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See detailTranscriptional variations in the wider peritumoral tissue environment of pancreatic cancer
Kreis, Stephanie UL; Bauer, A; Hoheisel, J

in International Journal of Cancer = Journal International du Cancer (2017)

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See detailElectrophysiological correlates of performance monitoring in binge drinking: impaired error-related but preserved feedback processing
Lannoy, Severine; D'Hondt, Fabien; Dormal, Valérie et al

in Clinical Neurophysiology (2017), 128

Objective: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking ... [more ▼]

Objective: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking despite its adaptive importance in everyday life, particularly in the regulation of alcohol consumption. Capitalizing on a theoretical model of risky behaviors, the present study aimed at determining the behavioral and electrophysiological correlates of the cognitive (inhibition) and motivational (reward sensitivity) systems during performance monitoring. Methods: Event-related potentials were recorded from 20 binge drinkers and 20 nonbinge drinkers during two experimental tasks, a speeded Go/No-Go Task [investigating internal error processing by Error-Related Negativity (ERN) and error positivity (Pe)] and a Balloon Analogue Risk Task [investigating external feedback processing by Feedback-Related Negativity (FRN) and P3]. Results: While no group differences were observed at the behavioral level, electrophysiological results showed that binge drinkers, despite having intact feedback-related components, presented modified error-monitoring components (i.e. larger ERN amplitude, delayed Pe latency). Conclusions: Internal performance monitoring is impaired in binge drinkers, showing an abnormal automatic processing of response errors (ERN) and a decreased processing of their motivational significance (Pe). Significance: These results suggest that the electrophysiological correlates of inhibitory control allow identifying the specific binge drinking consumption pattern. [less ▲]

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See detailmiRNAs in ancient tissue specimens of the Tyrolean Iceman
Kreis, Stephanie UL; Keller, A; Leidinger, P et al

in Molecular Biology and Evolution (2016)

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See detailData on quantification of signaling pathways activated by KIT and PDGFRA mutants.
Bahlawane, Christelle; Schmitz, Martine UL; Letellier, Elisabeth UL et al

in Data Brief. (2016)

The present data are related to the article entitled "Insights into ligand stimulation effects on gastro-intestinal stromal tumors signaling" (C. Bahlawane, M. Schmitz, E. Letellier, K. Arumugam, N. Nicot ... [more ▼]

The present data are related to the article entitled "Insights into ligand stimulation effects on gastro-intestinal stromal tumors signaling" (C. Bahlawane, M. Schmitz, E. Letellier, K. Arumugam, N. Nicot, P.V. Nazarov, S. Haan, 2016) [1]. Constitutive and ligand-derived signaling pathways mediated by KIT and PDGFRA mutated proteins found in gastrointestinal stromal tumors (GIST) were compared. Expression of mutant proteins was induced by doxycycline in an isogenic background (Hek293 cells). Kit was identified by FACS at the cell surface and found to be quickly degraded or internalized upon SCF stimulation for both Kit Wild type and Kit mutant counterparts. Investigation of the main activated pathways in GIST unraveled a new feature specific for oncogenic KIT mutants, namely their ability to be further activated by Kit ligand, the stem cell factor (scf). We were also able to identify the MAPK pathway as the most prominent target for a common inhibition of PDGFRA and KIT oncogenic signaling. Western blotting and micro-array analysis were applied to analyze the capacities of the mutant to induce an effective STATs response. Among all Kit mutants, only Kit Ex11 deletion mutant was able to elicit an effective STATs response whereas all PDGFRA were able to do so. [less ▲]

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See detailHow women’s entrepreneurship builds on collaborative entrepreneurship
Constantinidis, Christina UL

in ISBE (Ed.) ISBE Conference 2016 Proceedings (2016, October 27)

This communication is part of a larger research project that aims to develop and test a model about the collaboration practices of female entrepreneurs, through identifying antecedents and consequences ... [more ▼]

This communication is part of a larger research project that aims to develop and test a model about the collaboration practices of female entrepreneurs, through identifying antecedents and consequences for entrepreneurial success. The objective of our communication is to explore collaborative entrepreneurship, an emerging topic in the literature, from the perspective of female entrepreneurs in Luxembourg. We share here the first insights brought by our exploratory study on this relatively underinvestigated topic, in particular in the women’s entrepreneurship field. Through the analysis of an in-depth longitudinal case study with two women entrepreneurs who created and developed a business collaboration, completed by a set of qualitative interviews with other women entrepreneurs working in collaboration, we are able to propose a first understanding of this phenomenon and to establish the bases for a theoretical model. [less ▲]

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See detailNumerical simulation and Identification of the Failure Criterion for Structural Silicone
Staudt, Yves UL; Odenbreit, Christoph UL; Schneider, Jens

Speeches/Talks (2016)

In civil engineering, silicone sealants are widely used in structural sealant glazing applications as an adhesively bonded connection between the glass panels and the building substructure. The current ... [more ▼]

In civil engineering, silicone sealants are widely used in structural sealant glazing applications as an adhesively bonded connection between the glass panels and the building substructure. The current design concept does not take into account the actual stress state and the actual failure mechanism. Therefore, no information about the exact failure probability can be given. Alternative approaches, such as the Finite Element Analysis, also have major disadvantages due to the presence of singularities. Therefore, a method from Finite Fracture Mechanics, calibrated with experimental investigations on bulk material, is applied on silicone sealants, focusing on the shear failure mechanism. The procedure is validated using small scale tests such as simple shear and torsion tests. [less ▲]

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See detailMultiCoSteel – Structural Behaviour of Heavy Composite Columns with Multiple Encased Steel Profiles for High Rise Buildings
Chrzanowski, Maciej UL; Odenbreit, Christoph UL

Speeches/Talks (2016)

The PhD resesarch project“MultiCoSteel” is foussed on the investigation of the beam theory for composite columns with multiple encased steel profiles to find the correct internal stress distributions and ... [more ▼]

The PhD resesarch project“MultiCoSteel” is foussed on the investigation of the beam theory for composite columns with multiple encased steel profiles to find the correct internal stress distributions and stiffnesses. The suitability of the Euler-Bernoulli Theory will be investigated as well as the truss theory and the Vierendeel theory. A complex interaction between steel and concrete materials and lack of knowledge regarding composite behaviour opens opportunities to develop, improve and optimise the system and the design method. Within this research project both aspects will be handled with the objectives; 1) to develop the new, easy-applicable and efficient type of shear connector for an application in composite columns with multiple-encased steel profiles and 2) to prove the design hypothesis of Vierendeel mechanism behaviour. The project is running with close collaboration of industrial partner - ArcelorMittal and it was successfully qualified to the FNR AFR-PPP PhD Grant. [less ▲]

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See detailApplication of the extended discrete element method (XDEM) in the melting of a single particle
Baniasadi, Mehdi UL; Baniasadi, Maryam UL; Peters, Bernhard UL

in Baniasadi, Mehdi (Ed.) Application of the extended discrete element method (XDEM) in the melting of a single particle (2016, July 19)

In this contribution, a new method referred to as Extended Discrete Element Method (XDEM) is usedto model melting of a single particle in the fluid media. The XDEM as a Lagrangian-Eulerian framework is ... [more ▼]

In this contribution, a new method referred to as Extended Discrete Element Method (XDEM) is usedto model melting of a single particle in the fluid media. The XDEM as a Lagrangian-Eulerian framework is the extension of Discrete Element Method (DEM) by considering thermodynamic state such as temperature distribution and is able to link with Computational Fluid Dynamics (CFD) for fluid phase. In order to provide more accurate results, multiscale method was used. The model is validated by comparing predicted results with existing experimental data for melting of a single ice particle in a water bath. In addition, the model has the capability to be extended to the packed bed of particles with different size and properties to produce different liquid phases. [less ▲]

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See detailWomen and growth in the French context: Exploratory findings
Constantinidis, Christina UL; Chasserio, Stéphanie; Masurel, Sabine et al

in GWO (Ed.) GWO2016 Book of Abstracts (2016, July 01)

High-growth companies intensely contribute to our economies and constitute a particular area of interest for entrepreneurship scholars. Growth is also one of the major indicators of entrepreneurial ... [more ▼]

High-growth companies intensely contribute to our economies and constitute a particular area of interest for entrepreneurship scholars. Growth is also one of the major indicators of entrepreneurial success in the literature. Female entrepreneurs’ growth intentions and behaviors therefore constitute central questions for researchers in the field. Our contention is to develop a typology of female-managed businesses, differentiating between various growth patterns. We do not consider women entrepreneurs as a homogeneous group, rather taking into account the diversity of existing realities. In order to develop this typology, we rely on an existing French database, Women Equity for Growth, that has been measuring the performances of women-led businesses for five years. [less ▲]

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See detailFinal Report for the INTER Mobility BiFaLy
Aleksic, Gabrijela UL

Report (2016)

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See detailCFD-XDEM FOR PREDICTING MULTIPHASE FLOW BEHAVIOR THROUGH POROUS MEDIA
Baniasadi, Maryam UL; Peters, Bernhard UL

Scientific Conference (2016, June 05)

An accurate description of fluid flow through porous media is very important to predict, design and optimize many industrial phenomena principally in condition where experimental studies are difficult to ... [more ▼]

An accurate description of fluid flow through porous media is very important to predict, design and optimize many industrial phenomena principally in condition where experimental studies are difficult to perform. In these kind of problems numerical simulations can help to gain a better process understanding. During last decades many numerical approaches mainly Finite Volume Method (FVM) were applied to model different multiphase flows containing gas, liquid and solid phases. The solid phase may treat by continuous or discrete frameworks. In the former method which is based on Eulerian framework the solid phase is considered as a continuous phase like other fluid phases while in the second method which is based on Lagrangian framework, the solid phase is considered as separate particles. In this study, the flow behavior of several incompressible isotherm phases through solid particles was modelled. The model describes the motion of fluid flows such as gas and liquid phases using continuum approach by applying Computational Fluid Dynamics (CFD) as a numerical method and the solid particles by Lagrangian framework using so-called eXtended Discrete Element Method (XDEM). XDEM is a numerical simulation framework based on classical Discrete Element Methods (DEM) extended by consideration of thermophysical states. A combination of the two numerical methods was performed through momentum and mass exchange between fluid and solid phases which is called combined continuum discrete approach. The solid phase is considered as packed solid particles. The model results demonstrate enormous effect of solid particles on deviation of fluid phases while passing through particles by testing different drag force models. This model was applied to the dripping zone of blast furnace where the liquid phases of liquid iron and slag flow downward through coke particles and gas phase ascends upwards through the shaft which is classified as a counter-current multiphase packed bed reactor. The main goal of this project is to provide a solver which is able to treat several fluid phases through porous media using combined Eulerian-Lagrangian framework by exchanging data between this two approaches. [less ▲]

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See detailL’entrepreneuriat collaboratif sous l’angle du genre : Le cas des femmes entrepreneures luxembourgeoises
Constantinidis, Christina UL

Scientific Conference (2016, May 19)

The aim of this communication is to explore an emergent topic in the entrepreneurship literature, collaborative entrepreneurship, with the perspective of female entrepreneurs in Luxembourg. We share the ... [more ▼]

The aim of this communication is to explore an emergent topic in the entrepreneurship literature, collaborative entrepreneurship, with the perspective of female entrepreneurs in Luxembourg. We share the first insights from an exploratory study on this relatively unexplored topic, in particular in the women's entrepreneurship field. The in-depth case study analysis of two female entrepreneurs who created and developed a business collaboration, complemented by qualitative interviews with female entrepreneurs working in collaboration, enable to propose first elements of understanding of this phenomenon and to establish the bases of a theoretical model. [less ▲]

Detailed reference viewed: 11 (2 UL)
See detailThe influence of language and culture on the dynamics of mixed couples
Aleksic, Gabrijela UL

Presentation (2016, May 17)

Detailed reference viewed: 2 (1 UL)
See detailÖkonomische Inszenierungen
Bloch, Natalie UL

Speeches/Talks (2016)

Detailed reference viewed: 12 (0 UL)
See detailFamily literacy programme for Portuguese preschool children in Luxembourg
Aleksic, Gabrijela UL

Presentation (2016, May 02)

Detailed reference viewed: 1 (0 UL)
See detailGender impacts on business succession: Men, women, and the family company
Nelson, Dylan; Constantinidis, Christina UL; Bell, Deborah et al

Poster (2016, March 31)

Building on a previous study of the family business succession literature, showing that gender is considered conceptually only in the case of women, we aim to uncover the sons’ gender stories.

Detailed reference viewed: 7 (1 UL)