Merging judgments and the problem of truth-tracking

Scientific Conference (2006, December 07)

Mobilités pendulaires et résidentielles dans et vers le bassin d'emploi du Luxembourg

E-print/Working paper (2006)

Selbstgesteuerte Skifahren lernen?

in Bach, Inge (Ed.) Skilauf und Snowboard in Forschung und Lehre (2006, December)

Tour d'horizon sur l'utilisabilité - U-Lab et autres outils d'évaluation

Conference given outside the academic context (2006)

Michaux et l’épopée indienne : rites, rixes, remblais

Speeches/Talks (2006)

Schulklima und Gewalt - Ein Überblick zum aktuellen Forschungsstand

Scientific Conference (2006, November)

Jaks and cytokine receptors - an intimate relationship

in Biochemical Pharmacology (2006), 72(11), 1538-46

Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks). These tyrosine kinases are associated with cytokine receptor subunits, they become activated upon ... [more ▼]

Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks). These tyrosine kinases are associated with cytokine receptor subunits, they become activated upon receptor triggering and subsequently activate downstream signalling events, e.g. the phosphorylation of STAT transcription factors. The successful interplay between cytokines, their receptors and the connected Jaks not only determines signalling competence but is also vital for intracellular traffic, stability, and fate of the cognate receptors. Here, we will discuss underlying mechanisms as well as some structural features with a focus on Jak1 and two of the signal transducing receptor subunits of interleukin (IL)-6 type cytokines, gp130 and OSMR. Regions that are critically involved in Jak-binding have been identified for many cytokine receptor subunits. In most cases the membrane-proximal parts comprising the box1 and box2 regions within the receptor are involved in this association while, within Jaks, the N-terminal FERM domain, possibly together with the SH2-like domain, are pivotal for binding to the relevant receptors. The exclusive membrane localisation of Jaks depends on their ability to associate with cytokine receptors. For gp130 and Jak1, it was shown that the cytokine receptor/Jak complex can be regarded as a receptor tyrosine kinase since both molecules have the same diffusion dynamics and are virtually undissociable. Furthermore, Jaks take an active role in the regulation of the surface expression of at least some cytokine receptors, including the OSMR and this may provide a quality control mechanism ensuring that only signalling-competent receptors (i.e. those with an associated Jak) would be enriched at the cell surface. [less ▲]

En Europe aussi, quels défis pour l’éducation?

Presentation (2006, November)

Die "Große Siechenbande" : Kriminalität unter dem Deckmantel der Armenfürsorge

Scientific Conference (2006, October 20)

On enumerating the kernels in a bipolar-valued digraph

in Annales du LAMSADE (2006), 6

In this paper we would like to thoroughly cover the problem of computing all kernels, i.e. minimal outranking and/or outranked independent choices in a bipolar- valued outranking digraph. First we ... [more ▼]

In this paper we would like to thoroughly cover the problem of computing all kernels, i.e. minimal outranking and/or outranked independent choices in a bipolar- valued outranking digraph. First we introduce in detail the concept of bipolar-valued characterisation of outranking digraphs, choices and kernels. In a second section we present and discuss several algorithms for enumerating the kernels in a crisp digraph. A third section will be concerned with extending these algorithms to bipolar-valued outranking digraphs. [less ▲]