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See detailInternational law as a Negotiation tool in Banking Union; the case of the Single Resolution Fund
Asimakopoulos, Ioannis UL

in Journal of Economic Policy Reform (2018)

EU’s response to the recent Euro-crisis has involved a mixture of EU and international law, with the latter being linked to all the arrangements that may have fiscal implications for national Member ... [more ▼]

EU’s response to the recent Euro-crisis has involved a mixture of EU and international law, with the latter being linked to all the arrangements that may have fiscal implications for national Member States. The SRF embodies all the controversial characteristics of Banking Union. This article illustrates the legal implications that this political choice creates, and how the interrelation between the SRM, the SRF and the ESM, allows leading economies, including Germany, to control the resolution framework both before and after crisis. This raises questions as to the direction that European Integration is taking and its highly nationalised character. [less ▲]

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See detailProblematic smartphone use: Investigating contemporary experiences using a convergent design
Kuss, Daria J.; Harkin, Lydia; Kanjo, Eiman et al

in International Journal of Environmental Research and Public Health (2018), 15

Internet-enabled smartphones are increasingly ubiquitous in the Western world. Research suggests a number of problems can result from mobile phone overuse, including dependence, dangerous and prohibited ... [more ▼]

Internet-enabled smartphones are increasingly ubiquitous in the Western world. Research suggests a number of problems can result from mobile phone overuse, including dependence, dangerous and prohibited use. For over a decade, this has been measured by the Problematic Mobile Phone Use Questionnaire (PMPU-Q). Given the rapid developments in mobile technologies, changes of use patterns and possible problematic and addictive use, the aim of the present study was to investigate and validate an updated contemporary version of the PMPU-Q (PMPU-Q-R). A mixed methods convergent design was employed, including a psychometric survey (N = 512) alongside qualitative focus groups (N = 21), to elicit experiences and perceptions of problematic smartphone use. The results suggest the PMPU-Q-R factor structure can be updated to include smartphone dependence, dangerous driving, and antisocial smartphone use factors. Theories of problematic mobile phone use require consideration of the ubiquity and indispensability of smartphones in the present day and age, particularly regarding use whilst driving and in social interactions [less ▲]

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See detailEpigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.
Gonzalez-Vallinas, Margarita; Rodriguez-Paredes, Manuel; Albrecht, Marco UL et al

in Molecular cancer research : MCR (2018)

Most lung cancer deaths are related to metastases, which indicates the necessity of detecting and inhibiting tumor cell dissemination. Here, we aimed to identify microRNAs (miRNAs) involved in metastasis ... [more ▼]

Most lung cancer deaths are related to metastases, which indicates the necessity of detecting and inhibiting tumor cell dissemination. Here, we aimed to identify microRNAs (miRNAs) involved in metastasis of lung adenocarcinoma as prognostic biomarkers and therapeutic targets. To that end, lymph node metastasis-associated miRNAs were identified in The Cancer Genome Atlas (TCGA) lung adenocarcinoma patient cohort (sequencing data; n=449) and subsequently validated by RT-qPCR in an independent clinical cohort (n=108). Overexpression of miRNAs located on chromosome 14q32 were associated with metastasis in lung adenocarcinoma patients. Importantly, Kaplan-Meier analysis and log-rank test revealed that higher expression levels of individual 14q32 miRNAs (mir-539, mir-323b, and mir-487a) associated with worse disease-free survival of never-smoker patients. Epigenetic analysis including DNA methylation microarray data and bisulfite sequencing validation demonstrated that the induction of 14q32 cluster correlated with genomic hypomethylation of the 14q32 locus. CRISPR activation technology, applied for the first time to functionally study the increase of clustered miRNA levels in a coordinated manner, showed that simultaneous overexpression of 14q32 miRNAs promoted tumor cell migratory and invasive properties. Analysis of individual miRNAs by mimic transfection further illustrated that miR-323b-3p, miR-487a-3p, and miR-539-5p significantly contributed to the invasive phenotype through the indirect regulation of different target genes. In conclusion, overexpression of 14q32 miRNAs, associated with the respective genomic hypomethylation, promotes metastasis and correlates with poor patient prognosis in lung adenocarcinoma. IMPLICATIONS: This study points to chromosome 14q32 miRNAs as promising targets to inhibit tumor cell dissemination and to predict patient prognosis in lung adenocarcinoma. [less ▲]

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See detailSexual Dysfunction After Good-Grade Aneurysmal Subarachnoid Hemorrhage
Epprecht, Lorenz; Messerli, Michael; Samuel, Robin UL et al

in World Neurosurgery (2018)

OBJECTIVE: To assess the consequences of aneurysmal subarachnoid hemorrhage (aSAH) on sexual pleasure in patients with an otherwise favorable neurologic outcome. METHODS: Anonymous, standardized ... [more ▼]

OBJECTIVE: To assess the consequences of aneurysmal subarachnoid hemorrhage (aSAH) on sexual pleasure in patients with an otherwise favorable neurologic outcome. METHODS: Anonymous, standardized questionnaires concerning sexual function, including the International Index of Erectile Function (IIEF), Female Sexual Function Index (FSFI), and a statement on subjective change in sexual pleasure after aSAH, were completed by 33 patients treated at the Cantonal Hospital St Gallen between 2005 and 2013. All had favorable neurologic outcomes (Glasgow Outcome Scale score 4 or 5). RESULTS: Ten patients (31.3%) reported a subjective worsening of sexual pleasure after aSAH. Sexual dysfunction according to FSFI criteria affected 9 of the 19 female patients (47.4%). All 19 women had a hypoactive sexual desire disorder. Erectile dysfunction was present in 7 of the 14 male patients (50%). Patients with World Federation of Neurosurgical Societies (WFNS) grade 2 aSAH were significantly more likely to report a subjective worsening of sexual experience after hemorrhage than those with WFNS grade 1. CONCLUSIONS: This is the first known evaluation of sexual health following aSAH with otherwise favorable neurological outcomes, and confirms that sexual dysfunction is common in this population. Sexual health should be explored during follow-up with these patients [less ▲]

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See detailOutside-In region-building: The role of border integration zones in Andean regional integration
Koff, Harlan UL

in Nadalutti, Elisabetta; Kallscheuer, Otto (Eds.) Region-Making and Cross-Border Cooperation: New Evidence from Four Continents (2018)

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See detailCommunity-based monitoring for improved water governance: A case study in Holbox Island, Quintana Roo State, Mexico
Tran, Kim Chi; König, Ariane UL

in Sustainability Science: Key issues (2018)

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See detailExploring alternative futures with scenarios
Drenth, Gerard; Elahi, Shirin; König, Ariane UL

in König, Ariane (Ed.) Sustainability Science: Key issues (2018)

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See detailSystems approaches for transforming social practice: Design requirements
König, Ariane UL

in König, Ariane (Ed.) Sustainability Science: Key issues (2018)

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See detailSustainability science: Key issues
König, Ariane UL

Book published by Routledge (2018)

Detailed reference viewed: 9 (1 UL)
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See detailTesting Vision-Based Control Systems Using Learnable Evolutionary Algorithms
Ben Abdessalem (helali), Raja UL; Nejati, Shiva UL; Briand, Lionel UL et al

in Proceedings of the 40th International Conference on Software Engineering (ICSE 2018) (2018)

Vision-based control systems are key enablers of many autonomous vehicular systems, including self-driving cars. Testing such systems is complicated by complex and multidimensional input spaces. We ... [more ▼]

Vision-based control systems are key enablers of many autonomous vehicular systems, including self-driving cars. Testing such systems is complicated by complex and multidimensional input spaces. We propose an automated testing algorithm that builds on learnable evolutionary algorithms. These algorithms rely on machine learning or a combination of machine learning and Darwinian genetic operators to guide the generation of new solutions (test scenarios in our context). Our approach combines multiobjective population-based search algorithms and decision tree classification models to achieve the following goals: First, classification models guide the search-based generation of tests faster towards critical test scenarios (i.e., test scenarios leading to failures). Second, search algorithms refine classification models so that the models can accurately characterize critical regions (i.e., the regions of a test input space that are likely to contain most critical test scenarios). Our evaluation performed on an industrial automotive vision-based control system shows that: (1) Our algorithm outperforms a baseline evolutionary search algorithm and generates 78% more distinct, critical test scenarios compared to the baseline algorithm. (2) Our algorithm accurately characterizes critical regions of the system under test, thus identifying the conditions that likely to lead to system failures. [less ▲]

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See detailOptimal Channel Selection for Simultaneous RF Energy Harvesting and Data Transmission in Cognitive Radio Networks
Hooshiary, Akram; Azmi, Paeiz; Mokari, Nader et al

in Transactions on Emerging Telecommunications Technologies (2018)

In this paper, an RF-powered cognitive radio network is considered, in which the secondary users are powered by an RF energy harvester (Rectenna). Unlike most existing works, we consider a realistic ... [more ▼]

In this paper, an RF-powered cognitive radio network is considered, in which the secondary users are powered by an RF energy harvester (Rectenna). Unlike most existing works, we consider a realistic Rectenna characteristic function, and derive the actual amount of harvested energy and thus, the resulting actual energy level of the secondary users. We consider a system architecture at which simultaneous energy harvesting and data transmission for each secondary user is possible. We introduce a strategy to manage the challenge of network throughput decreasing due to lack of the secondary users’ energy, via selecting the best possible channels for energy harvesting and simultaneously by allocating the best channels for data transmission. Therefore, we implement cognition in spectrum utilization and in energy harvesting. We show that the amount of harvested energy affects the available energy of the secondary user and consequently the throughput, therefore, the channels selection to maximize energy harvesting affects the network throughput. To maximize the network throughput, the Hungarian algorithm is employed, and then, an algorithm with lower complexity based on the matching theory is proposed. Finally, we compare our proposed approach with some existing benchmarks and show its high performance in energy harvesting and system throughput. [less ▲]

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See detailA Tale of Two Referenda: The Greek Plebiscite of 1946 and the Referendum of July 2015
Paravantis, Spero UL

in European Review of History (2018)

In September 1946, after years of Civil War, Greeks were heading to the polls in order to decide the future of their country. The subject upon which they would be voting on however was not for the ... [more ▼]

In September 1946, after years of Civil War, Greeks were heading to the polls in order to decide the future of their country. The subject upon which they would be voting on however was not for the parliament and Prime Minister. Rather, the question upon which they were voting was intended to link the continuation of democracy in Greece with the monarchy in place. The question was not phrased this way. The question was if the Greeks wanted a monarchy or not; far too simple a question for its answer to be able to settle the deeply felt long-standing divisions in Greek society. In fact, the way this question was being asked at that time, was in violation of an earlier agreement, meant to end hostilities and provide a framework through which the warring parties could find a way to peace. Not surprisingly, the violation of the earlier agreement enflamed the divisions and hostilities flared again, driving Greece deeper into crisis and further delaying its recovery from occupation and Civil War. Seventy years later, a similar event played itself out in Greece. A vote took place on a question whose wording was far too complicated for the result to provide a meaningful answer to either the people of Greece or to the international community watching events unfold. In both cases, the crises highlighted the relative weakness of the state, and reduced the sense of legitimacy it held with the Greek people. This paper compares these two periods of crisis in Greece separated by 70 years; the crisis surrounding the national elections and the plebiscite on the return of the Greek monarchy in 1946 and the referendum on the terms contained in the Memorandum of Understanding (MOU) of July 2015, and the international involvement in and reaction to these referenda. The inspirations for the paper were the ways in which external forces attempted to direct the outcome of the referenda, and the similarities in the ways in which in both periods, external forces attempted to frame their definition in favor of their wider strategic objectives. [less ▲]

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See detailOne consensual depression diagnosis tool to serve many countries: a challenge! A RAND/UCLA methodology
Nabbe, P.; Le Reste, J. Y.; Guillou-Landreat, M. et al

in BMC Research Notes (2018), 11(1), 4

From a systematic literature review (SLR), it became clear that a consensually validated tool was needed by European General Practitioner (GP) researchers in order to allow multi-centred collaborative ... [more ▼]

From a systematic literature review (SLR), it became clear that a consensually validated tool was needed by European General Practitioner (GP) researchers in order to allow multi-centred collaborative research, in daily practice, throughout Europe. Which diagnostic tool for depression, validated against psychiatric examination according to the DSM, would GPs select as the best for use in clinical research, taking into account the combination of effectiveness, reliability and ergonomics? A RAND/UCLA, which combines the qualities of the Delphi process and of the nominal group, was used. GP researchers from different European countries were selected. The SLR extracted tools were validated against the DSM. The Youden index was used as an effectiveness criterion and Cronbach's alpha as a reliability criterion. Ergonomics data were extracted from the literature. Ergonomics were tested face-to-face. [less ▲]

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See detailSecure Number Theoretic Transform and Speed Record for Ring-LWE Encryption on Embedded Processors
Seo, Hwajeong; Liu, Zhe UL; Park, Taehwan et al

in The 20th Annual International Conference on Information Security and Cryptology - ICISC2017 (2017, December 30)

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See detailGenetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
McCormack, Mark; Gui, Hongsheng; Ingason, Andres et al

in Neurology (2017)

OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. METHODS ... [more ▼]

OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. METHODS: We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. RESULTS: We report an association between a rare variant in the complement factor H-related 4 (CFHR4) gene and phenytoin-induced MPE in Europeans (p = 4.5 x 10(-11); odds ratio [95% confidence interval] 7 [3.2-16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H (CFH) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients. CONCLUSIONS: The identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H-related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients. [less ▲]

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See detailRecording Belgium's Gravitational History
Van Camp, Michel; Francis, Olivier UL; Lecocq, Thomas

in EOS : Transactions, American Geophysical Union (2017)

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See detailDamnatio memoriae
Scuto, Denis UL

Article for general public (2017)

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