Global Challenges: Opening up Chemistry, Pandemics, and Air PollutionSchymanski, Emma ![]() in ACS Environmental Au (2022), 2(4), 287--289 As the first half of 2022 comes to a close, it is an interesting time to reflect on some recent trends. In many ways, the world is “opening” up again, with many colleagues going to their first “in person” ... [more ▼] As the first half of 2022 comes to a close, it is an interesting time to reflect on some recent trends. In many ways, the world is “opening” up again, with many colleagues going to their first “in person” conferences since the start of the pandemic in early 2020. A significant leap forward for open chemistry was made in 2021, with the Chemical Abstracts Service (CAS) Registry embracing a hybrid model and releasing half a million chemicals as the CAS Common Chemistry set under an open license. (1)ACS Environmental Au continues to develop as one of the key gold open access journals for publishing work on environmental topics. (2) The European Union has just launched the €400 million European Partnership for the Assessment of Risks from Chemicals (PARC), with ∼200 partners (3) and a whole work package on FAIR (Findable, Accessible, Interoperable, Reusable) (4,5) and Open (6) data. While these trends are cause for optimism, the CAS Registry continues to climb toward the 200 million chemical mark (7) and many of us were blown away by the sheer immensity of the chemical pollution problem at recent meetings. Other colleagues, e.g., those affected by war, by lockdowns, or with insufficient funds, are unable to share in the “post-pandemic” reopening, conferences, and travel. Others cannot afford the costs associated with open access or still do not see the benefits of open science. Why the focus on these disjoint subjects? Both chemical pollution and the COVID-19 pandemic are global challenges requiring global solutions, where failure to act comes with a high price. Landrigan et al. estimated that 9 million premature deaths (16% of the global total) were caused by pollution in 2015. (8) Worldwide deaths directly due to the COVID-19 pandemic are already over 6 million (9) (January 2020 to May 2022). While public awareness is high, individuals often feel powerless to tackle global challenges─yet the pandemic has proven that individual actions can make an incredible collective difference. The same applies to open data and the exchange of research results─the collective benefit from many individual contributions can be extraordinary. [less ▲] Detailed reference viewed: 148 (0 UL) Occurrence and Distribution of Pharmaceuticals and Their Transformation Products in Luxembourgish Surface WatersSingh, Randolph ; Lai, Adelene ; Krier, Jessy et alin ACS Environmental Au (2021) Pharmaceuticals and their transformation products (TPs) are continuously released into the aquatic environment via anthropogenic activity. To expand knowledge on the presence of pharmaceuticals and their ... [more ▼] Pharmaceuticals and their transformation products (TPs) are continuously released into the aquatic environment via anthropogenic activity. To expand knowledge on the presence of pharmaceuticals and their known TPs in Luxembourgish rivers, 92 samples collected during routine monitoring events between 2019 and 2020 were investigated using nontarget analysis. Water samples were concentrated using solid-phase extraction and then analyzed using liquid chromatography coupled to a high-resolution mass spectrometer. Suspect screening was performed using several open source computational tools and resources including Shinyscreen (https://git-r3lab.uni.lu/eci/shinyscreen/), MetFrag (https://msbi.ipb-halle.de/MetFrag/), PubChemLite (https://zenodo.org/record/4432124), and MassBank (https://massbank.eu/MassBank/). A total of 94 pharmaceuticals, 88 confirmed at a level 1 confidence (86 of which could be quantified, two compounds too low to be quantified) and six identified at level 2a, were found to be present in Luxembourg rivers. Pharmaceutical TPs (12) were also found at a level 2a confidence. The pharmaceuticals were present at median concentrations up to 214 ng/L, with caffeine having a median concentration of 1424 ng/L. Antihypertensive drugs (15), psychoactive drugs (15), and antimicrobials (eight) were the most detected groups of pharmaceuticals. A spatiotemporal analysis of the data revealed areas with higher concentrations of the pharmaceuticals, as well as differences in pharmaceutical concentrations between 2019 and 2020. The results of this work will help guide activities for improving water management in the country and set baseline data for continuous monitoring and screening efforts, as well as for further open data and software developments. [less ▲] Detailed reference viewed: 148 (3 UL) |
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