References of "Hachi, Siham 50001919"
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See detailAUTOMATED CALCIUM IMAGE ANALYSIS OF NEURONS DERIVED FROM PLURIPOTENT STEM CELLS
Hachi, Siham UL

Doctoral thesis (2018)

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See detailDerivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Monzel, Anna Sophia UL; Smits, Lisa UL; Hemmer, Kathrin UL et al

in Stem Cell Reports (2017)

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See detailAutomated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease
Kane, Khalid UL; Lucumi Moreno, Edinson UL; Hachi, Siham UL et al

in bioRxiv (2017)

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See detailDifferentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture
Lucumi Moreno, Edinson UL; Hachi, Siham UL; Hemmer, Kathrin UL et al

in Lab on a Chip - Miniaturisation for Chemistry and Biology (2015), 15

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See detailA constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
Mao, Longfei UL; Nicolae, Averina UL; Oliveira, Miguel UL et al

in Computational and Structural Biotechnology Journal (2015), 13

Abstract One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not ... [more ▼]

Abstract One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease. [less ▲]

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