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See detailFrom Network Analysis to Functional Metabolic Modeling of the Human Gut Microbiota
Bauer, Eugen; Thiele, Ines UL

in mSystems (2018)

An important hallmark of the human gut microbiota is its species diversity and complexity. Various diseases have been associated with a decreased diversity leading to reduced metabolic functionalities ... [more ▼]

An important hallmark of the human gut microbiota is its species diversity and complexity. Various diseases have been associated with a decreased diversity leading to reduced metabolic functionalities. Common approaches to investigate the human microbiota include high-throughput sequencing with subsequent correlative analyses. However, to understand the ecology of the human gut microbiota and consequently design novel treatments for diseases, it is important to represent the different interactions between microbes with their associated metabolites. Computational systems biology approaches can give further mechanistic insights by constructing data- or knowledge-driven networks that represent microbe interactions. In this minireview, we will discuss current approaches in systems biology to analyze the human gut microbiota, with a particular focus on constraint-based modeling. We will discuss various community modeling techniques with their advantages and differences, as well as their application to predict the metabolic mechanisms of intestinal microbial communities. Finally, we will discuss future perspectives and current challenges of simulating realistic and comprehensive models of the human gut microbiota. [less ▲]

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See detailArithmetic billiards
Perucca, Antonella UL

Article for general public (2018)

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See detailModeling metabolism of the human gut microbiome
Magnusdottir, Stefania UL; Thiele, Ines UL

in Current Opinion in Biotechnology (2018)

The human gut microbiome plays an important part in human health. The complexity of the microbiome makes it difficult to determine the detailed metabolic functions and cross-talk occurs between the ... [more ▼]

The human gut microbiome plays an important part in human health. The complexity of the microbiome makes it difficult to determine the detailed metabolic functions and cross-talk occurs between the individual species. In silico systems biology studies of the microbiome can help to identify metabolite exchanges among gut microbes. Constraint-based reconstruction and analysis methods use biochemically accurate genome-scale metabolic networks of microorganisms to simulate metabolism between species in a given microbiome and help generate novel hypotheses on microbial interactions. Here, we review metabolic modeling studies that have investigated metabolic functions of the gut microbiome. [less ▲]

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See detailLocal curvature estimates for the Laplacian flow
Li, Yi UL

E-print/Working paper (2018)

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See detailDetecting Malicious Authentication Events Trustfully
Kaiafas, Georgios UL; Varisteas, Georgios UL; Lagraa, Sofiane UL et al

in Kaiafas, Georgios; Varisteas, Georgios; Lagraa, Sofiane (Eds.) et al IEEE/IFIP Network Operations and Management Symposium, 23-27 April 2018, Taipei, Taiwan Cognitive Management in a Cyber World (2018)

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See detailIntegrated Protection of Industrial Control Systems from Cyber-attacks: the ATENA Approach
Adamsky, Florian UL; Aubigny, Matthieu; Battisti, Federica et al

in Elsevier International Journal of Critical Infrastructure Protection (2018)

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See detailMachine Learning for Reliable Network Attack Detection in SCADA Systems
Lopez Perez, Rocio; Adamsky, Florian UL; Soua, Ridha UL et al

in 17th IEEE International Conference On Trust, Security And Privacy In Computing And Communications (IEEE TrustCom-18) (2018)

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See detailSignaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells
Medelnik, Jan-Philip; Roensch, Kathleen; Okawa, Satoshi UL et al

in Stem Cell Reports (2018)

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See detailLa désinstutionnalisation psychiatrique. Un phénomène introuvable en Belgique dans les années 1960 et 1970?
Majerus, Benoît UL

in Guillemain, Hervé; Klein, Alexandre; Thifault, Marie-Claude (Eds.) Fin de l’asile ?: histoire de la déshospitalisation psychiatrique dans l’espace francophone au XXe siècle (2018)

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See detailL’enseignement du chinois standard en tant que 3ème ou 4ème langue étrangère dans une classe de seconde en Alsace : le rôle de la notion de compétence plurilingue et pluriculturelle
Chen, Yan-Zhen UL

Doctoral thesis (2017)

This thesis consists of a qualitative and ethnographic research. It aims to determinate the role played by the plurilingual and pluricultural competence of a teacher and her twenty-two full beginner ... [more ▼]

This thesis consists of a qualitative and ethnographic research. It aims to determinate the role played by the plurilingual and pluricultural competence of a teacher and her twenty-two full beginner students in the context of the teaching of Chinese as a foreign language. How does this teacher interpret this notion? How can this teacher take into account and make use of her students’ previously acquired languages, i.e. their plurilingual repertoire, to facilitate her teaching? This thesis concerns not only identifying the mechanisms and the frequency of the use of the plurilingual repertoire in the teaching of standard Chinese, but also interrogating the teacher and the students’ representation. This analysis intends to seize the causes of the gap between the official discourse and instructions on one hand and the empirical teaching and learning practices on the other hand. This thesis demonstrated two significant results: the “sloganization” of the notion of plurilingual and pluricultural competence in French educative language policies and the lack of awareness of the protagonists concerning their solicitation of the plurilingual and pluricultural competence in the classroom. [less ▲]

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See detailRapport politique sur les migrations et l'asile (2016)
Petry, David UL; Jacobs, Sarah UL; Nienaber, Birte UL

Report (2017)

Le présent rapport fait la synthèse des principaux débats et des évolutions concernant l’immigration et l’asile au Luxembourg en 2016. Au cours de cette année, quatre sujets ont dominé les discussions ... [more ▼]

Le présent rapport fait la synthèse des principaux débats et des évolutions concernant l’immigration et l’asile au Luxembourg en 2016. Au cours de cette année, quatre sujets ont dominé les discussions publiques et politiques : l’organisation de l’accueil, ainsi que les mesures de soutien et d’intégration, en lien avec l’afflux continu de demandeurs de protection internationale (DPI) en 2016, la réforme de la loi sur la nationalité luxembourgeoise, la migration économique, et les mesures prises ou envisagées pour adapter l’éducation formelle et informelle à l’hétérogénéité croissante de la population luxembourgeoise. Le débat sur la protection internationale soulevé en 2015 s’est poursuivi en 2016, en se concentrant cette fois-ci sur les mesures d’accueil, de soutien et d’intégration. L’afflux de DPI demeurant relativement élevé en 2016 avec 2 043 demandes, l’Office luxembourgeois de l’accueil et de l’intégration (OLAI) n’a cessé, tout au long de l’année, de mettre l’accent sur le fait que les structures du pays atteindraient prochainement les limites de leur capacité d’accueil. Les difficultés que rencontrent les bénéficiaires de protection internationale (BPI) pour trouver un logement approprié et la contestation tant populaire que judiciaire des résidents locaux pour contrer les projets de construction de nouveaux foyers d’accueil, ont donné lieu à des débats à grande échelle auxquels ont participé le public, les médias ainsi que la société civile et les acteurs politiques. L’afflux continu de DPI a également exercé des pressions sur les administrations concernées, aussi bien en termes de ressources financières que de ressources humaines, et ont entraîné des discussions sur la longueur des procédures et les variations de ces délais. L’accueil des DPI et l’intégration des BPI est devenu un défi important alors que le nouveau profil des personnes entrant au Luxembourg a induit de nouveaux enjeux en termes d’apprentissage de la langue et d’éducation des nouveaux arrivants et dans l’ensemble, a souligné la nécessité d’adapter les mesures de soutien existantes et d’en créer de nouvelles pour les bénéficiaires et les demandeurs. Parallèlement, le rôle des organisations non gouvernementales en matière de soutien du Gouvernement dans le cadre de l’accueil des demandeurs et de mise en place de nouveaux projets venant faciliter leur intégration, a également pris de l’ampleur en 2016, notamment du fait des plus de 80 projets financés par l’Œuvre Nationale de Secours Grande Duchesse Charlotte (ci-après l’Œuvre). De nouveaux acteurs sont apparus sur la scène publique avec l’instauration du Centre luxembourgeois pour l’intégration et la cohésion sociale (LISKO) de la Croix Rouge conventionné par le ministère de la Famille, de l’Intégration et à la Grande Région, qui a pour objet de promouvoir l’intégration des BPI au sein de la société luxembourgeoise, en privilégiant l’accès au logement. Toujours, sur le plan de la protection internationale, le Luxembourg a poursuivi les engagements pris en 2015 en matière de réinstallation et de relocalisation, 167 personnes ayant été relocalisées de Grèce et d’Italie vers le Luxembourg et 52 ayant été réinstallées dans le cadre de la Déclaration UE-Turquie en 2016. La lutte contre la traite des êtres humains (TEH) était un autre sujet de préoccupation important en 2016. Le Conseil de gouvernement a adopté le Plan d’action national sur la traite des êtres humains qui comprend des mesures relatives à la détection et la protection des victimes, la poursuite judiciaire et les sanctions imposées aux auteurs et qui vise la mise en place d’une politique active et efficace de lutte contre la traite. La stratégie du Luxembourg sur la prostitution a été présentée : elle consiste en un Plan d’action national sur la prostitution et en un projet de loi qui renforce la lutte contre l’exploitation de la prostitution, le proxénétisme et la traite des êtres humains. De plus, le rapporteur national, la Commission Consultative des Droits de l’Homme (CCDH) a publié son premier rapport sur la traite des êtres humains, qui couvre les années 2014 à 2016. L’adaptation de la législation luxembourgeoise dans le domaine de la migration légale a également pris forme en 2016, bien que suscitant moins d’intérêt et de débat public. Avec l’introduction d’un projet de loi, le législateur a lancé le processus de transposition de la Directive 2014/36/UE sur les travailleurs saisonniers et de la Directive 2014/66/UE sur les transferts temporaires intra-groupe en droit national. Ce même projet de loi a également introduit une autorisation de séjour destinée aux investisseurs et un mécanisme de continuité d’activité, a détaillé les conditions dans lesquelles un mandataire social ressortissant d’un pays tiers (RPT) pouvait demander une autorisation de séjour, a prolongé la période de validité du titre de séjour « Carte bleue européenne », a modifié les dispositions concernant le changement du statut des étudiants et a facilité le regroupement familial. Ces évolutions sont à situer dans un contexte plus large de diversification économique, d’incitation à l’entreprenariat et de repositionnement du centre financier. Dans le domaine de la migration et du développement, le Luxembourg a continué de mettre l’accent sur les formations professionnelles et les projets d’intégration dans ses programmes indicatifs de coopération avec les pays partenaires. Par ailleurs, le Conseil de gouvernement a approuvé le projet de loi sur l’accord entre le Grand-Duché de Luxembourg et la République du Cap-Vert sur la gestion concertée des flux migratoires et le développement solidaire facilitant la circulation des personnes et visant à encourager la migration professionnelle circulaire temporaire entre le Luxembourg et le CapVert. Sur le plan du retour des migrants en situation irrégulière ou sans droit de séjour il convient de mentionner l’exclusion des ressortissants du Kosovo du programme AVRRL, le processus d’évaluation Schengen et les changements qui en résultent sur les dispositions en matière de rétention : L’extension prévue de la période maximale de rétention pour les familles avec enfants et pour les mineurs non accompagnés (MNA) qui devait passer de 72 heures à 7 jours, a suscité de vives réactions de la part de la société civile. La mise en œuvre de la Déclaration UE-Afghanistan « Joint Way Forward on migration issues », ainsi que la poursuite de l’élaboration des accords de réadmission ont constitué d’autres aspects importants de la politique migratoire. Sur le plan des politiques d’intégration, le projet de réforme de la loi sur la nationalité luxembourgeoise a été considéré comme moyen important pour lutter contre le déficit démocratique croissant du Luxembourg suite au refus des électeurs d’accorder le droit de vote aux résidents étrangers pour les législatives lors du référendum de 2015. Avec ce projet de réforme a été relancé le perpétuel débat sur les langues au Luxembourg, en particulier sur le rôle et le statut de la langue luxembourgeoise et son lien avec l’intégration des migrants au sein de la société luxembourgeoise. Afin de renforcer la participation des résidents étrangers aux prochaines élections municipales du mois d’octobre 2017, le Gouvernement a lancé une campagne de sensibilisation, pour encourager les résidents étrangers à s’inscrire sur les listes électorales. Le ministère de l’Education nationale, de l’Enfance et de la Jeunesse s’est efforcé de trouver des réponses à l’hétérogénéité croissante de la population luxembourgeoise, en visant à diversifier et à élargir l’offre d’enseignement, à développer l’éducation non formelle et l’éducation plurilingue dans les crèches dans le but de promouvoir l’intégration et l’égalité des chances. La transposition de la Directive 2013/55/UE sur la reconnaissance des qualifications professionnelles a également été menée à bien en 2016. La loi a modifié plusieurs dispositions nationales, et regroupé toutes les dispositions applicables en un seul texte législatif tout en simplifiant la procédure de reconnaissance. [less ▲]

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See detailPolicy Report on Migration and Asylum (2016)
Petry, David UL; Jacobs, Sarah UL; Nienaber, Birte UL

Report (2017)

The present report provides an overview of the main debates and developments in relation to migration and asylum in Luxembourg in 2016. The issue of migration remained on the forefront of public and ... [more ▼]

The present report provides an overview of the main debates and developments in relation to migration and asylum in Luxembourg in 2016. The issue of migration remained on the forefront of public and political debate, a debate axed on both planned legislative changes as well as the concrete migratory situation in Luxembourg. Four topics dominated public and policy discussions over the course of the year: the reform on Luxembourgish nationality, economic migration, the organisation of reception, as well as support and integration measures, linked to the continued inflow of applicants for international protection (AIPs) in 2016 and steps taken to adapt formal and informal education to the increasing heterogeneity of Luxembourg’s population. The debate on international protection that arose in 2015 was carried onward in 2016, the focus shifting towards reception, support and integration measures. As the inflow of AIPs remained relatively high in 2016 with 2.043 applications, Luxembourg’s Reception and Integration Agency (OLAI) warned throughout the year that the country’s structures would soon reach the limits of their capacity. Linked to the high recognition rate, the legal challenges that local residents put to the plans for the construction of new reception facilities and the difficulty of beneficiaries of international protection (BIPs) in finding appropriate accommodation, the perceived dearth of housing was discussed broadly by the public, the media, as well as civil society and political actors. The continued inflow of AIPs also put a strain on the concerned administrations, both in terms of financial and human resources, leading to discussions regarding the duration of procedures and the variations of this duration. Moreover, the question of integration or support measures for beneficiaries and applicants stepped to the forefront: the changed profile of people arriving in Luxembourg posed new challenges to language learning and education for the newly arrived, and overall, emphasised the need to adapt existing and create new integration and support measures for beneficiaries and applicants. At the same time, the role of non-governmental organisations in supporting the government in the reception of applicants and in establishing new projects facilitating their integration also grew over the course of 2016, not least due to over 80 projects being granted funding by the Oeuvre Nationale de Secours Grande Duchesse Charlotte (henceforth Oeuvre). The Luxembourgish Centre for Integration and Social Cohesion (LISKO), part of the Red Cross and supported by convention to the Ministry for Family and Integration opened its doors in April 2016. The newly created centre will take care of the integration of BIPs into Luxembourg’s society, putting its emphasis on facilitating access to housing. The planned extension of the maximum period of detention for families with children and unaccompanied minors (UAMs) from 72 hours to 7 days precipitated strong reactions from civil society and the public. Luxembourg furthermore followed through on its resettlement and relocation commitments made in 2015, with 167 persons being relocated from Greece and Italy to Luxembourg and with 52 being resettled in the context of the EU-Turkey agreement over the course of 2016. The adaptation of Luxembourg’s legislation in the domain of legal migration also took shape over in 2016 and was broadly debated during the law-making process, while warranting less public attention. With the introduction of one bill, the legislator started the process of transposing Directive 2014/36/EU on seasonal workers and Directive 2014/66/EU on intra-corporate transfers into national law. The same bill furthermore introduced an authorisation of stay for investors, the aspect most commented on by civil society; a mechanism for continuation of activity; detailed the conditions under which a TCN (third country national) corporate officer (mandataire social) can apply for an authorisation of stay, extended the period of validity of the "European Blue Card" residence permit from two to four years, modified dispositions regarding the change of status of students and facilitated family reunification. These developments are to be framed within a wider context of economic diversification, encouragement of entrepreneurship and the repositioning of the financial centre. The reform of the Luxembourgish nationality, another major subject of discussion, was recognised as the best way to counteract Luxembourg’s increasing democratic deficit after the electorate’s refusal to extend legislative voting rights to foreign residents, decided in the referendum of 2015. This reform further proceeded over the course of 2016, reintroduced the perennial language debate in Luxembourg, a larger debate on the role and status of the Luxembourgish language as well as its relation to integration of migrants into Luxembourgish society. In order to increase foreign residents’ participation in the upcoming municipal elections of October 2017, the government launched an awareness campaign encouraging foreign residents to register on the electoral roll, and provided support for organisations wishing to organise complementary actions. The Ministry of National Education and Youth made efforts to find responses to the growing heterogeneity of Luxembourg’s population, aiming to diversify and broaden the post-primary school offer, to develop plurilingual education in nurseries and to develop non-formal education by reforming in-kind benefits, this with the aim of promoting integration and equal opportunity. The transposition of Directive 2013/55/EU on the recognition of professional qualifications was also completed in 2016. The law further amended several national provisions, recast the legislation in the field of recognition of diplomas, combined all applicable provisions in a single legislative text and simplified the procedure for recognition. The debate regarding the return of irregular migrants circled around a number of issues in 2016: the exclusion of Kosovar nationals from the AVRRL programme, the Schengen evaluation and the aforementioned resulting changes to provisions on detention, the debate on the enforcement of the EU-Afghanistan ‘Joint way forward on migration issues’ agreement, as well as the continuation of the elaboration of readmission agreements. Luxembourg’s government took further steps in the fight against trafficking in human beings (THB) over the course of 2016. The Council of Government adopted the National Action Plan on trafficking in human beings, which focuses on the detection and protection of victims, the prosecution and punishment of perpetrators and a policy to combat trafficking. Luxembourg’s strategy on prostitution was presented, consisting of a National Action Plan on prostitution and a bill strengthening the fight against the exploitation of prostitution, procuring and THB. Additionally, the Consultative Commission on Human Rights (Commission Consultative des Droits de l’Homme – CCDH) published its first report on THB, which reviewed the years 2014-2016. In reference to migration and development, Luxembourg continued putting emphasis on vocational training and integration programmes in its indicative cooperation programmes with partner countries. Additionally, the Council of Government approved the bill on the agreement between the Grand Duchy of Luxembourg and the Republic of Cape Verde on the concerted management of migratory flows and solidarity-based development, facilitating the movement of persons and to encourage temporary circular professional migration between Luxembourg and Cape Verde. [less ▲]

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See detailCompte rendu de Sebastian Bischoff/Christoph Jahr/Tatjana Mrowka/Jens Thiel (Hrsg.): Belgica terra incognita? Resultate und Perspektiven der Historischen Belgienforschung
Brüll, Christoph UL

in Journal of Belgian History = Revue Belge d'Histoire Contemporaine = Belgisch Tijdschrift voor Nieuwste Geschiedenis (2017), 48(2/3), 259-262

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See detailDe Société de Médecine Mentale de Belgique in transnationaal perspectief (1869-1900)
Andersen, Eva UL

in Journal of Belgian History = Revue Belge d'Histoire Contemporaine = Belgisch Tijdschrift voor Nieuwste Geschiedenis (2017), 47(4),

The Société de Médecine Mentale de Belgique (SMMB) was created in the 19 th century. This society united the Belgian psychiatrists, made knowledge sharing possible and raised awareness of problems in the ... [more ▼]

The Société de Médecine Mentale de Belgique (SMMB) was created in the 19 th century. This society united the Belgian psychiatrists, made knowledge sharing possible and raised awareness of problems in the Belgian psychiatric world. During the meetings of the society, ideas and opinions of Belgian physicians as well as their foreign colleagues, were exchanged. Until now, research on these transnational contacts, particularly in Belgium, had been very superficial. Yet, the 19th century did not only see the advent of the nation, but also of more and more transnational networks. This article aspires to fill this void by focusing on the international profiling of the SMMB and by studying the impact of foreign alienists on Belgian psychiatry. To gain scientific status in Belgium as well as abroad, the SMMB needed to position itself outside the national borders. Furthermore, the society used its foreign connections to put pressure on the government in an attempt to bring Belgian psychiatry to the same level as in its neighbouring countries. The adaptation of (inter)national ideas and debates was central to its policy and resulted, within the psychiatric community, in tensions between the national and the international level. [less ▲]

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See detailVisual Spatial Math Training Tool: An iPad Application for Training Visual-Spatial Abilities in Preschoolers
Pazouki, Tahereh UL; Cornu, Véronique UL; Martin, Romain UL

Scientific Conference (2016, June 29)

In this paper, we present a full-fledged educational iOS application called VisualSpatial Math Training (VSMT), which has been developed to improve cognitive abilities in preschoolers. VSMT is a tablet ... [more ▼]

In this paper, we present a full-fledged educational iOS application called VisualSpatial Math Training (VSMT), which has been developed to improve cognitive abilities in preschoolers. VSMT is a tablet-based application that has been designed for the iPad and implemented in the Swift programming language, using the native SpriteKit framework. VSMT provides the means for working with a wide range of geometry puzzles (games) in addition to offering a solution verification engine that can verify user solutions. The main purpose of this application is to strengthen the visual-spatial abilities in young children in order to provide them and their instructors with a better foundation for understanding and teaching mathematics, respectively. Finally, we describe a series of experiments carried out using the VSMT application during special training and assessment sessions in several kindergartens in Luxembourg with over 60 pupils. [less ▲]

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