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See detailInflammatory signaling in liver cells: Cross-regulation of the IL-6/JAK/STAT3 pathway and microRNAs
Servais, Florence UL

Doctoral thesis (2017)

Interleukin-6 (IL-6) plays important roles in the regulation of liver functions and promotes the development of hepatocellular carcinoma (HCC), the most common primary liver cancer. Whereas protein ... [more ▼]

Interleukin-6 (IL-6) plays important roles in the regulation of liver functions and promotes the development of hepatocellular carcinoma (HCC), the most common primary liver cancer. Whereas protein-encoding genes are well-studied, the contribution of IL-6-regulated microRNAs (miRNAs) to its effects is largely unexplored. Similarly, little is known about miRNAs regulating key molecules of the IL-6/JAK/STAT3 signaling pathway. In the main part of this thesis, cell-based high-throughput screenings systems were developed, allowing the identification of miRNAs interfering with the IL-6/JAK/STAT3 signaling. Out of 538 miRNA mimics, this dual screening approach followed by various validation steps (luciferase-3’UTR-reporter assays, western blot and flow cytometry analyses) allowed us to identify twelve miRNAs targeting STAT3, JAK1, SOCS3, IL6R and/or gp130, ten of them had not yet been reported as regulators of this pathway before. In the second part of this work, microarray analyses revealed that primary hepatocytes are considerably more responsive to IL-6 stimulation regarding changes in their miRNomes than liver-derived cell lines. Despite their weaker response, one of the top regulated miRNA found in the primary hepatocytes, miR-146b-5p, could also be induced by IL-6-type cytokines (IL-6 and Oncostatin M) in cell lines. Its functional role(s) in hepatocytes are currently investigated. A larger, comparative study included additionally Interferon gamma and IL-27, cytokines with a STAT1-dominated response, and supplementary cell lines originating not only from the liver but also from other tissues. While all cytokines had profound effects on the mRNA transcriptomes, only very small to moderate changes were observed at the miRNome level, suggesting that the regulation mediated by cytokines mainly happens through the modulation of protein-coding genes rather than by fine-tuning via miRNAs. Additionally, we analyzed expression of a broad panel of cytokines in sera of 125 patients with liver diseases (steatosis, non-alcoholic steatohepatitis, HCC) by bead-based multiplex immunoassays. We observed that, for example, serum HGF, IL-6 and IL-8 levels increased in relation with the severeness of liver pathology while PDGF-BB and RANTES decreased. When investigating the impact of the patatin-like phospholipase domain-containing protein 3 variant I148M (PNPLA3 I148M), known to be a risk factor for the development of liver diseases, on the serum levels of cytokines, no significant differences could be observed between the different genotypes. In this PhD thesis, we identified and characterized miRNAs relevant for the IL-6/JAK/STAT3 signaling pathway, including miR-146b-5p as an IL-6-inducible miRNA. Others like miR-194-5p, miR-4473 and miR-548k were demonstrated to be negative regulators of this pathway and may be of potential therapeutic significance. In addition, we showed that, while miRNAs can modulate this pathway, IL-6 seems to rather regulate the mRNA transcriptome than the miRNome. [less ▲]

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See detailSpecification and Analysis of Resource Utilization Policies for Human-Intensive Systems (Extended Abstract)
Shin, Seung Yeob UL

in Proceedings of the BPM Demo Track and BPM Dissertation Award co-located with 15th International Conference on Business Process Management (BPM 2017) (2017, September 10)

Societal processes, such as those used in healthcare, typically depend on the effective utilization of resources, both human and non-human. Sound policies for the management of these resources are crucial ... [more ▼]

Societal processes, such as those used in healthcare, typically depend on the effective utilization of resources, both human and non-human. Sound policies for the management of these resources are crucial in assuring that these processes achieve their goals. But complex utilization policies may govern the use of such resources, increasing the difficulty of accurately incorporating resource considerations into complex processes. This dissertation presents an approach to the specification, allocation, and analysis of the management of such resources. [less ▲]

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See detail3D Printing: The Next 5 years by Claude Wolf – Into the Future engineered by the Zs
Wolf, Claude UL

E-print/Working paper (2017)

3D Printing: The Next 5 years by Claude Wolf – Into the Future engineered by the Zs The future of 3D Printing or Additive Manufacturing [AM] will be driven by the next generation of engineers who are just ... [more ▼]

3D Printing: The Next 5 years by Claude Wolf – Into the Future engineered by the Zs The future of 3D Printing or Additive Manufacturing [AM] will be driven by the next generation of engineers who are just about to qualify, the Z generation (1994-2010). Do we, educators, know this Z generation? Do we know what motivates them? The Z generation is a generation of digital natives interacting with PCs, iPads, smartphones and the internet since birth, a pragmatic and short term orientated generation. Our prejudice brands them as unprepared and unmotivated, with their 10 second attention spans, but in reality, they have already proven they are creative, determined and hardworking as well as team oriented, when they are given the opportunity. They have understood that 3D printing offers them this opportunity. [less ▲]

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See detailAvatar Sex Moderates Aggression in Violent Video Games, But Only for Women
Melzer, André UL; Schmidt, Alexander F.

Poster (2017, September 07)

Three studies tested findings reported by Yang, Huesmann, and Bushman (2014) that playing a male avatar in a violent video game leads to greater aggression than playing a female avatar in the same game ... [more ▼]

Three studies tested findings reported by Yang, Huesmann, and Bushman (2014) that playing a male avatar in a violent video game leads to greater aggression than playing a female avatar in the same game. The male avatar effect was confirmed in Study 1 (N=79) for post-game aggression: compared to playing a female character, participants who had played the male fighter in a violent mixed martials arts game chose more Hot Sauce for another participant who allegedly disliked spicy food. In contrast to Yang et al. (2014), however, the male avatar effect was qualified by participant sex, indicating that the effect was more strongly pronounced and only significant for female participants. A similar interaction effect was observed in Study 2 (N=76) and Study 3 (N=70) for in-game aggression: only female participants playing a male avatar showed a greater hit ratio in a mixed martials arts game (Study 2) or a greater number of attacks in a brawler game (Study 3) than their colleagues who played a female avatar. At this stage, the reason for this cross-gender effect is unclear. Given that games allow for behavior (i.e., aggression) independent of socially shared gender norms, we may speculate that for women, male avatars may provide the opportunity to “step out” of prevailing social norms regarding non-aggressive female behavior and adopt the role of the (hyper-)aggressive male. However, this hypothesis needs to be tested in future studies. All three studies additionally tested the mediating effect of male gender stereotype activation that was hypothesized by Yang et al. (2014). In addition to priming violent behavior, and in line with the General Aggression Model, the authors had speculated that playing the male avatar automatically activated male gender stereotypes (i.e., aggressive thoughts and behavior) which then caused aggressive behavior. In order to address this activation hypothesis, we designed an indirect cognitive measure of gender role identity using the Positive-Negative Sex-Role Inventory (PN-SRI: Berger & Krahé, 2013). After participants played the violent game, positive and negative aspects of masculinity and femininity were presented as word fragments in a five-minute response window in Study 1 and 2. Fragment completion rates served as indicators of cognitive activation of male stereotypes. In Study 3, participants used the intact PN-SRI gender attributes to rate the avatar after playing the game. However, both direct and indirect measures failed to corroborate the stereotype activation hypothesis in the present studies: word fragments related to male stereotypes were not completed more often than fragments related to female stereotypes (Study 1 and 2). Also, neither in-game aggression nor success in the game was associated with how masculine participants perceived their fighter (Study 3). At the present stage, thus, the mechanisms underlying the gender effect that participants respond differently when playing a male or female avatar in a violent video game remain unclear. [less ▲]

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See detailTommaso Padoa-Schioppa [biography]
Chiocchetti, Paolo UL

E-print/Working paper (2017)

Tommaso Padoa-Schioppa (1940-2010) was an Italian banker, economist, and politician. He was one of the "architects of the euro" and helped to push forward the financial, monetary, and economic integration ... [more ▼]

Tommaso Padoa-Schioppa (1940-2010) was an Italian banker, economist, and politician. He was one of the "architects of the euro" and helped to push forward the financial, monetary, and economic integration of Europe. [less ▲]

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See detailScattering theory without injectivity radius assumptions and spectral stability for the Ricci flow
Güneysu, Batu; Thalmaier, Anton UL

E-print/Working paper (2017)

We prove a completely new integral criterion for the existence and completeness of the wave operators W_{\pm}(-\Delta_h,-\Delta_g, I_{g,h}) corresponding to the (unique self-adjoint realizations of) the ... [more ▼]

We prove a completely new integral criterion for the existence and completeness of the wave operators W_{\pm}(-\Delta_h,-\Delta_g, I_{g,h}) corresponding to the (unique self-adjoint realizations of) the Laplace-Beltrami operators -\Delta_j, j=g,h, that are induced by two quasi-isometric complete Riemannian metrics g and h on an open manifold M. In particular, this result provides a criterion for the absolutely continuous spectra of -\Delta_g and -\Delta_h to coincide. Our proof relies on estimates that are obtained using a probabilistic Bismut type formula for the gradient of a heat semigroup. Unlike all previous results, our integral criterion only requires some lower control on the Ricci curvatures and some upper control on the heat kernels, but no control at all on the injectivity radii. As a consequence, we obtain a stability result for the absolutely continuous spectrum under a Ricci flow. [less ▲]

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See detailExposure to Sexualized Pictures Primes Occupational Stereotypes
Melzer, André UL; Ramsperger, Stephan

Scientific Conference (2017, September 05)

Gender stereotypes in advertisements, magazines, or videogames often appear in the form of sexualized portrayals of women characterized by inappropriately foregrounding female sexuality. Women are shown ... [more ▼]

Gender stereotypes in advertisements, magazines, or videogames often appear in the form of sexualized portrayals of women characterized by inappropriately foregrounding female sexuality. Women are shown with highly revealing clothing and engaging in seductive acts. Sexualization may serve as a motivator to adopt congruent gender-related stereotypes in the viewers and, thus, influence beliefs about women in the real world, including negative effects on self-efficacy of women (Behm-Morawitz & Mastro, 2009). In two studies, sexualization had similar adverse effects on participants’ spontaneous judgments of occupational stereotypes and job classification. In a field study (Study 1, N=128), sexualized female game characters were spontaneously associated with jobs of lower prestige (e.g., hairdresser). In contrast, non-sexualized portrayals were linked to jobs of higher status (i.e., physician, educator). This detrimental effect of sexualized portrayal on occupational status was replicated for depictions of male and female fashion models in an online survey (Study 2, N=459). Moreover, this effect was partially mediated by ratings of lower perceived competence for sexualized portrayals of both men and women. The findings of the present studies extend the multifaceted negative effects of sexualization on stereotyping by showing that the resulting spontaneous competence judgments may have detrimental job-related consequences. [less ▲]

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See detailOpening remarks: From Tablet to Tablet – workshop Jewish Studies & Digital Humanities, Hamburg, 4-6 September 2017
Zaagsma, Gerben UL

Presentation (2017, September 05)

This is the written version of opening remarks I gave at From Tablet to Tablet, a workshop on Jewish Studies and Digital Humanities supported by the Rothschild Foundation Hanadiv Europe in co-operation ... [more ▼]

This is the written version of opening remarks I gave at From Tablet to Tablet, a workshop on Jewish Studies and Digital Humanities supported by the Rothschild Foundation Hanadiv Europe in co-operation with the Institute for the History of the German Jews that took place in Hamburg between 4-6 September 2017. [less ▲]

Peer Reviewed
See detailPartis politiques et religions aux Amériques et en Europe
Poirier, Philippe UL

in Portier, Philippe; Dieckhoff, Alain (Eds.) L'Enjeu mondial. Religion & politique (2017)

Dieu n'est pas mort. Il fait de la politique. Partout dans le monde, le religieux est de retour. Son ascendant se ressent à l'intérieur des États comme sur la scène internationale et ce, jusqu’en Occident ... [more ▼]

Dieu n'est pas mort. Il fait de la politique. Partout dans le monde, le religieux est de retour. Son ascendant se ressent à l'intérieur des États comme sur la scène internationale et ce, jusqu’en Occident, où il semblait promis à une irrémédiable occultation. Le constat, enthousiasmant pour les uns, dérangeant pour les autres, est sans appel : la modernité n’a pas induit la disparition sociale, ni surtout politique, du religieux. Trois phénomènes majeurs le traduisent : la polarisation des sociétés partagées entre effacement et réaffirmation des croyances, la politisation renouvelée des religions, la spiritualisation des politiques. Pour autant, il ne s’agit en aucun cas d’un retour aux temps anciens, quand toute vie sociale était configurée par le religieux. Fruit d’une coopération entre le Centre de recherches internationales de Sciences Po et le Groupe sociétés, religions, laïcités de l’École pratique des hautes études, cet ouvrage révèle toute la complexité d’un espace contemporain en tension perpétuelle entre sécularisation et réenchantement du monde. [less ▲]

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See detailCan health indicators and psychosocial characteristics predict attrition in youth with overweight and obesity seeking ambulatory treatment? Data from a retrospective longitudinal study in a paediatric clinic in Luxembourg.
Pit-Ten Cate, Ineke UL; Samouda, Hanen; Schierloh, Ulrike et al

in BMJ Open (2017), 7(9),

ABSTRACT Objectives: The current study aimed to identify factors that could predict attrition in youth starting ambulatory treatment to control or lose weight. Design: retrospective longitudinal study ... [more ▼]

ABSTRACT Objectives: The current study aimed to identify factors that could predict attrition in youth starting ambulatory treatment to control or lose weight. Design: retrospective longitudinal study Setting: paediatric clinic: ambulatory treatment program Patients and measures: A youth sample (N=191; 89 boys; age 7-17 years) completed measures of demographic characteristics, health and psychosocial traits before starting an ambulatory weight management program. Anthropometric and biological markers related to obesity were also obtained. Test of mean differences and regression analyses were used to investigate the relationship between these variables and attrition after one year. Results: Chi-square and t-test results showed both psychosocial and health indicators differentiated between participants who continued attending the treatment program and those that dropped out. More specifically, youth that dropped out of treatment were significantly older, had higher BMI-Z scores, higher levels of insulin, triglycerides and HOMA-IR, reported poorer health and more conduct problems, and were more dissatisfied with themselves and their bodies before starting treatment. Results of regression analyses revealed that weight status (anthropometric and biological markers), age and body dissatisfaction predict attrition (overall prediction success 73%; prediction success for continued attendance 90/91%; prediction success for dropout 42/44%). Conclusion: Attrition, but especially the continued attendance in treatment, can be successfully predicted by age, weight status and body dissatisfaction. For patients who present with one or more risk factors, careful consideration is needed to decide which (combination of) in- or outpatient program may facilitate prolonged engagement of the patient and hence may be most effective in establishing weight loss. [less ▲]

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See detailIntroduction to Detection of Non-Technical Losses using Data Analytics
Glauner, Patrick UL; Meira, Jorge Augusto UL; State, Radu UL et al

Scientific Conference (2017, September)

Electricity losses are a frequently appearing problem in power grids. Non-technical losses (NTL) appear during distribution and include, but are not limited to, the following causes: Meter tampering in ... [more ▼]

Electricity losses are a frequently appearing problem in power grids. Non-technical losses (NTL) appear during distribution and include, but are not limited to, the following causes: Meter tampering in order to record lower consumptions, bypassing meters by rigging lines from the power source, arranged false meter readings by bribing meter readers, faulty or broken meters, un-metered supply, technical and human errors in meter readings, data processing and billing. NTLs are also reported to range up to 40% of the total electricity distributed in countries such as Brazil, India, Malaysia or Lebanon. This is an introductory level course to discuss how to predict if a customer causes a NTL. In the last years, employing data analytics methods such as data mining and machine learning have evolved as the primary direction to solve this problem. This course will compare and contrast different approaches reported in the literature. Practical case studies on real data sets will be included. Therefore, attendees will not only understand, but rather experience the challenges of NTL detection and learn how these challenges could be solved in the coming years. [less ▲]

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See detailDie steuerrechtlichen Herausforderungen der digitalen Wirtschaft - Was passiert in Europa?
Sinnig, Julia UL

in Taeger, Juergen (Ed.) Tagungsband Herbstakademie 2017: Recht 4.0 - Innovationen aus den rechtswissenschaftlichen Laboren (2017, September)

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See detailSprachbiographien und ihre Bedeutung in multilingualen Kontexten. Eine Fallstudie aus Luxemburg
Kirsch, Claudine UL; Cicero Catanese, Giovanni

in Zeitschrift für Grundschulforschung, Bildung im Elementar- und Primarbereich (2017), 10(2), 35-48

Sprachbiographien dokumentieren und kontextualisieren Spracherfahrungen, helfen dem Lernenden, die eigene Sprachentwicklung und das Sprachverhalten zu verstehen, und ermöglichen Pädagogen, passende ... [more ▼]

Sprachbiographien dokumentieren und kontextualisieren Spracherfahrungen, helfen dem Lernenden, die eigene Sprachentwicklung und das Sprachverhalten zu verstehen, und ermöglichen Pädagogen, passende Sprachangebote zu machen. Das Fallbeispiel eines mehrsprachigen Kindes in Luxemburg gibt einen Einblick in und Anstoß für sprachbiographische Forschung und Praxis. Die Ergebnisse der longitudinalen Studie illustrieren, erstens, Daniels offene Haltung gegenüber Sprachen und Spracherfahrungen, seinen dynamischen Sprachgebrauch und seine sich entwickelnde Fähigkeit zur Reflexion und, zweitens, den Einfluss der Eltern und Schule. [less ▲]

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See detailComparing Broad-Phase Interaction Detection Algorithms for Multiphysics DEM Applications
Rousset, Alban UL; Mainassara Chekaraou, Abdoul Wahid UL; Liao, Yu-Chung UL et al

Scientific Conference (2017, September)

Collision detection is an ongoing source of research and optimization in many fields including video-games and numerical simulations [6, 7, 8]. The goal of collision detection is to report a geometric ... [more ▼]

Collision detection is an ongoing source of research and optimization in many fields including video-games and numerical simulations [6, 7, 8]. The goal of collision detection is to report a geometric contact when it is about to occur or has actually occurred. Unfortunately, detailed and exact collision detection for large amounts of objects represent an immense amount of computations, naivly n 2 operation with n being the number of objects [9]. To avoid and reduce these expensive computations, the collision detection is decomposed in two phases as it shown on Figure 1: the Broad-Phase and the Narrow-Phase. In this paper, we focus on Broad-Phase algorithm in a large dynamic three-dimensional environment. We studied two kinds of Broad-Phase algorithms: spatial partitioning and spatial sorting. Spatial partitioning techniques op- erate by dividing space into a number of regions that can be quickly tested against each object. Two types of spatial partitioning will be considered: grids and trees. The grid-based algorithms consist of a spatial partitioning processing by dividing space into regions and testing if objects overlap the same region of space. And this reduces the number of pairwise to test. The tree-based algorithms use a tree structure where each node spans a particular space area. This reduces the pairwise checking cost because only tree leaves are checked. The spatial sorting based algorithm consists of a sorted spatial ordering of objects. Axis-Aligned Bounding Boxes (AABBs) are projected onto x, y and z axes and put into sorted lists. By sorting projection onto axes, two objects collide if and only if they collide on the three axes. This axis sorting reduces the number of pairwise to tested by reducing the number of tests to perform to only pairs which collide on at least one axis. For this study, ten different Broad-Phase collision detection algorithms or framework have been considered. The Bullet [6], CGAL [10, 11] frameworks have been used. Concerning the implemented algorithms most of them come from papers or given implementation [less ▲]

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See detailKomplexes Problemlösen und Intelligenz
Greiff, Samuel UL

Scientific Conference (2017, September)

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See detailDie Trainierbarkeit von komplexem Problemlösen im Rahmen eines Trainings für Experimentieren.
Stebner, Ferdinand; Kunze, Thiemo UL; Kemper, Christoph UL et al

Scientific Conference (2017, September)

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