Ästhetik und Kompositionsweise der Gruppe der Six. Studien zu ihrer Kammermusik aus den Jahren 1917-1921

Doctoral thesis (1996)

Sportliche Aktivität und Gesundheit - Forschungslage in Luxemburg

Scientific Conference (1996, November)

Voluntary saccadic eye movements: Effect of task repetition. A pet study

Poster (1996, November)

The nature of the starter unit for the rapamycin polyketide synthase

in Angewandte Chemie International Edition (1996), 35(19), 2249-2251

A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of ... [more ▼]

A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis. [less ▲]

Characterization of some aggregation functions stable for positive linear transformations

in Proc. 44th Meeting of the Eur. Working Group "Multiple Criteria Decision Aiding" (MCDA 44), Brussels, Belgium, Oct. 3-4, 1996 (1996, October)

This paper deals with the characterization of some classes of aggregation functions often used in multicriteria decision making problems. The common properties involved in these characterizations are ... [more ▼]

This paper deals with the characterization of some classes of aggregation functions often used in multicriteria decision making problems. The common properties involved in these characterizations are “increasing monotonicity” and “stability for positive linear transformations”. Additional algebraic properties related to associativity allow to completely specify the functions. [less ▲]

On computing kernels on fuzzy simple graphs by combinatorial enumeration using a CPL(FD) system

Scientific Conference (1996, September 09)

This paper reports our communication done at the 8th Benelux Workshop on Logic Programming in Louvain-la-Neuve, 9 September 1996. We present a constraint formulation in finite domains of the kernel ... [more ▼]

This paper reports our communication done at the 8th Benelux Workshop on Logic Programming in Louvain-la-Neuve, 9 September 1996. We present a constraint formulation in finite domains of the kernel construction on simple digraphs and give some comments on implementation in CHIP. Application to fuzzy choice procedures will illustrate the theoretical developments. [less ▲]

Der soziale Kontext sportlicher Aktivität - Eine Untersuchung an luxemburger und deutschen Jugendlichen

Scientific Conference (1996, September)

« Wir müssen lernen, mit Aggressionen umzugehen »

Article for general public (1996)

Die pschohygienische Funktion des Wert- und Religionsunterrichtes

Article for general public (1996)

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the genes flanking the polyketide synthase

in Gene (1996), 169(1), 1-7

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme ... [more ▼]

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round of polyketide chain extension. Detailed sequence comparison between these protein modules has allowed further characterisation of aa that may be important in catalysis or specificity. The acyl-carrier protein (ACP), beta-ketoacyl-ACP synthase (KS) and acyltransferase (AT) domains (the core domains) have an extremely high degree of mutual sequence homology. The KS domains in particular are almost perfect repeats over their entire length. Module 14 shows the least homology and is unique in possessing only core domains. The enoyl reductase (ER), beta-ketoacyl-ACP reductase (KR) and dehydratase (DH) domains are present even in certain modules where they are not apparently required. Four DH domains can be recognised as inactive by characteristic deletions in active site sequences, but for two others, and for KR and ER in module 3, the sequence is not distinguishable from that of active counterparts in other modules. The N terminus of RAPS1 contains a novel coenzyme A ligase (CL) domain that activates and attaches the shikimate-derived starter unit, and an ER activity that may modify the starter unit after attachment. The sequence comparison has revealed the surprisingly high sequence similarity between inter-domain 'linker' regions, and also a potential amphipathic helix at the N terminus of each multienzyme subunit which may promote dimerisation into active species. [less ▲]