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See detailA co-located partitions strategy for parallel CFD-DEM couplings
Pozzetti, Gabriele UL; Besseron, Xavier UL; Rousset, Alban UL et al

E-print/Working paper (in press)

In this work, a new partition-collocation strategy for the parallel execution of CFD–DEM couplings is investigated. Having a good parallel performance is a key issue for an Eulerian-Lagrangian software ... [more ▼]

In this work, a new partition-collocation strategy for the parallel execution of CFD–DEM couplings is investigated. Having a good parallel performance is a key issue for an Eulerian-Lagrangian software that aims to be applied to solve industrially significant problems, as the computational cost of these couplings is one of their main drawback. The approach presented here consists in co-locating the overlapping parts of the simulation domain of each software on the same MPI process, in order to reduce the cost of the data exchanges. It is shown how this strategy allows reducing memory consumption and inter-process communication between CFD and DEM to a minimum and therefore to overcome an important parallelization bottleneck identified in the literature. Three benchmarks are proposed to assess the consistency and scalability of this approach. A coupled execution on 280 cores shows that less than 0.1% of the time is used to perform inter-physics data exchange. [less ▲]

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See detailTUNA: TUning Naturalness-based Analysis
Jimenez, Matthieu UL; Cordy, Maxime UL; Le Traon, Yves UL et al

in 34th IEEE International Conference on Software Maintenance and Evolution, Madrid, Spain, 26-28 September 2018 (2018, September 26)

Natural language processing techniques, in particular n-gram models, have been applied successfully to facilitate a number of software engineering tasks. However, in our related ICSME ’18 paper, we have ... [more ▼]

Natural language processing techniques, in particular n-gram models, have been applied successfully to facilitate a number of software engineering tasks. However, in our related ICSME ’18 paper, we have shown that the conclusions of a study can drastically change with respect to how the code is tokenized and how the used n-gram model is parameterized. These choices are thus of utmost importance, and one must carefully make them. To show this and allow the community to benefit from our work, we have developed TUNA (TUning Naturalness-based Analysis), a Java software artifact to perform naturalness-based analyses of source code. To the best of our knowledge, TUNA is the first open- source, end-to-end toolchain to carry out source code analyses based on naturalness. [less ▲]

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See detailOn the impact of tokenizer and parameters on N-gram based Code Analysis
Jimenez, Matthieu UL; Cordy, Maxime UL; Le Traon, Yves UL et al

Scientific Conference (2018, September)

Recent research shows that language models, such as n-gram models, are useful at a wide variety of software engineering tasks, e.g., code completion, bug identification, code summarisation, etc. However ... [more ▼]

Recent research shows that language models, such as n-gram models, are useful at a wide variety of software engineering tasks, e.g., code completion, bug identification, code summarisation, etc. However, such models require the appropriate set of numerous parameters. Moreover, the different ways one can read code essentially yield different models (based on the different sequences of tokens). In this paper, we focus on n- gram models and evaluate how the use of tokenizers, smoothing, unknown threshold and n values impact the predicting ability of these models. Thus, we compare the use of multiple tokenizers and sets of different parameters (smoothing, unknown threshold and n values) with the aim of identifying the most appropriate combinations. Our results show that the Modified Kneser-Ney smoothing technique performs best, while n values are depended on the choice of the tokenizer, with values 4 or 5 offering a good trade-off between entropy and computation time. Interestingly, we find that tokenizers treating the code as simple text are the most robust ones. Finally, we demonstrate that the differences between the tokenizers are of practical importance and have the potential of changing the conclusions of a given experiment. [less ▲]

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See detailA decision support system for energy saving in Waste Water Treatment Plants
Torregrossa, Dario UL

Doctoral thesis (2018)

Waste Water Treatment Plants (WWTPs) are complex facilities, in which an efficient energy management can produce relevant benefits for the environment and the economy. Today, big data can be used for a ... [more ▼]

Waste Water Treatment Plants (WWTPs) are complex facilities, in which an efficient energy management can produce relevant benefits for the environment and the economy. Today, big data can be used for a more efficient plant management, enabling high-frequency assessment and ultimately a more efficient use of resources. In order to achieve this, a computer-based support is necessary to analyse the enormous amount of data that WWTP sensors can produce. When this PhD project started, the literature review showed that, in the WWTP domain, the few available decision support systems (DSSs) were promising but still with large room for improvements; in fact, these tools were plant-specific, focussed mainly on process parameters and (most of them) working with low-frequency aggregated data (yearly data). This thesis instead proposes a cooperative decision support system called Shared Knowledge Decision Support System (SK-DSS). SK-DSS is plant generic, i.e. able to simultaneously work with many WWTPs and based on key performance indicators. SK-DSS analyses the processes occurring in the plants and provide case-based solutions. Moreover, this DSS provides a platform to enable the plant managers to exchange information and cooperate. This thesis proposes the model of SK-DSS, a web-application, and applications to improve the energy performance of pump, blowers and biogas. [less ▲]

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See detailActivity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
Jan, Asad; Jansonius, Brandon; Delaidelli, Alberto et al

in Acta Neuropathologica Communications (2018)

Detailed reference viewed: 30 (3 UL)
See detailCross-border vocational education and training as a process of cross-border learning. The example of the Saarland-Lorraine border region
Funk, Ines; Nienaber, Birte UL; Dörrenbächer, H. Peter

Scientific Conference (2018)

Detailed reference viewed: 11 (0 UL)
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See detailTHE PARKINSON’S DISEASE ASSOCIATED PINK1-PARKIN PATHWAY IN PATHOLOGY AND DEVELOPMENT
Jarazo, Javier UL

Doctoral thesis (2018)

Parkinson’s disease (PD) has an aetiology not completely understood. One of the hypothesis in the field is that many neurodegenerative diseases are influenced by developmental disorders. The underlying ... [more ▼]

Parkinson’s disease (PD) has an aetiology not completely understood. One of the hypothesis in the field is that many neurodegenerative diseases are influenced by developmental disorders. The underlying concept is that already during brain development some processes are deregulated producing a higher degree of susceptibility for neurodegeneration during aging. Two hereditary early onset forms of PD are caused by recessive mutations in PTEN-induced putative kinase 1 (PINK1) and Parkin genes that regulate mitochondrial function and morphology, quarantining damaged mitochondria before their degradation as well as triggering the process of mitophagy. Our hypothesis is that alterations of the Pink1-Parkin pathway have an impact in mitochondrial physiology tempering the differentiation ability of neuroepithelial stem cells into dopaminergic neurons. For evaluating this hypothesis we reprogramed patients’ fibroblasts carrying PINK1 mutations, as well as from healthy individuals, to human induced pluripotent stem cells. We developed a streamlined technique of gene editing (FACE) by using the CRISPR/Cas9 system combined with a composite of fluorescent proteins in the donor template for biallelic gene targeting. Isogenic controls were generated using this technique that allowed us to analyze the contribution of corrected patients’ mutations in the cellular defects observed. Human iPSCs were differentiated into a neuroepithelial stem cell state (NESC) from where the cells were further differentiated into neurons. We established different algorithms for pattern recognition and applied them for image analysis of different features such as mitochondrial morphology, proliferation capacity, apoptosis and differentiation. Patient’s derived cells presented an impaired differentiation efficiency into dopaminergic neurons as well as an imbalanced cell renewal that can be linked to the mitochondrial differences. Using 3D cultures, such as microfluidics and organoids, we were able to recapitulate this differentiation impairment in a system that mimics better the context of an in vivo environment. We evaluated the energetic capabilities of the NESCs and the firing activity of differentiated neurons, which also showed a dysregulation in patient cells. We introduced a new system for large-scale analysis of the autophagy and mitophagy pathways by the combination of stably integrated Rosella constructs in different patients’ lines and an image analysis script for classification of the different subcellular structures involved in these pathways activities. This revealed that the basal activity as well as the response against stressors of these pathways are altered in cells derived from patients having different mutations causative of PD. We performed a screen of repurposed drugs as well as of novel compounds to evaluate their impact in this altered developmental transition identifying a potential candidate to be further analysed in an in vivo context. [less ▲]

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See detailLa rhétorique communicationnelle en droit judiciaire européen
Menetrey, Séverine UL

in La concurrence des juges en Europe (2018)

Detailed reference viewed: 26 (1 UL)
See detailLa nature juridique de l’enrôlement
Menetrey, Séverine UL

in Pasicrisie Luxembourgeoise : Recueil Trimestriel de la Jurisprudence Luxembourgeoise (2018)

Detailed reference viewed: 23 (1 UL)
See detailMesures d’instruction
Menetrey, Séverine UL

in Jurisclasseur Procédure Civile (2017)

Detailed reference viewed: 7 (0 UL)