![]() Education as risk factor of Mild Cognitive Impairment - the role of the gut microbiome. Presentation in symposium: Social determinants of brain health: From the search for mechanisms to recommendations to increase equityKlee, Matthias ; Aho, Velma ; May, Patrick et alScientific Conference (2023, November) Detailed reference viewed: 99 (1 UL) Migration and Health in Older Adults: The Cognitive and Health Profile of Lusophone Immigrants in Luxembourg in Comparison to Local Samples from Portugal; Teixeira Santos, Ana Carolina ; et alPoster (2023, September 04) Objective: This study aimed to investigate differences in cognition, mental health, and general health among older Lusophone immigrants (>55 years old) in Luxembourg compared to a sample residing in ... [more ▼] Objective: This study aimed to investigate differences in cognition, mental health, and general health among older Lusophone immigrants (>55 years old) in Luxembourg compared to a sample residing in Portugal. Methods: Data from immigrants (N=83, mean age=62.08, SD=6.511, 72.84% women) were sourced from the MEDITAGING study, funded by the Luxembourg National Research Fund (FNR)-Project Reference 15240063. Portuguese data were collected by the GABT (N=55, mean age=68.18, SD = 5.869, 74.55% women) and PREDICTOR projects (N=83, mean age=67.86, SD=5.24, 83.13% women). The outcomes were the Body Mass Index and the score on the Mini-Mental State Examination, the Trail Making Test (TMT), the 5-Item Geriatric Depression Scale (GDS-5), and the Geriatric Anxiety Scale (GAI). Results: The findings revealed significant differences between the immigrant and reference samples in TMT time A (p = .018), TMT time B (p = .004), TMT B-A (p = .03 0), GAI (p < .001), and GDS (p = .001), with immigrants performing higher than their peers in all these measures. A Linear regression analysis indicated that having hypertension (p = .026), being unmarried (p = .008), and having fewer years of formal education (p = .003) are associated with higher scores in TMT Time A, while having less formal education (p > .001) is related to higher scores in Time B. Conclusion: The findings suggest that Lusophone immigrants residing in Luxembourg have worse affective and cognitive outcomes compared to their peers living in Portugal. However, further exploration of the influence of health and sociodemographic factors is necessary. [less ▲] Detailed reference viewed: 88 (0 UL) Education as risk factor of Mild Cognitive Impairment - the role of the gut microbiomeKlee, Matthias ; Aho, Velma ; May, Patrick et alPoster (2023, July) Detailed reference viewed: 93 (4 UL) Wie lässt sich das individuelle Risiko für Demenz reduzieren? Neue Erkenntnisse aus der Demenz-PräventionsforschungLeist, Anja ![]() Scientific Conference (2023, June) Detailed reference viewed: 107 (1 UL) Gender inequalities as contributors to dementia in Latin America and the Caribbean: what factors are missing from research?Ribeiro, Fabiana ; ; Leist, Anja ![]() in The Lancet Healthy Longevity (2023) Detailed reference viewed: 115 (2 UL) Socioeconomic Deprivation, Genetic Risk, and Incident DementiaKlee, Matthias ; Leist, Anja ; et alin American Journal of Preventive Medicine (2023) Detailed reference viewed: 141 (2 UL) Modifiable risk factors for cognitive ageing and dementia. UniTalkLeist, Anja ![]() Presentation (2023, March 29) Detailed reference viewed: 99 (6 UL) Contributions of modifiable risk factors to increased dementia risk in depressionGeraets, Anouk ; Leist, Anja ; et alin Psychological Medicine (2023) Detailed reference viewed: 99 (5 UL) Sex/gender and socioeconomic differences in modifiable risk factors for dementiaGeraets, Anouk ; Leist, Anja ![]() in Scientific Reports (2023) Detailed reference viewed: 126 (4 UL) Education as risk factor of Mild Cognitive Impairment - the role of the gut microbiome.Klee, Matthias ; Aho, Velma ; May, Patrick et alPoster (2023, January) Detailed reference viewed: 73 (2 UL) Risk and protective factors for cognitive decline in lower educated older adults with 15-year follow-upRibeiro, Fabiana ; Leist, Anja ![]() Poster (2023) Detailed reference viewed: 69 (0 UL) Gendered life courses and cognitive functioning in later life: the role of context-specific gender norms and lifetime employment; Leist, Anja ![]() in European Journal of Ageing (2023) With increasing life expectancy, dementia poses an epidemiological challenge. As a cure has not been developed, the investigation into preventive factors becomes pivotal. Previous research emphasizes the ... [more ▼] With increasing life expectancy, dementia poses an epidemiological challenge. As a cure has not been developed, the investigation into preventive factors becomes pivotal. Previous research emphasizes the cognitively stimulating and socio-emotional benefits of lifetime employment, but research on heterogeneous patterns across social groups and societal contexts remains sparse. Sociological approaches have a promising potential to provide insights into health inequalities and can contribute to the study of this major societal challenge. We investigate the influence of previous employment biographies on cognitive functioning for men and women aged 50 to 75 in 19 European countries, using longitudinal and retrospective information from the Survey of Health, Ageing and Retirement in Europe. We link individual information on employment biographies and cognitive functioning to contextual measures of gender norms, using aggregated agreement rates to both men's and women's role in employment and family. We find that previous employment affects cognitive functioning men and women differently. Part-time employment is beneficial for women's cognitive functioning, but not for men's. Traditional gender norms are associated with lower levels of cognitive functioning for both genders and moderate the linkage between previous employment and cognitive functioning. In contexts with more traditional gender norms, men's part-time employment is associated with lower and women's part-time employment with higher cognitive functioning. We conclude that employment and non-employment participation can, depending on characteristics of individuals and contexts, benefit or hinder the life-course accumulation of cognitive reserve, and those with norm-deviating behaviour are disadvantaged. [less ▲] Detailed reference viewed: 218 (3 UL) Validation of a Parkinson's disease questionnaire-39-based functional mobility composite score (FMCS) in people with Parkinson's disease.Hanff, Anne-Marie ; ; Rauschenberger, Armin et alin Parkinsonism & related disorders (2023), 112 INTRODUCTION: Functional mobility is an important outcome for people with Parkinson's disease (PwP). Despite this, there is no established patient-reported outcome measure that serves as a gold standard ... [more ▼] INTRODUCTION: Functional mobility is an important outcome for people with Parkinson's disease (PwP). Despite this, there is no established patient-reported outcome measure that serves as a gold standard for assessing patient-reported functional mobility in PwP. We aimed to validate the algorithm calculating the Parkinson's Disease Questionnaire-39 (PDQ-39) based Functional Mobility Composite Score (FMCS). METHODS: We designed a count-based algorithm to measure patient-reported functional mobility in PwP from items of the PDQ-39 subscales mobility and activities of daily living. Convergent validity of the algorithm calculating the PDQ-39-based FMCS was assessed using the objective Timed Up and Go (n = 253) and discriminative validity was assessed by comparing the FMCS with patient-reported (MDS-UPDRS II) and clinician-assessed (MDS-UPDRS III) motor symptoms as well as between disease stages (H&Y) and PIGD phenotypes (n = 736). Participants were between 22 and 92 years old, with a disease duration from 0 to 32 years and 64.9% in a H&Y 1-2 ranging from 1 to 5. RESULTS: Spearman correlation coefficients (r(s)) ranging from -0.45 to -0.77 (p < 0.001) indicated convergent validity. Hence, a t-test suggested sufficient ability of the FMCS to discriminate (p < 0.001) between patient-reported and clinician-assessed motor symptoms. More specifically, FMCS was more strongly associated with patient-reported MDS-UPDRS II (r(s) = -0.77) than clinician-reported MDS-UPDRS III (r(s) = -0.45) and can discriminate between disease stages as between PIGD phenotypes (p < 0.001). CONCLUSION: The FMCS is a valid composite score to assess functional mobility through patient reports in PwP for studying functional mobility in studies using the PDQ-39. [less ▲] Detailed reference viewed: 115 (1 UL) Prevalence of dementia in Latin America and Caribbean countries: Systematic review and meta-analyses exploring age, sex, rurality, and education as possible determinantsRibeiro, Fabiana ; Teixeira Santos, Ana Carolina ; et alin Ageing Research Reviews (2022) Background Studies have shown that the prevalence of dementia in Latin America and the Caribbean (LAC) may be higher than in high-income countries. Thus, we sought to systematically analyse the prevalence ... [more ▼] Background Studies have shown that the prevalence of dementia in Latin America and the Caribbean (LAC) may be higher than in high-income countries. Thus, we sought to systematically analyse the prevalence of dementia and explore possible drivers that lead to this disparity in LAC countries. Method We searched Pubmed, Web of Knowledge, Scopus, Lilacs, and SciELO for studies on dementia in LAC countries published in English, Spanish, and Portuguese. Random-effects model was applied. Results Thirty-one studies from 17 LAC countries were included. Pooled prevalence of all-cause dementia was 10.66%. Further analyses with studies providing raw prevalence by sex, area, and educational level showed a higher prevalence for women (8.97%) than for men (7.26%). Also, dementia prevalence was higher for rural than urban residents (7.71% vs 8.68%, respectively). Participants without formal education presented more than double the prevalence of dementia (21.37%) compared to those with at least one year of formal education (9.88%). Studies with more recent data collection showed higher dementia prevalence. Conclusion Our findings suggest a high global dementia prevalence in LAC countries and an unequal burden of dementia for women, lower-educated, and rural residents. Secular increases in dementia prevalence call for greater public health efforts for preventative actions. [less ▲] Detailed reference viewed: 86 (0 UL) PRELIMINARY RESULTS ON THE COGNITIVE PROFILE IN PRODROMAL PARKINSON’S DISEASE – A PROSPECTIVE STUDY Pauly, Laure ; Hansen, Maxime ; et alPoster (2022, September) Detailed reference viewed: 78 (1 UL) Country-Level Availability and Generosity of Healthcare Services, and Ageism’s Effects upon COVID-19 Era Missed HealthcareSettels, Jason ; Leist, Anja ![]() Scientific Conference (2022, August 08) Detailed reference viewed: 93 (4 UL) Country-level Variation of Dementia Prevalence in Europe - Comparing OECD and SHARE DataKlee, Matthias ; ; Leist, Anja ![]() Presentation (2022, July 07) Detailed reference viewed: 155 (9 UL) Why should we discuss gender inequalities in Latin America and their effects in later life? Ribeiro, Fabiana ; Leist, Anja ![]() Presentation (2022, June 08) Detailed reference viewed: 61 (0 UL) Childhood socioeconomic disadvantage and pathways to memory performance in mid to late adulthood: What matters most?Ford, Katherine Joy ; ; Leist, Anja ![]() in Journals of Gerontology. Series B, Psychological Sciences and Social Sciences (2022), 77(8), 14781489 Objectives. Childhood socioeconomic disadvantage is consistently associated with lower cognitive function in later life. This study aims to distinguish the contribution of specific aspects of childhood ... [more ▼] Objectives. Childhood socioeconomic disadvantage is consistently associated with lower cognitive function in later life. This study aims to distinguish the contribution of specific aspects of childhood socioeconomic disadvantage for memory performance in mid to late adulthood, with consideration for direct and indirect effects through education and occupation. Methods. Data were from adults aged 50 to 80 years who completed the life history module in the 2006/2007 wave of the English Longitudinal Study of Aging (n = 4,553). The outcome, memory score, was based on word recall tests (range: 0–20 points). We used the g-formula to estimate direct and indirect effects of a composite variable for childhood socioeconomic disadvantage and its 4 individual components: lower-skilled occupation of the primary breadwinner, having few books in the home, overcrowding in the home, and lack of water and heating facilities in the home. Results. Few books were the most consequential component of childhood socioeconomic disadvantage for later-life memory (total effect: −0.82 points for few books; 95% confidence interval [CI]: −1.04, −0.60), with roughly half being a direct effect. The total effect of a breadwinner in lower-skilled occupations was smaller but not significantly different from a few books (−0.67 points; 95% CI: −0.88, −0.46), while it was significantly smaller with overcrowding (−0.31 points; 95% CI: −0.56, −0.06). The latter 2 total effects were mostly mediated by education and occupation. Discussion. A literate environment in the childhood home may have lasting direct effects on memory function in mid to later life, while parental occupation and overcrowding appear to influence memory primarily through educational and occupational pathways. [less ▲] Detailed reference viewed: 61 (0 UL) Machine learning in Public Health: Relevant applications in ageing populationsLeist, Anja ![]() Presentation (2022, April 25) Detailed reference viewed: 125 (3 UL) |
||