setting with real devices being attached to a running simulation and, finally, in a setting using real devices only. Software development following this three-tier development process paired with the platform's rich visualization features emerged to significantly ease the burden of debugging and parameterizing in such highly dynamic and inherently distributed environments. In conjunction with a core middleware platform a rich set of generic services has been implemented with the most important ones being described in this work. Several application programs have already been implemented on top of these services. These applications which are described in this work as well serve as a proof of concept for both the platform itself and the utilized set of generic services [less ▲]