Some inequalities on Riemannian manifolds linking Entropy, Fisher information, Stein discrepancy and Wasserstein distance; Thalmaier, Anton ; E-print/Working paper (2021) For a complete connected Riemannian manifold M let V∊ C^2(M) be such that µ(dx)=exp(-V(x))vol(dx) is a probability measure on M. Taking µ as reference measure, we derive inequalities for probability ... [more ▼] For a complete connected Riemannian manifold M let V∊ C^2(M) be such that µ(dx)=exp(-V(x))vol(dx) is a probability measure on M. Taking µ as reference measure, we derive inequalities for probability measures on M linking relative entropy, Fisher information, Stein discrepancy and Wasserstein distance. These inequalities strengthen in particular the famous log-Sobolev and transportation-cost inequality and extend the so-called Entropy/Stein-discrepancy/Information (HSI) inequality established by Ledoux, Nourdin and Peccati (2015) for the standard Gaussian measure on Euclidean space to the setting of Riemannian manifolds. [less ▲] Detailed reference viewed: 35 (6 UL) Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications; ; et al in Brain (2021) We report detailed functional analyses and genotype-phenotype correlations in 392 individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ channel NaV1.6, with the aim of ... [more ▼] We report detailed functional analyses and genotype-phenotype correlations in 392 individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ channel NaV1.6, with the aim of describing clinical phenotypes related to functional effects. Six different clinical subgroups could be identified: 1) Benign familial infantile epilepsy (BFIE) (n = 15, normal cognition, treatable seizures), 2) intermediate epilepsy (n = 33, mild ID, partially pharmaco-responsive), 3) developmental and epileptic encephalopathy (DEE, n = 177, severe ID, majority pharmaco-resistant), 4) generalized epilepsy (n = 20, mild to moderate ID, frequently with absence seizures), 5) unclassifiable epilepsy (n = 127), and 6) neurodevelopmental disorder without epilepsy (n = 20, mild to moderate ID). Groups 1–3 presented with focal or multifocal seizures (median age of onset: four months) and focal epileptiform discharges, whereas the onset of seizures in group 4 was later (median: 42 months) with generalized epileptiform discharges. We performed functional studies expressing missense variants in ND7/23 neuroblastoma cells and primary neuronal cultures using recombinant tetrodotoxin-insensitive human NaV1.6 channels and whole-cell patch-clamping. Two variants causing DEE showed a strong gain-of-function (GOF, hyperpolarising shift of steady-state activation, strongly increased neuronal firing rate), and one variant causing BFIE or intermediate epilepsy showed a mild GOF (defective fast inactivation, less increased firing). In contrast, all three variants causing generalized epilepsy induced a loss-of-function (LOF, reduced current amplitudes, depolarising shift of steady-state activation, reduced neuronal firing). Including previous studies, functional effects were known for 170 individuals. All 136 individuals carrying a functionally tested GOF variant had either focal (97, groups 1–3), or unclassifiable epilepsy (39), whereas 34 with a LOF variant had either generalized (14), no (11) or unclassifiable (6) epilepsy; only three had DEE. Computational modeling in the GOF group revealed a significant correlation between the severity of the electrophysiological and clinical phenotypes. GOF variant carriers responded significantly better to sodium channel blockers (SCBs) than to other anti-seizure medications, and the same applied for all individuals of groups 1–3.In conclusion, our data reveal clear genotype-phenotype correlations between age at seizure onset, type of epilepsy and gain- or loss-of-function effects of SCN8A variants. Generalized epilepsy with absence seizures is the main epilepsy phenotype of LOF variant carriers and the extent of the electrophysiological dysfunction of the GOF variants is a main determinant of the severity of the clinical phenotype in focal epilepsies. Our pharmacological data indicate that SCBs present a treatment option in SCN8A-related focal epilepsy with onset in the first year of life. [less ▲] Detailed reference viewed: 36 (1 UL) UAV Relay-Assisted Emergency Communications in IoT Networks: Resource Allocation and Trajectory OptimizationTran Dinh, Hieu ; Nguyen, van Dinh ; Chatzinotas, Symeon et alin IEEE Transactions on Wireless Communications (2021) Unmanned aerial vehicle (UAV) communication hasemerged as a prominent technology for emergency communi-cations (e.g., natural disaster) in the Internet of Things (IoT)networks to enhance the ability of ... [more ▼] Unmanned aerial vehicle (UAV) communication hasemerged as a prominent technology for emergency communi-cations (e.g., natural disaster) in the Internet of Things (IoT)networks to enhance the ability of disaster prediction, damageassessment, and rescue operations promptly. A UAV can bedeployed as a flying base station (BS) to collect data from time-constrained IoT devices and then transfer it to a ground gateway(GW). In general, the latency constraint at IoT devices and UAV’slimited storage capacity highly hinder practical applicationsof UAV-assisted IoT networks. In this paper, full-duplex (FD)radio is adopted at the UAV to overcome these challenges. Inaddition, half-duplex (HD) scheme for UAV-based relaying isalso considered to provide a comparative study between twomodes (viz., FD and HD). Herein, a device is considered tobe successfully served iff its data is collected by the UAV andconveyed to GW timely during flight time. In this context,we aim to maximize the number of served IoT devices byjointly optimizing bandwidth, power allocation, and the UAVtrajectory while satisfying each device’s requirement and theUAV’s limited storage capacity. The formulated optimizationproblem is troublesome to solve due to its non-convexity andcombinatorial nature. Towards appealing applications, we firstrelax binary variables into continuous ones and transform theoriginal problem into a more computationally tractable form.By leveraging inner approximation framework, we derive newlyapproximated functions for non-convex parts and then develop asimple yet efficient iterative algorithm for its solutions. Next,we attempt to maximize the total throughput subject to thenumber of served IoT devices. Finally, numerical results showthat the proposed algorithms significantly outperform benchmarkapproaches in terms of the number of served IoT devices andsystem throughput. [less ▲] Detailed reference viewed: 28 (3 UL) Normative coherence for development – What relevance for responsive regionalism?Koff, Harlan ; Häbel, Sandra ![]() in Development Policy Review (2021) Without a normative dimension, transformative development risks reproducing traditional economic development. In this special issue we focus on norm implementation in different world regions through the ... [more ▼] Without a normative dimension, transformative development risks reproducing traditional economic development. In this special issue we focus on norm implementation in different world regions through the lens of normative coherence for development. This special issue indicates that regions are an important interlocutor between the global, national, and sub-national level and, as such, are crucial for implementing the sustainable development agenda. The articles show, however, that to date normative coherence for development has not been achieved due to overriding priorities and technical approaches to policy coherence for development. With this special issue we aim to draw more attention to the topic of normative coherence for development and show that policies need to be adjusted in order to reflect the normative dimension of sustainable development. [less ▲] Detailed reference viewed: 16 (0 UL) Role of higher-order effects in spin-misalignment small-angle neutron scattering of high-pressure torsion nickel; Bersweiler, Mathias ; et alin Physical Review Materials (2021), 5 Detailed reference viewed: 15 (0 UL) Teacher expectations and emotions concerning students with special needs or immigrant backgroundPit-Ten Cate, Ineke ; Krischler, Mireille ![]() Scientific Conference (2021, August 23) Teachers are faced with increasingly heterogenous student groups, whereby the successful inclusion of all students largely depend on teachers´ competence and attitudes. Attitudes are understood as a ... [more ▼] Teachers are faced with increasingly heterogenous student groups, whereby the successful inclusion of all students largely depend on teachers´ competence and attitudes. Attitudes are understood as a multifaceted construct with cognitive, affective and conative components. In the current study we investigated to what extent teachers´ expectations concerning students´ academic performance - reflecting the cognitive component of attitudes - varied as a function of specific student characteristics (special educational needs and immigrant background). In addition, we assessed teachers´ emotions - reflecting the affective component of attitudes - concerning the inclusion of these students in mainstream education. Result confirmed previous findings that teachers´ expectations and emotions vary as a function of student characteristics. Teachers had lower expectations of the academic performance of students with learning difficulties than students with challenging behaviour, whereby the estimates of German proficiency were also affected by the immigrant background of the student. Teachers felt however less positive about the inclusion of students with challenging behaviour than of students with learning difficulties, regardless of the immigrant background of the student. Results will be discussed in relation to theory and their practical implications. [less ▲] Detailed reference viewed: 31 (0 UL) A research-practice cooperation to support elementary school teachers’ diagnostic competencies based on a working theory of talent development in STEMKrischler, Mireille ; ; et alin Gifted and Talented International (2021) We present a teacher professionalization project for promoting elementary school teachers’ diagnostic competencies in recognizing their students’ potential in STEM subjects. Teacher professionalization is ... [more ▼] We present a teacher professionalization project for promoting elementary school teachers’ diagnostic competencies in recognizing their students’ potential in STEM subjects. Teacher professionalization is fostered through the teachers’ personal involvement in the development of subjectspecific diagnostic materials as well as through continuing training on the fundamental knowledge needed to detect and support gifted students. On the basis of the Talent Development in Achievement Domains (TAD) framework, we reached a common working theory of talent and its development in mathematics and science for elementary school-aged students based on the available scientific evidence and approved by teachers. We share a multidimensional, dynamic view of talent development that includes abilities, personality traits, and skills. We describe how our working theory and diagnostic materials can foster teachers’ diagnostic competencies as well as talent discovery and promotion in order to foster students’ development of creative productivity in STEM fields. [less ▲] Detailed reference viewed: 18 (0 UL) Quantum-mechanical force balance between multipolar dispersion and Pauli repulsion in atomic van der Waals dimersVaccarelli, Ornella ; Fedorov, Dmitry ; Stoehr, Martin et alin Physical Review Research (2021) Detailed reference viewed: 16 (1 UL) Almost global convergence to practical synchronization in the generalized Kuramoto model on networks over the n-sphereMarkdahl, Johan ; Proverbio, Daniele ; et alin Communications Physics (2021), 4 From the flashing of fireflies to autonomous robot swarms, synchronization phenomena are ubiquitous in nature and technology. They are commonly described by the Kuramoto model that, in this paper, we ... [more ▼] From the flashing of fireflies to autonomous robot swarms, synchronization phenomena are ubiquitous in nature and technology. They are commonly described by the Kuramoto model that, in this paper, we generalise to networks over n-dimensional spheres. We show that, for almost all initial conditions, the sphere model converges to a set with small diameter if the model parameters satisfy a given bound. Moreover, for even n, a special case of the generalized model can achieve phase synchronization with nonidentical frequency parameters. These results contrast with the standard n = 1 Kuramoto model, which is multistable (i.e., has multiple equilibria), and converges to phase synchronization only if the frequency parameters are identical. Hence, this paper shows that the generalized network Kuramoto models for n ≥ 2 displays more coherent and predictable behavior than the standard n = 1 model, a desirable property both in flocks of animals and for robot control. [less ▲] Detailed reference viewed: 41 (0 UL) Optimal Motion Planning and Control with Safety Guarantees for Aerial RobotsCastillo López, Manuel ![]() Doctoral thesis (2021) Autonomous aerial robots are expected to revolutionize many industries, such as construction, transportation or even space exploration. However, to target an industry where different robots and humans are ... [more ▼] Autonomous aerial robots are expected to revolutionize many industries, such as construction, transportation or even space exploration. However, to target an industry where different robots and humans are meant to share the same space our algorithms need to provide safety and efficiency guarantees. Navigating autonomously in these kind of environments poses a great challenge. We may face a significant number of obstacles, and we can only estimate where they are and where they are expected to be, but not exactly. Dealing with these uncertainties is a challenging problem in most robotics applications, including motion planning and control. During the last decade, major contributions have established the theoretical basis upon which optimal motion planning and control with safety guarantees can be achieved. However, they involve a high computational cost that scales exponentially with the number of obstacles, rendering a limited domain of robotic applications. The main contribution of this thesis provides an efficient, scalable and safe approximation to this problem, allowing its application to embedded systems with fast dynamics such as aerial robots. This thesis also includes an additional contribution that allow these methods to plan longer trajectories with a minimal computational footprint, allowing to better anticipate evasive maneuvers. These contributions have been validated mathematically, in simulation and in real-time operation on aerial robots, handling uncertain dynamic obstacles such as pedestrians. [less ▲] Detailed reference viewed: 29 (2 UL) Towards a computer-assisted aesthetics of user responseArmaselu, Florentina ![]() in Digital Scholarship in the Humanities (2021) The article focuses on the analysis of the user as an aesthetic category and proposes a methodology for evaluating user response within a framework that combines theoretical background from different ... [more ▼] The article focuses on the analysis of the user as an aesthetic category and proposes a methodology for evaluating user response within a framework that combines theoretical background from different areas, the theory of aesthetic response, psycholinguistics, appraisal theory, dialogism, and affective stylistics, with the application of digital tools for corpus linguistics and sentiment analysis. Four user types were derived from the corpus linguistics analysis referred to as immersed, distant, sceptical, and enthusiastic users. Each type may encompass a certain degree of intentionality and convey an attitude, implying features such as commitment and honesty, objectivity and engagement with the audience, critical reflection and circumspection, openness to technological novelty, and enjoyment. This assumes that the users involved in usability testing are not neutral or undifferentiated informational entities placed in an experimental context but individuals that respond to the same stimuli and express themselves differently in light of psycholinguistic factors and rules of social interaction. On the other hand, the results of sentiment analysis showed that an experiential analysis, centred not only on the artefact but also on the response and the experience it generates, may enable understanding the user as involved in a hermeneutic process of interpretation during his/her interaction with the studied artefact. Given the small scale of the analysed data, the study does not intend to provide evidence for general or definitive statements but formulates and illustrates a set of interpretative hypotheses and methodological directions for further enquiry aiming at developing an ‘aesthetics’ of user response. [less ▲] Detailed reference viewed: 135 (14 UL) Systematic approaches to social protection; Cebotari, Victor ; in Schüring, Esther; Loewe, Markus (Eds.) Handbook of Social Protection Systems (2021) Detailed reference viewed: 60 (0 UL) ARL – Akademie für RaumePostwachstum und Raumentwicklung – Denkanstöße für Wissenschaft und Praxis.; ; et al Report (2021) This position paper, drawn up by members of the ARL’s Working Group on Post-Growth Economies (2016 – 2020), situates the international post-growth debate and discusses its relevance for spatial ... [more ▼] This position paper, drawn up by members of the ARL’s Working Group on Post-Growth Economies (2016 – 2020), situates the international post-growth debate and discusses its relevance for spatial development and spatial science research. In addition to sectoral approaches and findings, the authors make concrete proposals for post-growth focuses in planning, research and teaching, distinguishing between changes that can be achieved in the short term and measures designed for the medium to long term. [less ▲] Detailed reference viewed: 60 (0 UL) A Catalogus Immune Muris of the mouse immune responses to diverse pathogensDel Sol Mesa, Antonio ![]() in Cell Death and Disease (2021) Detailed reference viewed: 32 (2 UL) Numerical study on design rules for minimum degree of shear connection in propped steel-concrete composite beams; Odenbreit, Christoph ; Romero, Alfredo ![]() in Engineering Structures (2021), 241 This manuscript presents a numerical study on simply supported propped composite beams with ductile shear connectors subjected to uniformly distributed load. The aim is to assess the performance of the ... [more ▼] This manuscript presents a numerical study on simply supported propped composite beams with ductile shear connectors subjected to uniformly distributed load. The aim is to assess the performance of the revised rules for the minimum degree of shear connection (CEN/TC250/SC4.T3) with respect to the occurring slip. First, a non-linear 3D finite element model was developed through the software ABAQUS 2017 and validated against analytical values of the elastic stiffness and plastic bending resistance. Then, 91 configurations were analysed for different degrees of shear connection η=0.2,0.4…1.0. The span ranges from 6 to 25 m while the geometrical and mechanical properties varied within their typical field of applicability. According to both current and revised rules, 16 configurations with relatively deep beam and “weak” concrete slab exhibited allowable slip values smax significantly higher than 6 m. Therefore, the authors proposed a reduction of the maximum degree of utilization to these special cases. If the proposed reduction is included in the revised rules, none of the considered cases exhibit a slip smax higher than 8 mm while few cases have smax between 6 and 8 mm. For the ease of use, a design proposal is reformulated as a conditional reduction of the plastic bending resistance of the composite section. [less ▲] Detailed reference viewed: 115 (6 UL) Wideband OFDM-based Communications in Bus Topology as a Key Enabler for Industry 4.0 NetworksGonzalez Rios, Jorge Luis ; ; et alin IEEE Access (2021), 9 The Industry 4.0 paradigm conceives a cyber-physical supporting framework for the manufacturing processes in smart factories. In this context, solutions concerning the wired communications at the field ... [more ▼] The Industry 4.0 paradigm conceives a cyber-physical supporting framework for the manufacturing processes in smart factories. In this context, solutions concerning the wired communications at the field-level have been reported which utilize either fieldbuses, which exhibit a huge distance range but a reduced data rate in a bus topology, or Ethernet-based technologies, which provide an increased data rate but reduced distance in a ring topology. To overcome this shortage, we propose the use of orthogonal frequency division multiplexing (OFDM) to significantly increase the achievable data rates over large distances in industrial bus systems. Also, we establish a novel methodology to compute the signal-to-noise ratio between arbitrary pairs of nodes, which in turn allows to compute the communication capacity. Our wideband system was validated by connecting up to 32 nodes in the distance range 100 m–1 km. Compared to fieldbuses, the results of the proposal exhibit an amazing improvement in data rate of about fifty times for 100m distance and more than ten times for 0.5 km. Moreover, with respect to Ethernet-based solutions, the results show a relevant improvement in the data rate of around five times for 100 m distance, but Ethernet-based systems cannot go beyond this distance, to which our proposal is not limited. [less ▲] Detailed reference viewed: 64 (9 UL) Psychological wellbeing of parents of very young children with type 1 diabetes – baseline assessment; Pit-Ten Cate, Ineke ; et alin Frontiers in Endocrinology (2021), 12(721028), Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between ... [more ▼] Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental wellbeing and child behavior. Methods: All parents were invited to fill in baseline questionnaires: hypoglycemia fear survey (HFS), WHO-5, Epworth Sleepiness Scale and Strength and Difficulties Questionnaire (SDQ). Results: 24 children (median age: 5-year, range 1-7 years, 63% male, mean diabetes duration: 3 ± 1.7 years) participated. 23/24 parents filled out the questionnaires. We found a higher score for the hypoglycemia fear behavior 33.9 ± 5.6 compared to hypoglycemia worry 34.6 ± 12.2. Median WHO-5 score was 16 (8 - 22) with poor well-being in two parents. Median daytime sleepiness score was high in five parents (>10). For six children a high total behavioral difficulty score (>16) was reported. Pro social behavior score was lower than normal in six children (<6). Parental well-being was negatively associated with HFS total (r = - 0.50, p <.05) and subscale scores (r = - 0.44, p <.05 for HFS-Worry and HFS-Behavior), child behavior (r = - 0.45, p = .05) and positively with child age (r = 0.58, p <.01). HFS, parental well-being nor daytime sleepiness are associated with the HbA1c. Conclusion: Regular screening of parental well-being, hypoglycemia fear and child behavior should be part of routine care to target early intervention. [less ▲] Detailed reference viewed: 40 (4 UL) ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1; Gerard, Déborah ; et alin Frontiers in Oncology (2021) Detailed reference viewed: 16 (1 UL) Ernährungssouveränität: Transformation des ErnährungssystemsReckinger, Rachel ; Article for general public (2021) Detailed reference viewed: 33 (2 UL) Proneural genes define ground-state rules to regulate neurogenic patterning and cortical foldingDel Sol Mesa, Antonio ![]() in Neuron (2021) Detailed reference viewed: 31 (0 UL) |
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